儿童创伤性脑损伤的研究进展

doi:10.3877/cma.j.issn.2095-9141.2022.02.012

创伤性脑损伤（TBI）是儿科较常见的急危重症，也是儿童残疾和死亡的重要原因，且有逐年增加的趋势。但儿童TBI的流行病学调查发现重度TBI的发病率下降，轻度TBI明显增多。由于TBI后存在长期慢性创伤性脑病的风险，目前儿童脑震荡的病理生理学、结局以及TBI程度的检测日益引起关注。去骨瓣减压术在儿童TBI中的作用仍未阐明。本文就近年来国内外关于儿童TBI的研究进展作一综述。

关键词: 创伤性脑损伤, 生物标志物, 脑震荡后综合征, 外伤性癫痫, 慢性创伤性脑病, 儿童

Traumatic brain injury (TBI) is a common acute and critical illness in pediatrics, and it is also an important cause of child disability and death, and has an increasing trend year by year. However, the epidemiological investigation of children’s TBI shown that the incidence of severe TBI decreased, while the incidence of mild TBI increased significantly. Due to the long-term risk of chronic traumatic encephalopathy, the pathophysiology and outcome of concussion in children, as well as the detection of the degree of craniocerebral injury, have attracted increasing attention. The role of decompressive craniectomy in children with TBI remains to be elucidated. This article reviews the research progress on TBI in children at home and abroad in recent years.

Key words: Traumatic brain injury, Biomarkers, Postconcussion syndrome, Posttraumatic epilepsy, Chronic traumatic encephalopathy, Children

[1]	Kochar A, Borland ML, Phillips N, et al. Association of clinically important traumatic brain injury and Glasgow Coma Scale scores in children with head injury[J]. Emerg Med J, 2020, 37(3): 127-134.
[2]	Smith EB, Lee JK, Vavilala MS, et al. Pediatric traumatic brain injury and associated topics: an overview of abusive head trauma, nonaccidental trauma, and sports concussions[J]. Anesthesiol Clin, 2019, 37(1): 119-134.
[3]	McKinlay A, Albicini M, Than M. Preinjury characteristics of children with mild traumatic brain injury: Is "other injury" an appropriate comparison group?[J]. J Clin Exp Neuropsychol, 2018, 40(3): 285-291.
[4]	路旭,杨俊丽,王娜,等.慢性创伤性脑病研究进展[J].中华神经创伤外科电子杂志, 2020, 6(4): 244-247.
[5]	Almeida AA, Lorincz MT, Hashikawa AN. Recent advances in pediatric concussion and mild traumatic brain injury[J]. Pediatr Clin North Am, 2018, 65(6): 1151-1166.
[6]	Putukian M, Riegler K, Amalfe S, et al. Preinjury and postinjury factors that predict sports-related concussion and clinical recovery time[J]. Clin J Sport Med, 2021, 31(1): 15-22.
[7]	McNally KA, Patrick KE, LaFleur JE, et al. Brief cognitive behavioral intervention for children and adolescents with persistent post-concussive symptoms: a pilot study[J]. Child Neuropsychol, 2018, 24(3): 396-412.
[8]	Minney MJ, Roberts RM, Mathias JL, et al. Service and support needs following pediatric brain injury: perspectives of children with mild traumatic brain injury and their parents[J]. Brain Inj, 2019, 33(2): 168-182.
[9]	Bennett TD, Marsh R, Maertens JA, et al. Decision-making about intracranial pressure monitor placement in children with traumatic brain injury[J]. Pediatr Crit Care Med, 2019, 20(7): 645-651.
[10]	Babl FE, Oakley E, Dalziel SR, et al. Accuracy of clinician practice compared with three head injury decision rules in children: a prospective cohort study[J]. Ann Emerg Med, 2018, 71(6): 703-710.
[11]	Mayer AR, Kaushal M, Dodd AB, et al. Advanced biomarkers of pediatric mild traumatic brain injury: progress and perils[J]. Neurosci Biobehav Rev, 2018, 94: 149-165.
[12]	Oris C, Pereira B, Durif J, et al. The biomarker S100B and mild traumatic brain injury: a meta-analysis[J]. Pediatrics, 2018, 141(6): e20180037.
[13]	Lugones M, Parkin G, Bjelosevic S, et al. Blood biomarkers in paediatric mild traumatic brain injury: a systematic review[J]. Neurosci Biobehav Rev, 2018, 87: 206-217.
[14]	Langness S, Ward E, Halbach J, et al. Plasma D-dimer safely reduces unnecessary CT scans obtained in the evaluation of pediatric head trauma[J]. J Pediatr Surg, 2018, 53(4): 752-757.
[15]	Chamard E, Lichtenstein JD. A systematic review of neuroimaging findings in children and adolescents with sports-related concussion[J]. Brain Inj, 2018, 32(7): 816-831.
[16]	Wu T, Merkley TL, Wilde EA, et al. A preliminary report of cerebral white matter microstructural changes associated with adolescent sports concussion acutely and subacutely using diffusion tensor imaging[J]. Brain Imaging Behav, 2018, 12(4): 962-973.
[17]	Toth A, Kornyei B, Kovacs N, et al. Both hemorrhagic and non-hemorrhagic traumatic MRI lesions are associated with the microstructural damage of the normal appearing white matter[J]. Behav Brain Res, 2018, 340: 106-116.
[18]	Hanks R, Millis S, Scott S, et al. The relation between cognitive dysfunction and diffusion tensor imaging parameters in traumatic brain injury[J]. Brain Inj, 2019, 33(3): 355-363.
[19]	de Souza NL, Parker R, Gonzalez CS, et al. Effect of age at time of injury on long-term changes in intrinsic functional connectivity in traumatic brain injury[J]. Brain Inj, 2020, 34(12): 1646-1654.
[20]	Stephens JA, Salorio CF, Barber AD, et al. Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury[J]. Dev Neurorehabil, 2018, 21(7): 423-430.
[21]	Churchill NW, Hutchison MG, Graham SJ, et al. Connectomic markers of symptom severity in sport-related concussion: whole-brain analysis of resting-state fMRI[J]. Neuroimage Clin, 2018, 18: 518-526.
[22]	Young AMH, Guilfoyle MR, Donnelly J, et al. Multimodality neuromonitoring in severe pediatric traumatic brain injury[J]. Pediatr Res, 2018, 83(1-1): 41-49.
[23]	McHugh DC, Fiore SM, Strong N, et al. Bifrontal biparietal cruciate decompressive craniectomy in pediatric traumatic brain injury[J]. Pediatr Neurosurg, 2019, 54(1): 6-11.
[24]	Manfiotto M, Beccaria K, Rolland A, et al. Decompressive craniectomy in children with severe traumatic brain injury: a multicenter retrospective study and literature review[J]. World Neurosurg, 2019, 129: e56-e62.
[25]	Ardissino M, Tang A, Muttoni E, et al. Decompressive craniectomy in paediatric traumatic brain injury: a systematic review of current evidence[J]. Childs Nerv Syst, 2019, 35(2): 209-216.
[26]	Meinert E, Bell MJ, Buttram S, et al. Initiating nutritional support before 72 hours is associated with favorable outcome after severe traumatic brain injury in children: a secondary analysis of a randomized, controlled trial of therapeutic hypothermia[J]. Pediatr Crit Care Med, 2018, 19(4): 345-352.
[27]	Recla M, Galbiati S, Pastore V, et al. Children sustaining a severe acquired brain lesion before age 3 years: a follow-up study at 1 year from insult[J]. Brain Inj, 2019, 33(2): 160-167.
[28]	Beretta E, Molteni E, Galbiati S, et al. Five-year motor functional outcome in children with acquired brain injury. Yet to the end of the story?[J]. Dev Neurorehabil, 2018, 21(7): 449-456.
[29]	Hwang SY, Ong JW, Ng ZM, et al. Long-term outcomes in children with moderate to severe traumatic brain injury: a single-centre retrospective study[J]. Brain Inj, 2019, 33(11): 1420-1424.
[30]	Keenan HT, Presson AP, Clark AE, et al. Longitudinal developmental outcomes after traumatic brain injury in young children: are infants more vulnerable than toddlers?[J]. J Neurotrauma, 2019, 36(2): 282-292.
[31]	Clasby B, Hughes N, Catroppa C, et al. Community-based interventions for adolescents following traumatic brain injury: a systematic review[J]. NeuroRehabilitation, 2018, 42(3): 345-363.
[32]	Keret A, Shweiki M, Bennett-Back O, et al. The clinical characteristics of posttraumatic epilepsy following moderate-to-severe traumatic brain injury in children[J]. Seizure, 2018, 58: 29-34.
[33]	Ciccia AH, Beekman L, Ditmars E. A clinically focused systematic review of social communication in pediatric TBI[J]. NeuroRehabilitation, 2018, 42(3): 331-344.
[34]	Todis B, McCart M, Glang A. Hospital to school transition following traumatic brain injury: a qualitative longitudinal study[J]. NeuroRehabilitation, 2018, 42(3): 269-276.
[35]	Lambregts SAM, Smetsers JEM, Verhoeven IMAJ, et al. Cognitive function and participation in children and youth with mild traumatic brain injury two years after injury[J]. Brain Inj, 2018, 32(2): 230-241.

[1]	张璇, 马宇童, 苗玉倩, 张云, 吴士文, 党晓楚, 陈颖颖, 钟兆明, 王雪娟, 胡淼, 孙岩峰, 马秀珠, 吕发勤, 寇海燕. 超声对Duchenne肌营养不良儿童膈肌功能的评价[J]. 中华医学超声杂志（电子版）, 2023, 20(10): 1068-1073.
[2]	张宝富, 俞劲, 叶菁菁, 俞建根, 马晓辉, 刘喜旺. 先天性原发隔异位型肺静脉异位引流的超声心动图诊断[J]. 中华医学超声杂志（电子版）, 2023, 20(10): 1074-1080.
[3]	韩丹, 王婷, 肖欢, 朱丽容, 陈镜宇, 唐毅. 超声造影与增强CT对儿童肝脏良恶性病变诊断价值的对比分析[J]. 中华医学超声杂志（电子版）, 2023, 20(09): 939-944.
[4]	刘婷婷, 林妍冰, 汪珊, 陈幕荣, 唐子鉴, 代东伶, 夏焙. 超声衰减参数成像评价儿童代谢相关脂肪性肝病的价值[J]. 中华医学超声杂志（电子版）, 2023, 20(08): 787-794.
[5]	周钰菡, 肖欢, 唐毅, 杨春江, 周娟, 朱丽容, 徐娟, 牟芳婷. 超声对儿童髋关节暂时性滑膜炎的诊断价值[J]. 中华医学超声杂志（电子版）, 2023, 20(08): 795-800.
[6]	米洁, 陈晨, 李佳玲, 裴海娜, 张恒博, 李飞, 李东杰. 儿童头面部外伤特点分析[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 511-515.
[7]	李越洲, 张孔玺, 李小红, 商中华. 基于生物信息学分析胃癌中PUM的预后意义[J]. 中华普通外科学文献(电子版), 2023, 17(06): 426-432.
[8]	王蕾, 王少华, 牛海珍, 尹腾飞. 儿童腹股沟疝围手术期风险预警干预[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 768-772.
[9]	李芳, 许瑞, 李洋洋, 石秀全. 循证医学理念在儿童腹股沟疝患者中的应用[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 782-786.
[10]	吕垒, 冯啸, 何凯明, 曾凯宁, 杨卿, 吕海金, 易慧敏, 易述红, 杨扬, 傅斌生. 改良金氏评分在儿童肝豆状核变性急性肝衰竭肝移植手术时机评估中价值并文献复习[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 661-668.
[11]	陈安, 冯娟, 杨振宇, 杜锡林, 柏强善, 阴继凯, 臧莉, 鲁建国. 基于生物信息学分析CCN4在肝细胞癌中表达及其临床意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 702-707.
[12]	卓少宏, 林秀玲, 周翠梅, 熊卫莲, 马兴灶. CD64指数、SAA/CRP、PCT联合检测在小儿消化道感染性疾病鉴别诊断中的应用[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 505-509.
[13]	吴蓉菊, 向平超. COPD频繁急性加重表型与炎性因子相关性研究[J]. 中华临床医师杂志(电子版), 2023, 17(9): 939-947.
[14]	刘笑笑, 张小杉, 刘群, 马岚, 段莎莎, 施依璐, 张敏洁, 王雅晳. 中国学龄前儿童先天性心脏病流行病学研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(9): 1021-1024.
[15]	李静, 张玲玲, 邢伟. 兴趣诱导理念用于小儿手术麻醉诱导前的价值及其对家属满意度的影响[J]. 中华临床医师杂志(电子版), 2023, 17(07): 812-817.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Research progress of childhood traumatic brain injury

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Research progress of childhood traumatic brain injury