To analyze the clinical risk factors of intracranial infection after operation of intracranial aneurysm and to explore the clinical application value of cerebrospinal fluid (CSF) and serum indexes in intracranial infection.

A retrospective study was conducted on 213 patients with intracranial aneurysms treated in neurosurgery department of Huanghua People’s Hospital from August 2014 to March 2016. According to be infected or not, they were divided into two groups: 28 patients with intracranial infection and 185 patients without intracranial infection. The clinical baseline data of the two groups were compared, and the risk factors of intracranial infection were analyzed by multivariate Logistic regression analysis. The CSF index and serological index of the two groups were compared. The correlation between the two groups and intracranial infection was analyzed by Spearman correlation test.

Multivariate Logistic regression analysis showed that diabetes mellitus, ruptured aneurysm, CSF leakage, intraoperative hemorrhage over 100 mL and operation time >4 h were independent risk factors for intracranial infection. The level of CSF and serum in the intracranial infection group was higher than that in the non intracranial infection group, and there was a positive correlation between CSF and serum and intracranial infection.

Hyperglycemia, ruptured aneurysm, CSF leakage, intraoperative hemorrhage over 100 mL and operation time over 4 h are all risk factors of postoperative intracranial infection. The detection of CSF and serological indexes can help the diagnosis of postoperative intracranial infection of intracranial aneurysm.