To explore the susceptible factors and prevention of occurrence ofintracranial infection after craniotomy.

From 2010 August to 2014 August, the craniocerebral operation was performed in 143 patients, the clinical data including 21 cases of intracranial infection patients were analyzed. t test and logistic regression were used to analyze the relationship between the factors and intracranial infection.

Single factor analysis showed that the incidence of postoperative infections was related to advanced age of patients, preoperative GCS, combined with diabetes mellitus, long-time operation (> 4 h), and intracranial pressure monitoring days (P<0.05). Multivariate logistic regression analysis showed that advanced age of patients, preoperative GCS, long-time operation (>4 h), and intracranial pressure monitoring days were independent factors for secondary intracranial infection after intracranial pressure monitoring in craniocerebral operation.

The intracranial infection can be effectively controlled by strengthening nutrition support among elderly patients, shortening the operation time, early removing intracranial pressure sensor, strengthening antibiotic management in peri operation period, and strict aseptic operation.