The efficacy of mild hypothermia on endothelin in patients with severe brain injury

doi:10.3877/cma.j.issn.2095-9141.2016.01.004

Abstract

Abstract:

Objective

To evaluate the efficacy of mild hypothermia treatment on severe brain injury, and the regulating effect of plasma endothelin(ET).

Methods

Fifty patients with severe brain injury were divided into observation group(n=25) and control group(n=25). The control group was given to conventional therapy, and the observation group were given to conventional therapy combined with mild hypothermia. The plasma ET level, intracranial pressure(ICP) and clinical prognosis were compared between the two groups.

Results

After 1~5 days of treatment, the plasma ET level of observation group significantly lower than control group, the difference showed statistically significant(P<0.05). After 1~5 days of treatment, the ICP of observation group significantly lower than that of control group, the difference showed statistically significant(P<0.05). In observation group, favourable prognosis for 7 cases, mild disability for 8 cases, severe disability for 6 case, vegetable survival for 2 case and death 2 case. In control group, favourable prognosis for 3 cases, mild disability for 4 cases, severe disability for 10 case, vegetable survival for 3 cases and death 5 case. The clinical prognosis of observation group significantly better than control group, the difference showed statistically significant(P<0.05).

Conclusion

The brain protective effects of mild hypothermia may be related to the inhibition of ET secretion and reduce ICP.

Key words: Severe traumatic brain injury, Mild hypothermia, Endothelin

Hongying Lu, Weishui Lu, Chongqiao Qin, Songzuo Yu, Shi Tan, Wenjia Zhang, Mingzhen Zhou. The efficacy of mild hypothermia on endothelin in patients with severe brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(01): 15-18.

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References 14

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组别	n	入院时	第1天	第2天	第3天	第4天	第5天
观察组	25	105.9±8.3	111.8±11.4	94.2±9.5	84.1±5.3	77.2±6.8	62.8±7.4
对照组	25	107.4±7.8	136.3±9.2	119.4±8.1	102.8±6.2	90.3±5.7	78.2±5.1
t值	?	0.203	4.241	3.762	3.163	3.017	3.024
P值	?	0.849	0.035	0.039	0.044	0.045	0.045

组别	n	入院时	第1天	第2天	第3天	第4天	第5天
观察组	25	105.9±8.3	111.8±11.4	94.2±9.5	84.1±5.3	77.2±6.8	62.8±7.4
对照组	25	107.4±7.8	136.3±9.2	119.4±8.1	102.8±6.2	90.3±5.7	78.2±5.1
t值	?	0.203	4.241	3.762	3.163	3.017	3.024
P值	?	0.849	0.035	0.039	0.044	0.045	0.045

组别	n	入院时	第1天	第2天	第3天	第4天	第5天
观察组	25	24.7±2.3	22.4±2.0	19.1±3.1	17.1±3.3	16.0±2.8	15.2±2.4
对照组	25	24.2±2.1	23.3±1.8	23.0±2.1	21.2±2.4	19.5±2.3	18.2±3.1
t值	?	0.044	0.114	3.031	2.985	2.894	2.917
P值	?	0.967	0.915	0.045	0.048	0.049	0.049

组别	n	入院时	第1天	第2天	第3天	第4天	第5天
观察组	25	24.7±2.3	22.4±2.0	19.1±3.1	17.1±3.3	16.0±2.8	15.2±2.4
对照组	25	24.2±2.1	23.3±1.8	23.0±2.1	21.2±2.4	19.5±2.3	18.2±3.1
t值	?	0.044	0.114	3.031	2.985	2.894	2.917
P值	?	0.967	0.915	0.045	0.048	0.049	0.049

组别	n	良好	中残	重残	植物生存	死亡
观察组	25	7	8	6	2	2
对照组	25	3	4	10	3	5
Z值	?	2.159	?	?	?	?
P值	?	0.031	?	?	?	?

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