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中华神经创伤外科电子杂志 ›› 2024, Vol. 10 ›› Issue (03) : 169 -173. doi: 10.3877/cma.j.issn.2095-9141.2024.03.008

综述

神经胶质细胞来源的外泌体miRNAs对创伤性颅脑损伤后神经炎症的影响
辛强1, 朱文豪1, 何川1, 李文臣1, 陈勃1, 王海峰1,†()   
  1. 1. 130021　长春，吉林大学第一医院神经创伤外科
  • 收稿日期:2023-11-16 出版日期:2024-06-15
  • 通信作者: 王海峰

Effect of glial cell-derived exosomal miRNAs on neuroinflammation after traumatic brain injury

Qiang Xin1, Wenhao Zhu1, Chuan He1, Wenchen Li1, Bo Chen1, Haifeng Wang1,†()   

  1. 1. Department of Neurotrauma Surgery, First Hospital of Jilin University, Changchun 130021, China
  • Received:2023-11-16 Published:2024-06-15
  • Corresponding author: Haifeng Wang
  • Supported by:
    National Natural Science Foundation of China(81871555); Fund of Jilin Provincial Science and Technology Department(20200603002SF); Fund of Jilin Provincial Finance Department(JLSCZD2019-006, JLSWSRCZX2021-028, 2018SCZWSZX-006)
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辛强, 朱文豪, 何川, 李文臣, 陈勃, 王海峰. 神经胶质细胞来源的外泌体miRNAs对创伤性颅脑损伤后神经炎症的影响[J]. 中华神经创伤外科电子杂志, 2024, 10(03): 169-173.

Qiang Xin, Wenhao Zhu, Chuan He, Wenchen Li, Bo Chen, Haifeng Wang. Effect of glial cell-derived exosomal miRNAs on neuroinflammation after traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2024, 10(03): 169-173.

创伤性颅脑损伤（TBI）的进展是持续性的，脑组织受损可以激活神经胶质细胞，活化的神经胶质细胞通过外泌体介导的微小核糖核酸（miRNAs）对神经元发挥保护或毒性作用。神经胶质细胞分泌外泌体中的部分miRNAs可以减轻TBI后神经炎症，缓解继发性损伤，因此调节神经胶质细胞的活化有望改善TBI预后。本文围绕神经胶质细胞来源的外泌体miRNAs对TBI后神经炎症的影响展开综述，以期为相关神经炎症的治疗提供新的思路。

关键词: 神经胶质细胞, 外泌体, 创伤性颅脑损伤, 神经炎症

The progression of traumatic brain injury (TBI) is continuous, and damage to brain tissue can activate neuroglia, which can exert protective or toxic effects on neurons through exosome-mediated miRNAs. Secretion of some miRNAs from neuroglia in exosomes can reduce neuroinflammation after TBI and alleviate secondary cranial injury, therefore, regulating the activation of neuroglia is expected to improve the prognosis of TBI. This article reviews the effects of glial cell-derived exosome miRNAs on neuroinflammation after TBI to provide new ideas for the treatment of related neuroinflammation.

Key words: Glial cells, Exosomes, Traumatic brain injury, Neuroinflammation
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