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中华神经创伤外科电子杂志 ›› 2020, Vol. 06 ›› Issue (04) : 244 -247. doi: 10.3877/cma.j.issn.2095-9141.2020.04.012

所属专题: 文献

综述

慢性创伤性脑病研究进展
路旭1, 杨俊丽1, 王娜1, 周沁晔2, 符锋3,()   
  1. 1. 300162 天津,武警特色医学中心神经外科
    2. 300162 天津,武警后勤学院学兵二大队十队
    3. 300162 天津,武警特色医学中心疼痛科
  • 收稿日期:2020-02-12 出版日期:2020-08-15
  • 通信作者: 符锋
  • 基金资助:
    国家自然科学基金(81971782); 天津市自然科学基金(19JCYBJ27900); 武警部队军事理论研究计划课题(WJJY20JL0473)

Advance of the research on chronic traumatic encephalopathy

Xu Lu1, Junli Yang1, Na Wang1, Qinye Zhou2, Feng Fu3,()   

  1. 1. Department of Neurosurgery, Armed Police Special Medical Center, Tianjin 300162, China
    2. Armed Police Logistics College Second Brigade Team 10 Team, Tianjin 300162, China
    3. Department of Pain, Armed Police Special Medical Center, Tianjin 300162, China
  • Received:2020-02-12 Published:2020-08-15
  • Corresponding author: Feng Fu
  • About author:
    Corresponding author: Fu Feng, Email:
引用本文:

路旭, 杨俊丽, 王娜, 周沁晔, 符锋. 慢性创伤性脑病研究进展[J]. 中华神经创伤外科电子杂志, 2020, 06(04): 244-247.

Xu Lu, Junli Yang, Na Wang, Qinye Zhou, Feng Fu. Advance of the research on chronic traumatic encephalopathy[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(04): 244-247.

慢性创伤性脑病(CTE)是一种以脑内磷酸化tau蛋白异常积聚为特征的神经病理学疾病。目前公认的神经病理学标准仍只是初步的,一方面因为该标准基于数量有限的选定样本,另一方面目前很少有研究将CTE的病理与其他神经退行性疾病(如阿尔兹海默病)进行比较。此外,CTE被广泛认为是反复头部受击的结果,但一次中度或重度的颅脑创伤(TBI)也可诱发CTE。基于不同的观点,本文结合国内外文献就CTE特点、研究历史以及TBI与CTE的相关性作一综述。

Chronic traumatic encephalopathy (CTE) is a neuropathological disease characterized by abnormal accumulation of phosphorylated tau protein in the brain. The currently recognized neuropathological standards are still preliminary, On one hand, they are based on a limited number of selected samples, and on the other hand, there are few studies that compare the pathology of CTE with other neurodegenerative diseases such as Alzheimer’s disease. In addition, CTE is widely considered to be the result of repeated head attacks, but a moderate or severe traumatic brain injury (TBI) can also induce CTE. Based on different viewpoints, this article summarizes the characteristics of CTE, research history, and the correlation between TBI and CTE based on domestic and foreign literature.

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