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中华神经创伤外科电子杂志 ›› 2022, Vol. 08 ›› Issue (05) : 307 -310. doi: 10.3877/cma.j.issn.2095-9141.2022.05.010

综述

外泌体及其miRNAs在常见神经损伤疾病中诊断和治疗作用的研究进展
高雅浩1, 韩光魁2, 姜迪3, 崔昌萌2,()   
  1. 1. 272067 济宁,济宁医学院临床医学院
    2. 272029 济宁,济宁医学院附属医院神经外科
    3. 250012 济南,山东大学齐鲁医学院
  • 收稿日期:2021-10-26 出版日期:2022-10-15
  • 通信作者: 崔昌萌
  • 基金资助:
    国家自然科学基金(81901954)

Diagnosis and treatment of exosomes and their miRNAs in the common nerve injury diseases

Yahao Gao1, Guangkui Han2, Di Jiang3, Changmeng Cui2,()   

  1. 1. Jining Medical College of Clinical Medicine, Jining 272067, China
    2. Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining 272029, China
    3. Cheeloo College of Medicine, Shandong University, Jinan 250012, China
  • Received:2021-10-26 Published:2022-10-15
  • Corresponding author: Changmeng Cui
引用本文:

高雅浩, 韩光魁, 姜迪, 崔昌萌. 外泌体及其miRNAs在常见神经损伤疾病中诊断和治疗作用的研究进展[J]. 中华神经创伤外科电子杂志, 2022, 08(05): 307-310.

Yahao Gao, Guangkui Han, Di Jiang, Changmeng Cui. Diagnosis and treatment of exosomes and their miRNAs in the common nerve injury diseases[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2022, 08(05): 307-310.

外泌体中的多种核酸和蛋白质等生物活性物质可充当信息分子,进行细胞间的信息交流和信息传递,从而调控疾病的发生发展过程。其中外泌体携带的miRNAs能通过血脑屏障发挥作用,具有高稳定性和高敏感性的特点,并且在调控神经发育和神经再生等生理和病理过程中都发挥着重要作用,因此可作为疾病诊断、预后甚至损伤情况的生物标志物,并且其对某些疾病也有一定的治疗作用。鉴于外泌体miRNAs参与了神经系统中大多数疾病的发生发展过程,本文将对外泌体及其miRNAs在常见神经损伤疾病中的诊断和治疗作用进行综述。

Bioactive substances such as nucleic acids and proteins in exosomes can act as information molecules, communicate and transmit information among cells, and thus regulate the occurrence and development of diseases. The miRNAs carried by exosomes can play a role through the blood-brain barrier, which has the characteristics of high stability and high sensitivity, and plays an important role in regulating physiological and pathological processes such as nerve development and nerve regeneration, so it can be used as a biomarker for disease diagnosis, prognosis and even injury, and has a certain therapeutic effect on some diseases. In view of the fact that exosomes miRNAs are involved in the occurrence and development of most diseases in the nervous system, this article reviews the diagnostic and therapeutic role of exosomes and their miRNAs in the common nerve injury diseases.

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