脑出血后继发性脑损伤与线粒体相关机制的研究进展

doi:10.3877/cma.j.issn.2095-9141.2024.02.008

脑出血是一种高致残率、高致死率以及低治愈率的脑血管疾病，脑出血造成的脑损伤会对患者的脑组织造成非常严重的伤害，其中一个主要的病理机制是患者的线粒体结构以及功能稳态平衡遭受破坏，脑出血后继发脑损伤患者的线粒体结构以及功能的变化对患者神经元的保护具有重要意义。近年来随着对线粒体通透性转换孔、线粒体自噬以及线粒体氧化应激等线粒体稳态失衡研究的深入，其与脑出血后继发性脑损伤之间的相关机制也愈加明确。本文对脑出血后继发性脑损伤与线粒体相关机制进行归纳及综述，以期为脑出血后继发性脑损伤临床应用提供新的思路和方法。

关键词: 脑出血, 继发性脑损伤, 线粒体, 机制, 研究进展

Intracerebral hemorrhage is a cerebrovascular disease with high disability rate, high mortality rate and low cure rate. The brain injury caused by intracerebral hemorrhage will cause very serious damage to the patient's brain tissue, one of the main pathological mechanisms is the destruction of the patient's mitochondrial structure and functional homeostasis, the changes of mitochondrial structure and function in patients with secondary brain injury after intracerebral hemorrhage are of great significance for the protection of neurons. In recent years, with the deepening of the research on mitochondrial homeostasis imbalance such as mitochondrial permeability transition pore, mitochondrial autophagy and mitochondrial oxidative stress, the related mechanism between it and secondary brain injury after intracerebral hemorrhage has become more and more clear. This paper summarizes and summarizes the related mechanisms between secondary brain injury and mitochondria after intracerebral hemorrhage, in order to provide new ideas and methods for the clinical application of secondary brain injury after intracerebral hemorrhage.

Key words: Intracerebral hemorrhage, Secondary brain injury, Mitochondrion, Mechanism, Research progress

[20]	Klimova N, Long A, Kristian T. Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice[J]. J Neurosci Res, 2019, 97(8): 975-990. DOI: 10.1002/jnr.24397.
[21]	Jiang Q, Wang L, Si X, et al. Current progress on the mechanisms of hyperhomocysteinemia-induced vascular injury and use of natural polyphenol compounds[J]. Eur J Pharmacol, 2021, 905: 174168. DOI: 10.1016/j.ejphar.2021.174168.
[22]	Zhang B, Gao Y, Li Q, et al. Effects of brain-derived mitochondria on the function of neuron and vascular endothelial cell after traumatic brain injury[J]. World Neurosurg, 2020, 138: e1-e9. DOI: 10.1016/j.wneu.2019.11.172.
[23]	Wang Y, Liu Y, Li Y, et al. Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function[J]. Acta Histochem, 2019, 121(1): 56-63. DOI: 10.1016/j.acthis.2018.10.014.
[24]	Yu X, Jia L, Yu W, et al. Dephosphorylation by calcineurin regulates translocation of dynamin-related protein 1 to mitochondria in hepatic ischemia reperfusion induced hippocampus injury in young mice[J]. Brain Res, 2019, 1711: 68-76. DOI: 10.1016/j.brainres.2019.01.018.
[25]	Zhao J, Qu D, Xi Z, et al. Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF[J]. Transl Res, 2021, 235: 102-114. DOI: 10.1016/j.trsl.2021.03.017.
[26]	Singh-Mallah G, Nair S, Sandberg M, et al. The role of mitochondrial and endoplasmic reticulum reactive oxygen species production in models of perinatal brain injury[J]. Antioxid Redox Signal, 2019, 31(9): 643-663. DOI: 10.1089/ars.2019.7779.
[27]	Diao X, Zhou Z, Xiang W, et al. Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction[J]. Brain Res, 2020, 1727: 146514. DOI: 10.1016/j.brainres.2019.146514.
[28]	Zhao Y, Yan F, Yin J, et al. Synergistic interaction between zinc and reactive oxygen species amplifies ischemic brain injury in rats[J]. Stroke, 2018, 49(9): 2200-2210. DOI: 10.1161/strokeaha.118.021179.
[29]	Wang B, Han S. Modified exosomes reduce apoptosis and ameliorate neural deficits induced by traumatic brain injury[J]. ASAIO J, 2019, 65(3): 285-292. DOI: 10.1097/mat.0000000000000810.
[30]	杨梅桂,郑凯,宋质银.线粒体-内质网相互作用机制、功能及其与相关疾病的关系研究进展[J].新乡医学院学报, 2020, 37(10): 996-1001. DOI: 10.7683/xxyxyxb.2020.10.021.
[31]	Nebie O, Carvalho K, Barro L, et al. Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment[J]. Brain, 2021, 144(10): 3142-3158. DOI: 10.1093/brain/awab205.
[32]	Chen Y, Meng J, Xu Q, et al. Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI[J]. Brain Res, 2019, 1710: 163-172. DOI: 10.1016/j.brainres.2019.01.005.
[33]	Yang Y, Zhao X, Wang R. Research progress on the formation mechanism and detection technology of bread flavor[J]. J Food Sci, 2022, 87(9): 3724-3736. DOI: 10.1111/1750-3841.16254.
[1]	Zhu H, Wang Z, Yu J, et al. Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage[J]. Prog Neurobiol, 2019, 178: 101610. DOI: 10.1016/j.pneurobio.2019.03.003.
[2]	Wu X, Cui W, Guo W, et al. Acrolein aggravates secondary brain injury after intracerebral hemorrhage through Drp1-mediated mitochondrial oxidative damage in mice[J]. Neurosci Bull, 2020, 36(10): 1158-1170. DOI: 10.1007/s12264-020-00505-7.
[3]	Xu W, Li T, Gao L, et al. Sodium benzoate attenuates secondary brain injury by inhibiting neuronal apoptosis and reducing mitochondria-mediated oxidative stress in a rat model of intracerebral hemorrhage: Possible involvement of DJ-1/Akt/IKK/NFκB pathway[J]. Front Mol Neurosci, 2019, 12: 105. DOI: 10.3389/fnmol.2019.00105.
[4]	Zheng J, Shi L, Liang F, et al. Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats[J]. Front Neurosci, 2018, 12: 414. DOI: 10.3389/fnins.2018.00414.
[5]	陈斌,成宜军,陈正鸿,等.脑出血后神经细胞死亡机制的研究进展[J].中国脑血管病杂志, 2018, 15(3): 153-156. DOI: 10.3969/j.issn.1672-5921.2018.03.009.
[6]	吴倩,王丽醌,伍国锋.脑出血后激活PPAR-γ对继发性脑损伤的治疗价值研究进展[J].重庆医科大学学报, 2021, 46(5): 529-532. DOI: 10.13406/j.cnki.cyxb.002538.
[7]	Zhang Y, Rui T, Luo C, et al. Mdivi-1 alleviates brain damage and synaptic dysfunction after intracerebral hemorrhage in mice[J]. Exp Brain Res, 2021, 239(5): 1581-1593. DOI: 10.1007/s00221-021-06089-6.
[8]	Diao X, Zhou Z, Xiang W, et al. Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction[J]. Brain Res, 2020, 1727: 146514. DOI: 10.1016/j.brainres.2019.146514.
[9]	Ma H, Wang X, Zhang W, et al. Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis[J]. Oxid Med Cell Longev, 2020, 2020: 9067610. DOI: 10.1155/2020/9067610.
[10]	Anqi X, Ruiqi C, Yanming R, et al. Neuroprotective potential of GDF11 in experimental intracerebral hemorrhage in elderly rats[J]. J Clin Neurosci, 2019, 63: 182-188. DOI: 10.1016/j.jocn.2019.02.016.
[11]	Wang S, Hou J. Research progress on the regulatory mechanism of hepatic inflammation-induced carcinogenesis[J]. Chin J Cancer Bioth, 2020, 27(1): 1-8. DOI: 10.3872/j.issn.1007-385X.2020.01.001.
[12]	Niu J, Hu R. Role of flunarizine hydrochloride in secondary brain injury following intracerebral hemorrhage in rats[J]. Int J Immunopathol Pharmacol, 2017, 30(4): 413-419. DOI: 10.1177/0394632017742224.
[13]	Deng D, Wang W, Li XL, et al. Research progress on mechanisms of Chinese materia medica in treatment of hypertension[J]. Chin Trad Herbal Drugs, 2017, 48(21): 4565-4570. DOI: 10.7501/j.issn.0253-2670.2017.21.032.
[14]	Kang X, Zuo Z, Hong W, et al. Progress of research on exosomes in the protection against ischemic brain injury[J]. Front Neurosci, 2019, 13: 1149. DOI: 10.3389/fnins.2019.01149.
[15]	吴丹,漆仲文,张伟,等.脑缺血/再灌注损伤后线粒体结构与功能稳态失衡机制的研究进展[J].中国医药导报, 2021, 18(31): 42-45, 66.
[16]	张润芳,叶青青,冯硕,等.线粒体自噬保护缺血性脑损伤的作用及相关中药研究现状[J].中国临床药理学杂志, 2021, 37(22): 3176-3179. DOI: 10.13699/j.cnki.1001-6821.2021.22.039.
[17]	郭士佳,俞春江,陈立杰.线粒体功能障碍与脑缺血的研究进展[J].中西医结合心脑血管病杂志, 2019, 17(24): 3964-3966. DOI: 10.12102/j.issn.1672-1349.2019.24.026.
[18]	Wang Z, Tang M. Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells[J]. J Appl Toxicol, 2021, 41(5): 683-700. DOI: 10.1002/jat.4121.
[19]	Angelova PR, Esteras N, Abramov AY. Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: finding ways for prevention[J]. Med Res Rev, 2021, 41(2): 770-784. DOI: 10.1002/med.21712.

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