Diagnostic value of CD64 index combined with PCT, IL-6 and SAA test for intracranial bacterial infection after severe traumatic brain injury

doi:10.3877/cma.j.issn.2095-9141.2023.01.005

Abstract

Abstract:

Objective

To investigate the diagnostic value of CD64 index combined with procalcitonin (PCT), interleukin-6 (IL-6) and serum amyloid A (SAA) for intracranial bacterial infection after severe traumatic brain injury (sTBI).

Methods

Sixty patients with sTBI who had intracranial bacterial infection after receiving surgical treatment from October 2019 to January 2022 in Critical Medicine Department of Xuzhou Tumor Hospital were selected as the observation group, and 60 sTBI patients without intracranial bacterial infection after surgical treatment in the same period were selected as the control group. Their CD64 index, PCT, IL-6 and SAA level were detected respectively, and the combined diagnosis of CD64 index, PCT, IL-6 and SAA level in intracranial bacterial infection after sTBI was analyzed.

Results

Compared with the control group, the levels of CD64 index, PCT, IL-6 and SAA in the observation group were significantly higher after treatment, and the difference was statistically significant (P<0.05). Multivariate analysis showed that CD64 index, PCT, IL-6 and SAA were independent risk factors for intracranial infection in patients with sTBI after surgery (P<0.05); Compared with CD64 index, PCT, IL-6 and SAA, the sensitivity, specificity, positive predictive value and negative predictive value of the combined diagnosis of CD64 index+PCT+IL-6+SAA were significantly higher, and the difference was statistically significant (P<0.05).

Conclusion

After sTBI patients received surgical treatment, the combined detection of CD64 index, PCT, IL-6 and SAA levels can confirm whether the patients have intracranial bacterial infection and provide a reliable reference for subsequent treatment.

Key words: Severe traumatic brain injury, Neutrophil CD64 index, Procalcitonin, Interleukin-6, Serum amyloid A, Surgical treatment, Intracranial bacterial infection

Min Zhu, Faqiang Li. Diagnostic value of CD64 index combined with PCT, IL-6 and SAA test for intracranial bacterial infection after severe traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(01): 26-31.

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References 16

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项目	观察组（n=60）	对照组(n=60)	χ²/t值	P值
性别（男/女）	36/24	40/20	0.570	0.450
年龄（岁，±s）	53.66±5.23	54.12±5.26	0.482	0.632
损伤原因			0.312	0.523
交通事故伤	20	23
高处跌落伤	12	11
打击伤	15	17
其他损伤	13	9

项目	观察组（n=60）	对照组(n=60)	χ²/t值	P值
性别（男/女）	36/24	40/20	0.570	0.450
年龄（岁，±s）	53.66±5.23	54.12±5.26	0.482	0.632
损伤原因			0.312	0.523
交通事故伤	20	23
高处跌落伤	12	11
打击伤	15	17
其他损伤	13	9

指标		对照组（n=60）	观察组（n=60）	t值	P值
CD64指数	治疗前	2.12±0.32	2.16±0.35	-0.582	0.562
	治疗后	4.41±0.33	7.98±1.26	-21.231	<0.001
	t值	-33.764	-34.335
	P值	<0.001	<0.001
PCT（ng/mL）	治疗前	0.25±0.03	0.24±0.04	1.374	0.119
	治疗后	0.35±0.04	0.86±0.08	-46.000	<0.001
	t值	-14.420	-55.232
	P值	<0.001	<0.001
IL-6（ng/L）	治疗前	20.25±2.12	20.31±2.13	-0.149	0.882
	治疗后	31.42±2.36	68.54±4.26	-59.061	<0.001
	t值	3.321	8.634
	P值	<0.001	<0.001
SAA（mg/L）	治疗前	9.12±1.24	9.13±1.23	-0.037	0.970
	治疗后	49.43±4.43	102.54±10.26	-36.822	<0.001
	t值	-67.790	-70.445
	P值	<0.001	<0.001

指标		对照组（n=60）	观察组（n=60）	t值	P值
CD64指数	治疗前	2.12±0.32	2.16±0.35	-0.582	0.562
	治疗后	4.41±0.33	7.98±1.26	-21.231	<0.001
	t值	-33.764	-34.335
	P值	<0.001	<0.001
PCT（ng/mL）	治疗前	0.25±0.03	0.24±0.04	1.374	0.119
	治疗后	0.35±0.04	0.86±0.08	-46.000	<0.001
	t值	-14.420	-55.232
	P值	<0.001	<0.001
IL-6（ng/L）	治疗前	20.25±2.12	20.31±2.13	-0.149	0.882
	治疗后	31.42±2.36	68.54±4.26	-59.061	<0.001
	t值	3.321	8.634
	P值	<0.001	<0.001
SAA（mg/L）	治疗前	9.12±1.24	9.13±1.23	-0.037	0.970
	治疗后	49.43±4.43	102.54±10.26	-36.822	<0.001
	t值	-67.790	-70.445
	P值	<0.001	<0.001

变量	β	SE（β）	Wald χ²值	OR值	95%CI	P值
CD64指数	4.521	0.542	5.645	3.564	1.564~5.654	<0.001
PCT	2.654	0.412	4.123	3.234	1.356~5.645	<0.001
IL-6	3.345	0.465	4.642	3.645	1.654~6.345	<0.001
SAA	3.564	0.456	4.644	4.342	2.345~5.656	<0.001
常数项	1.725	0.456	5.654	-	-	<0.001

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