Advance of the research on chronic traumatic encephalopathy

doi:10.3877/cma.j.issn.2095-9141.2020.04.012

Abstract

Abstract:

Chronic traumatic encephalopathy (CTE) is a neuropathological disease characterized by abnormal accumulation of phosphorylated tau protein in the brain. The currently recognized neuropathological standards are still preliminary, On one hand, they are based on a limited number of selected samples, and on the other hand, there are few studies that compare the pathology of CTE with other neurodegenerative diseases such as Alzheimer’s disease. In addition, CTE is widely considered to be the result of repeated head attacks, but a moderate or severe traumatic brain injury (TBI) can also induce CTE. Based on different viewpoints, this article summarizes the characteristics of CTE, research history, and the correlation between TBI and CTE based on domestic and foreign literature.

Key words: Chronic traumatic encephalopathy, Traumatic brain injury, Neuropathology

Xu Lu, Junli Yang, Na Wang, Qinye Zhou, Feng Fu. Advance of the research on chronic traumatic encephalopathy[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(04): 244-247.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsjcswkdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9141.2020.04.012

https://zhsjcswkdzzz.cma-cmc.com.cn/EN/Y2020/V06/I04/244

References 32

[1]	McKee AC, Stern RA, Nowinski CJ, et al. The spectrum of disease in chronic traumatic encephalopathy[J]. Brain, 2013, 136(Pt 1): 43-64.
[2]	Mez J, Daneshvar DH, Kiernan PT, et al. Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football[J]. JAMA, 2017, 318(4): 360-370.
[3]	Arman FZ. Chronic traumatic encephalopathy: a brief overview[J]. Front Neurol, 2019, 10: 713.
[4]	McKee AC, Stein TD, Kiernan PT, et al. The neuropathology of chronic traumatic encephalopathy[J]. Brain Pathol, 2015, 25(3): 350-364.
[5]	Jordan BD. The clinical spectrum of sport-related traumatic brain injury[J]. Nat Rev Neurol, 2013, 9(4): 222-230.
[6]	Stern RA, Daneshvar DH, Baugh CM, et al. Clinical presentation of chronic traumatic encephalopathy[J]. Neurology, 2013, 81(13): 1122-1129.
[7]	Smith DH, Victoria EJ, John Q, et al. Chronic traumatic encephalopathy-confusion and controversies[J]. Nat Rev Neurol, 2019, 15(3): 179-183.
[8]	Mawdsley C, Ferguson FR. Neurological disease in boxers[J]. Lancet, 1963, 2(7312): 795-801.
[9]	Brandenburg W, Hallervorden J. Dementia pugilistica with anatomical findings[J]. Virchows Arch Pathol Anat Physiol Klin Med, 1954, 325(6): 680-709.
[10]	Corsellis JA, Bruton CJ, Freeman-Browne D. The aftermath of boxing[J]. Psychol Med, 1973, 3(3): 270-303.
[11]	McKee AC, Cairns NJ, Dickson DW, et al. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy[J]. Acta Neuropathol, 2016, 131(1): 75-86.
[12]	Omalu BI, DeKosky ST, Minster RL, et al. Chronic traumatic encephalopathy in a National Football League player[J]. Neurosurgery, 2005, 57(1): 128-134; discussion 128-134.
[13]	Ropper AH. Links in the chain of chronic traumatic encephalopathy[J]. N Engl J Med, 2019, 380(18): 1771-1772.
[14]	Stewart W, McNamara PH, Lawlor B, et al. Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?[J]. QJM, 2016, 109(1): 11-15.
[15]	Ling H, Morris HR, Neal JW, et al. Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players[J]. Acta Neuropathol, 2017, 133(3): 337-352.
[16]	McKee AC, Cantu RC, Nowinski CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury[J]. J Neuropathol Exp Neurol, 2009, 68(7): 709-735.
[17]	Falcon B, Zivanov J, Zhang W, et al. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules[J]. Nature, 2019, 568(7752): 420-423.
[18]	Stern RA, Adler CH, Chen K, et al. Tau positron-emission tomography in National Football League players[J]. N Engl J Med, 2019, 380(18): 1716-1725.
[19]	Johnson VE, Stewart W, Smith DH. Traumatic brain injury and amyloid-β pathology: a link to Alzheimer’s disease?[J]. Nat Rev Neurosci, 2010, 11(5): 361-370.
[20]	Roberts GW, Allsop D, Bruton C. The occult aftermath of boxing[J]. J Neurol Neurosurg Psychiatry, 1990, 53(5): 373-378.
[21]	Stein TD, Montenigro PH, Alvarez VE, et al. Beta-amyloid deposition in chronic traumatic encephalopathy[J]. Acta Neuropathol, 2015, 130(1): 21-34.
[22]	Josephs KA, Dickson DW, Tosakulwong N, et al. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer’s disease: a longitudinal retrospective study[J]. Lancet Neurol, 2017, 16(11): 917-924.
[23]	Deng Z, Lim J, Wang Q, et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway[J]. Autophagy, 2020, 16(5): 917-931.
[24]	McKee AC, Gavett BE, Stern RA, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy[J]. J Neuropathol Exp Neurol, 2010, 69(9): 918-929.
[25]	Saing T, Dick M, Nelson PT, et al. Frontal cortex neuropathology in dementia pugilistica[J]. J Neurotrauma, 2012, 29(6): 1054-1070.
[26]	Sidaros A, Skimminge A, Liptrot MG, et al. Long-term global and regional brain volume changes following severe traumatic brain injury: a longitudinal study with clinical correlates[J]. Neuroimage, 2009, 44(1): 1-8.
[27]	Xu Y, McArthur DL, Alger JR, et al. Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury[J]. J Cereb Blood Flow Metab, 2010, 30(4): 883-894.
[28]	Johnson VE, Stewart W, Smith DH. Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans[J]. Brain Pathol, 2012, 22(2): 142-149.
[29]	Chen XH, Siman R, Iwata A, et al. Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma[J]. Am J Pathol, 2004, 165(2): 357-371.
[30]	Ikonomovic MD, Uryu K, Abrahamson EE, et al. Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury[J]. Exp Neurol, 2004, 190(1): 192-203.
[31]	Smith DH, Stewart W. Traumatic brain injury: a platform for studies in Aβ processing: commentary on: "Rapid Aβ oligomer and protofibril accumulation in traumatic brain injury" [J]. Brain Pathol, 2018, 28(4): 463-465.
[32]	Wang HK, Lee YC, Huang CY, et al. Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis[J]. Neuroscience, 2015, 300: 94-103.

Please choose a citation manager

Content to export