Research progress of multiple neuroprotective effects of brain-derived neurotrophic factor after central nervous system injury and its mechanism

doi:10.3877/cma.j.issn.2095-9141.2016.03.012

Abstract

Abstract:

Brain-derived neurotrophic factor(BDNF) has multiple neuroprotective effects after central nervous system injury, such as inhibiting apoptosis of neurons and oligodendrocytes, promoting the growth of synapse and the regeneration of axon, promoting the regeneration of myelin sheath, adjusting the immune response and nerve excitability after injury, and so on. This article reviewed the possible molecular mechanisms of the neuroprotective effect of BDNF, in order to indentify its application value in the clinic treatment.

Key words: Brain-derived neurotrophic factor, Neuroprotection, Central nervous system

Xinchao Ji, Ruxiang Xu. Research progress of multiple neuroprotective effects of brain-derived neurotrophic factor after central nervous system injury and its mechanism[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(03): 168-172.

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