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中华神经创伤外科电子杂志 ›› 2026, Vol. 12 ›› Issue (03) : 180 -184. doi: 10.3877/cma.j.issn.2095-9141.2026.03.006

综述

生酮饮食对创伤性脑损伤神经保护作用的研究进展
沈嵩民1, 崔昌萌2, 许彪1, 徐向楠1, 吴璐莎3,()   
  1. 1272067 山东济宁,济宁医学院临床医学院(附属医院)
    2272029 山东济宁,济宁医学院附属医院神经外科
    3315000 浙江宁波,宁波大学附属妇女儿童医院
  • 收稿日期:2024-12-07 出版日期:2026-06-15
  • 通信作者: 吴璐莎

Research progress on the neuroprotective effects of the ketogenic diet in traumatic brain injury

Songmin Shen1, Changmeng Cui2, Biao Xu1, Xiangnan Xu1, Lusha Wu3,()   

  1. 1Clinical Medical College of Jining Medical University (Affiliated Hospital), Jining 272067, China
    2Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining 272029, China
    3Ningbo Women and Children’s Hospital, Ningbo 315000, China
  • Received:2024-12-07 Published:2026-06-15
  • Corresponding author: Lusha Wu
  • Supported by:
    National Natural Science Foundation of China(82471414); Zhejiang Provincial Medical and Health Science and Technology Program-Appropriate Technology Cultivation and Promotion Project(2021ZH005)
引用本文:

沈嵩民, 崔昌萌, 许彪, 徐向楠, 吴璐莎. 生酮饮食对创伤性脑损伤神经保护作用的研究进展[J/OL]. 中华神经创伤外科电子杂志, 2026, 12(03): 180-184.

Songmin Shen, Changmeng Cui, Biao Xu, Xiangnan Xu, Lusha Wu. Research progress on the neuroprotective effects of the ketogenic diet in traumatic brain injury[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2026, 12(03): 180-184.

创伤性脑损伤(TBI)是致死率和致残率较高的疾病类型,目前尚缺乏能够有效预防其长期神经功能障碍的治疗方法。近年动物研究表明,生酮饮食(KD)可通过调节能量代谢、改善线粒体功能及减轻神经炎症等机制,发挥神经元保护作用,并促进神经功能恢复,为TBI治疗提供了新的策略方向。本文就KD的生理作用、代谢机制及在TBI治疗中的神经保护作用的可能机制及临床应用展开综述,以期为KD在TBI中的进一步基础研究及临床转化应用提供理论依据。

Traumatic brain injury (TBI) is a disease type with high mortality and disability rates, and effective treatments to prevent long-term neurological dysfunction remain lacking. Recent animal studies have shown that the ketogenic diet (KD) can exert neuroprotective effects and promote neurological recovery by regulating energy metabolism, enhancing mitochondrial function, and alleviating neuroinflammation, thereby providing a novel strategic direction for the treatment of TBI. This review explores the physiological and metabolic effects of KD, its potential neuroprotective mechanisms in TBI, and its clinical applications, aiming to provide a theoretical basis for further basic research and clinical translation of KD in TBI.

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