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中华神经创伤外科电子杂志 ›› 2026, Vol. 12 ›› Issue (03) : 129 -135. doi: 10.3877/cma.j.issn.2095-9141.2026.03.001

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脑机接口联合神经调控在创伤性脑损伤继发脑功能障碍康复中的应用现状及展望
薛文1, 段虎斌2,()   
  1. 1033000 山西吕梁,吕梁市第一人民医院神经外科
    2030000 太原,山西医科大学第一医院神经外科
  • 收稿日期:2026-05-26 出版日期:2026-06-15
  • 通信作者: 段虎斌

Application status and prospects of brain-computer interface combined with neural regulation in the rehabilitation of secondary brain dysfunction after traumatic brain injury

Wen Xue1, Hubin Duan2,()   

  1. 1Department of Neurosurgry, Lvliang First People’s Hospital, Lvliang 033000, China
    2Department of Neurosurgry, the First Hospital of Shanxi Medical University, Taiyuan 030000, China
  • Received:2026-05-26 Published:2026-06-15
  • Corresponding author: Hubin Duan
  • Supported by:
    National Natural Science Foundation of China(30600637); Research Special Project of National Clinical Key Specialty Construction Program(2023011, 24090522); Key Research Project for Introducing High-level Scientific and Technological Talents in Lu’an City(2023RC08, 2024RC19); Research Project of Health Commission of Shanxi Province-Project on Integrating Medicine, Engineering and Medicine(2025YGYL010); Shanxi Talent Program of Shanxi Provincial Science and Technology Department(16073)
引用本文:

薛文, 段虎斌. 脑机接口联合神经调控在创伤性脑损伤继发脑功能障碍康复中的应用现状及展望[J/OL]. 中华神经创伤外科电子杂志, 2026, 12(03): 129-135.

Wen Xue, Hubin Duan. Application status and prospects of brain-computer interface combined with neural regulation in the rehabilitation of secondary brain dysfunction after traumatic brain injury[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2026, 12(03): 129-135.

创伤性脑损伤(TBI)后常继发认知、运动、情绪及意识等神经功能障碍,具有致残率高、康复周期长、传统康复疗效有限等特点,是神经外科与康复医学领域亟待突破的难题。随着人工智能与神经工程技术的快速迭代,脑机接口(BCI)可实现脑功能信号的实时解码与闭环交互,神经调控技术能够精准靶向调节异常神经环路兴奋性,二者的联合应用打破了传统康复被动训练的局限,构建了"神经信号监测-精准调控-主动功能重塑"的新型康复体系。本文结合近年国内外相关研究进展,系统阐述BCI与神经调控技术协同作用的神经机制,总结其联合应用在TBI后意识障碍、运动功能缺损、认知及情绪障碍康复中的临床价值,分析当前技术融合、临床落地、标准化体系建设中存在的瓶颈问题,并对未来智能化、精准化、个体化神经康复的发展方向进行展望,旨在为TBI后脑功能障碍的精准诊疗及康复提供新思路与理论参考。

Traumatic brain injury (TBI) is often secondary to brain dysfunctions such as cognitive, motor, emotional and consciousness disorders, which are characterized by high disability rate, long rehabilitation cycle and limited efficacy of traditional rehabilitation, and have become an urgent problem to be solved in the fields of neurosurgery and rehabilitation medicine. With the rapid iteration of artificial intelligence and neuroengineering technology, brain-computer interface (BCI) can realize real-time decoding and closed-loop interaction of brain functional signals, and neuromodulation technology can accurately target and regulate the excitability of abnormal neural circuits. The combined application of the two breaks the limitations of passive training in traditional rehabilitation and constructs a new rehabilitation system of "neural signal monitoring-precise regulation-active functional remodeling". Based on the recent domestic and foreign research progress, this paper systematically expounds the neural mechanism of the synergistic effect of BCI and neuromodulation technology, summarizes the clinical application value of their combination in the rehabilitation of post-traumatic consciousness disturbance, motor function defect, cognitive and emotional disorders, analyzes the current bottlenecks in technology integration, clinical implementation and standardized system construction, and prospects for the future development direction of intelligent, precise and individualized neural rehabilitation, aiming to provide new ideas and theoretical references for precise diagnosis, treatment, and rehabilitation of functional disorders after TBI.

表1 临床常用的神经调控技术
Tab.1 Commonly used clinical neuromodulation techniques
技术类型 侵入性 技术原理 主要不良反应 TBI康复适用场景
重复经颅磁刺激 无创 利用交变磁场无创穿透颅骨,调控大脑皮层神经元兴奋性 局部头皮疼痛、头晕、短暂头痛,高频刺激偶发皮层兴奋性异常,无严重器质性损伤风险 轻中度TBI后运动功能障碍、认知减退、情绪焦虑抑郁,适配长期常态化康复干预,临床应用最广泛
经颅直流电刺激 无创 通过微弱恒定直流电作用于大脑皮层,极性调控神经元兴奋性 电极接触部位皮肤发红、轻微灼热感,不良反应轻微、耐受性良好 TBI后注意力缺陷、记忆力下降、轻度运动痉挛,可联合BCI认知训练同步干预
脑深部电刺激 有创 借助立体定向手术植入深部脑电极,输出高频电脉冲调控异常神经核团与环路活动 手术出血、感染、电极移位,长期刺激可能引发脑区节律紊乱,存在一定手术风险 重度难治性TBI后意识障碍、持续性肢体痉挛瘫痪,经常规无创干预无效的重症患者
聚焦超声 微创/无创 聚焦超声能量作用于深部脑区,通过热效应与机械效应调控神经活动,可逆开放血脑屏障并修复异常神经环路 局部脑组织短暂水肿、温热刺激,长期安全性尚未完全验证 目前以基础研究、动物实验为主,暂未应用于常规TBI临床康复,具备潜在精准调控价值
经颅光生物调节 无创 通过特定波长近红外光穿透颅骨,激活脑细胞线粒体代谢,改善脑区能量供给,调节神经兴奋性,修复受损脑功能 偶见轻微头痛或头皮发热 阿尔茨海默病、轻度认知障碍、抑郁症、焦虑症、TBI后应激障碍、脑损伤、卒中康复及神经发育障碍等
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