切换至 "中华医学电子期刊资源库"

中华神经创伤外科电子杂志 ›› 2016, Vol. 02 ›› Issue (05) : 302 -304. doi: 10.3877/cma.j.issn.2095-9141.2016.05.010

所属专题: 文献

专题笔谈

创伤性颅脑损伤继发凝血功能异常的发生机制
李田飞1, 李军1, 魏梁锋1, 王守森1,()   
  1. 1. 350025 福州,南京军区福州总医院神经外科
  • 收稿日期:2016-04-23 出版日期:2016-10-15
  • 通信作者: 王守森
  • 基金资助:
    全军后勤科技重大项目(AHJ14J001)

Research progress of mechanism about the secondary coagulation dysfunction following the traumatic brain injury

Tianfei Li1, Jun Li1, Liangfeng Wei1, Shousen Wang1,()   

  1. 1. Department of Neurosurgery, Fuzong Clinical College, Bengbu Medical College, Fuzhou 350025, China
  • Received:2016-04-23 Published:2016-10-15
  • Corresponding author: Shousen Wang
  • About author:
    Corresponding author: Wang Shousen, Email:
引用本文:

李田飞, 李军, 魏梁锋, 王守森. 创伤性颅脑损伤继发凝血功能异常的发生机制[J/OL]. 中华神经创伤外科电子杂志, 2016, 02(05): 302-304.

Tianfei Li, Jun Li, Liangfeng Wei, Shousen Wang. Research progress of mechanism about the secondary coagulation dysfunction following the traumatic brain injury[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(05): 302-304.

创伤性颅脑损伤(TBI)可继发凝血功能异常,其发生机制包括:血小板功能异常、uPA/tPA的异常激活、神经细胞源性微颗粒的释放、蛋白C系统激活、组织因子释放、凝血因子Ⅶ活性改变等。本文就近年来的研究进行简要综述,阐述在TBI的不同时期继发凝血功能异常的可能机制。

Coagulant abnormality can occur secondary to traumatic brain injury (TBI) . The mechanism includes platelet dysfunction, abnormal activation of UPA/TPA, brain-derived microparticulars (BDMP) , activation of protein C system, release of tissue factors (TF) , change of blood coagulation factor Ⅶ activity, etc. In this review, recently researches were briefly reviewed to illuminate the possible mechanisms of this secondary coagulant abnormality in the different phases of TBI.

[1]
de Oliveira Manoel AL, Neto AC, Veigas PV, et al. Traumatic brain injury associated coagulopathy[J]. Neurocrit Care, 2015, 22(1): 34-44.
[2]
Epstein DS, Mitra B, O'Reilly G, et al. Acute traumatic coagulopathy in the setting of isolated traumatic brain injury: A systematic review and meta-analysis[J]. Injury, 2014, 45(5): 819-824.
[3]
Lustenberger T, Talving P, Kobayashi L, et al. Time course of coagulopathy in isolated severe traumatic brain injury[J]. Injury, 2010, 41(9): 924-928.
[4]
Alexiou GA, Lianos G, Fotakopoulos G, et al. Admission glucose and coagulopathy occurrence in patients with traumatic brain injury[J]. Brain Inj, 2014, 28(4): 438-441.
[5]
Gerlach R, Krause M, Seifert V, et al. Hemostatic and hemorrhagic problems in neurosurgical patients[J]. Acta Neurochir (Wien), 2009, 151(8): 873-900.
[6]
Joseph B, Aziz H, Zangbar B, et al. Acquired coagulopathy of traumatic brain injury defined by routine laboratory tests: which laboratory values matter[J]. Trauma Acute Care Surg, 2014, 76(1): 121-125.
[7]
Davis PK, Musunuru H, Walsh M, et al. Platelet dysfunction is an early marker for traumatic brainInjury-induced coagulopathy[J]. Neurocrit Care, 2013, 18(2): 201-208.
[8]
Sillesen M. Coagulation changes following traumatic brain injury and shock[J]. Dan Med J, 2014, 61(12): B4974.
[9]
Sillesen M, Johansson PI, Rasmussen LS, et al. Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage[J]. Trauma Acute Care Surg, 2013, 74(5): 1252-1259.
[10]
Sillesen M, Rasmussen LS, Jin G, et al. Assessment of coagulopathy, endothelial injury, and inflammation after traumatic brain injury and hemorrhage in a porcine model[J]. Trauma Acute Care Surg, 2014, 76(1): 12-19.
[11]
Docagne F, Parcq J, Lijnen R, et al. Understanding the functions of endougenous and exogenous tissue-type plasminogen activator during stroke[J]. Stroke, 2015, 46(1): 314-320.
[12]
Chapin JC, Hajjar KA. Fibrinolysis and the control of blood coagulation[J]. Blood Rev, 2015, 29(1): 17-24.
[13]
Hijazi N, Abu Fanne R, Abramovitch R, et al. Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice[J]. Blood, 2015, 125(16): 2558-2567.
[14]
田野.神经细胞来源Microparticles在颅脑创伤相关凝血功能障碍发生中的机制研究[D].天津医科大学, 2014.
[15]
Tian Y, Salsbery B, Wang M, et al. Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury[J]. Blood, 2015, 125(13): 2151-2159.
[16]
Esmon CT. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation[J]. Crit Care Med, 2001, 29(7 Suppl): S48-51.
[17]
Somajo S, Koshiar RL, Norstrm E, et al. Protein S and Facter V in regulation of coagulatio on platelet microparticles by activated peoctin C[J]. Thromb Res, 2014, 134(1): 144-152.
[18]
Cohen MJ, Brohi K, Ganter MT, et al. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway[J]. Trauma, 2007, 63(6): 1254-1261.
[19]
Cimmino G, Ciccarelli G, Golino P. Role of tissue factor in the coagulation network[J]. Semin Thromb Hemost, 2015, 41(7): 708-717.
[20]
Gerlach R, Krause M, Seifert V, et al. Hemostatic and hemorrhagic problems in neurosurgical patients[J]. Acta Neurochir (Wien), 2009, 151(8): 873-900.
[21]
吴雪海,江观玉,干建新,等.闭合性颅脑损伤后组织因子、组织因子途径抑制物的动态变化及其意义[J].中华创伤杂志, 2002, 18(8): 489-491.
[22]
秦国强,漆松涛,黄卫民,等.组织因子及组织因子途径抑制物-1在重型颅脑外伤早期的变化及意义[J].广东医学, 2015, 36(13): 2076-2078.
[23]
Hedner U. Recombinant activated factor VII: 30 years of research and innovation[J]. Blood Rev, 2015, 29(Suppl 1): S4-8.
[24]
骆实,许小兵,郭燕舞,等.血浆辅助治疗脑外伤后凝血功能障碍疗效分析[J].中华神经医学杂志, 2013, 12(4): 398-400.
[25]
栗超跃,裴兵兵,吴惺,等.单纯性颅脑创伤患者凝血因子Ⅶ活性与凝血功能障碍和进展性颅内出血性损伤的相关性分析[J].中华医学杂志, 2014, 94(9): 688-691.
[26]
Wu X, Du Z, Yu J, et al. Activity of factor VII in patients with isolated blunt traumatic brain injury: association with coagulopathy and progressive hemorrhagic injury[J]. J Trauma Acute Care Surg, 2014, 76(1): 114-120.
[27]
Yuan Q, Wu X, Du ZY, et al. Low-dose recombinant factor VIIa for reversing coagulopathy in patients with isolated traumatic brain injury[J]. J Crit Care, 2015, 30(1): 116-120.
[1] 赵淑樱, 张聃. 腹腔镜胃癌外科治疗进展与发展趋势[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 459-462.
[2] 何羽. 腔镜微创手术治疗分化型甲状腺癌的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 456-458.
[3] 赵家劲, 谢肖俊. 复发性腹壁切口疝的研究进展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(01): 21-24.
[4] 刘璐璐, 何羽. 慢性阻塞性肺病患者睡眠障碍的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 836-839.
[5] 白正林, 高明, 孟增东. 肩关节置换术后假体周围感染的研究进展[J/OL]. 中华肩肘外科电子杂志, 2024, 12(03): 271-276.
[6] 王守森, 傅世龙, 鲜亮, 林珑. 深入理解控制性减压技术对创伤性颅脑损伤术中脑膨出的预防机制与效果[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 257-262.
[7] 毛进鹏, 陶治鹤, 刘琦, 王勇, 周明安, 陈劲松, 田少斌. 保守治疗大量创伤性硬膜外血肿的体会(附10例报告)[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(03): 164-168.
[8] 辛强, 朱文豪, 何川, 李文臣, 陈勃, 王海峰. 神经胶质细胞来源的外泌体miRNAs对创伤性颅脑损伤后神经炎症的影响[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(03): 169-173.
[9] 鹿海龙, 朱玉辐, 贺雪凤, 蔡廷江, 王栋, 朱圣玲, 张恩刚, 王策. 创伤性颅脑损伤二次手术的危险因素分析及预警模型构建[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(02): 97-101.
[10] 苗楠, 宗子钰. 脑出血后继发性脑损伤与线粒体相关机制的研究进展[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(02): 107-111.
[11] 刘彪, 巍山, 关永胜. 基于Rotterdam CT评分及凝血功能指标的创伤性颅脑损伤预后预测模型的构建与验证[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(01): 22-27.
[12] 胡志恒, 任洪波, 宋志远, 张运刚, 韩晓正. 血清sTIM-3及其配体Gal-9、CEACAM-1与创伤性颅脑损伤患者脑损伤程度及预后的关系[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 201-207.
[13] 武继敏, 袁春雨, 王鲁佳, 陈伟霞, 李晓东, 马丽虹. 重复经颅磁刺激治疗脑卒中后中枢性疼痛的研究进展[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(03): 182-186.
[14] 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845.
[15] 陈娟, 邓静敏. 胸部子宫内膜异位综合征的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(01): 96-100.
阅读次数
全文


摘要