| [1] |
Hirokawa N,Funakoshi T,Sato-Harada R, et al. Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons[J]. J Cell Biol, 1996, 132(4): 667-679.
|
| [2] |
Ittner LM,Ke YD,Delerue F, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models[J]. Cell, 2010, 142(3): 387-397.
|
| [3] |
Zempel H,Luedtke J,Kumar Y, et al. Mandelkow E M Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin[J]. EMBO J, 2013, 32(22): 2920-2937.
|
| [4] |
Hanger DP,Anderton BH,Noble W. Tau phosphorylation: The therapeutic challenge for neurodegenerative disease[J]. Trends Mol Med, 2009, 15(3): 112-119.
|
| [5] |
Santacruz K,Lewis J,Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function[J]. Science, 2005, 309(5733): 476-481.
|
| [6] |
Andrews-Zwilling Y,Bien-Ly N,Xu Q, et al. Apolipoprotein E4 causes age-and tau-dependent impairment of GABAergic interneurons leading to learning and memory deficits in mice[J]. J Neurosci, 2010, 30(41): 13707-13717.
|
| [7] |
Jho YS,Zhulina EB,Kim MW, et al. Monte carlo simulations of tau proteins: Effect of phosphorylation[J]. Biophys J, 2010, 99(8): 2387-2397.
|
| [8] |
Fischer D,Mukrasch MD,Biernat J, et al. Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules[J]. Biochemistry, 2009, 48(42): 10047-10055.
|
| [9] |
Dolan PJ,Johnson GV. The role of tau kinases in Alzheimer’s disease [J]. Curr Opin Drug Discov Devel, 2010, 13(5): 595-603.
|
| [10] |
Wang QM,Fiol CJ,DePaoli-Roach AA, et al. Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation[J]. Biol Chem, 1994, 269(20): 14566-14574.
|
| [11] |
Dhavan R,Tsai LH. A decade of CDK5[J]. Nat Rev Mol Cell Biol, 2001, 2(10): 749-759.
|
| [12] |
Lee MS,Kwon YT,Li M, et al. Neurotoxicity induces cleavage of p35 to p25 by calpain[J]. Nature, 2000, 405(6784):360-364.
|
| [13] |
Vingtdeux V,Davies P,Dickson DW, et al. AMPK is abnormally activated in tangle-and pre-tangle-bearing neurons in Alzheimer disease and other tauopathies. Acta Neuropathol, 2011, 121(3): 337-349.
|
| [14] |
Gustke N,Steiner B,Mandelkow EM, et al.The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. FEBS Lett, 1992, 307(2): 199-205.
|
| [15] |
Majounie E,Cross W,Newsway V, et al. Variation in tau isoform expression in different brain regions and disease states[J]. Neurobiol Aging, 2013, 34(7): 1922.e7-1922.e12.
|
| [16] |
Ittner LM,Götz J. Amyloid-β and tau--A toxic pas de deux in Alzheimer’s disease[J]. Nat Rev Neurosci, 2011, 12(2):67-72.
|
| [17] |
Woehlke G,SchliwaM, Walking on two heads: the many talents of kinesin[J]. Nat. Rev Mol Cell Biol, 2000, 1(1): 50-58.
|
| [18] |
Toomre D,Manstein DJ. Lighting up the cell surface with evanescent wave microscopy[J]. Trends Cell Biol, 2001, 11(7): 298-303.
|
| [19] |
Ledesma MD,Medina M,Avila J. The in vitro formation of recombinant tau polymers: Effect of phosphorylation and glycation[J]. Mol Chem Neuropathol, 1996, 27(3): 249-258.
|
| [20] |
Hardy J,Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics[J]. Science, 2002, 297(5580): 353-356.
|
| [21] |
Hamdane M,Dourlen P,Bretteville A, et al. Pin1 allows for differential Tau dephosphorylation in neuronal cells[J]. Mol Cell Neurosci, 2006, 32(1-2): 155-160.
|
| [22] |
Miyata Y,Koren J,Kiray J, et al. Molecular chaperones and regulation of tau quality control:strategies for drug discovery in tauopathies[J]. Future Med Chem, 2011, 3(12): 1523-1537.
|
| [23] |
Whiteman IT,Gervasio OL,Cullen KM, et al. Activated ADF/cofilin sequesters phosphorylated microtubuleassociated-protein during the assembly of Alzheimer-like neuritic cytoskeletal striations[J]. J Neurosci, 2009, 29(41): 129-134.
|
| [24] |
Hyman BT,Augustinack JC,Ingelsson M. Transcriptional and conformational changes of the tau molecule in Alzheimer’s disease[J]. Biochim Biophys Acta, 2005, 1739(2-3): 150-157.
|
| [25] |
Feuillette S,Miguel L,Frébourg T, et al. Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein[J]. J Neurochem, 2010, 113(4): 895-903.
|
| [26] |
Haase C,Stieler JT,Arendt T, et al. Pseudophosphorylation of tau protein alters its ability for self-aggregation[J]. Neurochem, 2004, 88(6): 1509-1520.
|
| [27] |
Stokin GB,Goldstein LS. Axonal transport and Alzheimer’s disease [J]. Annu Rev Biochem, 2006, 75: 607-627.
|
| [28] |
Reynolds CH,Betts JC,Blackstock WP, et al. Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2 c-Jun N-terminal kinase and P38 and glycogen synthase kinase-3beta[J]. J Neurochem, 2000, 74(4): 1587-1595.
|
| [29] |
Mandelkow EM,Mandelkow E. Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration[J]. Cold Spring Harb Perspect Med, 2012, 2(7): a006247.
|
| [30] |
Johnson GV,Stoothoff WH. Tau phosphorylation in neuronal cell function and dysfunction[J]. J Cell Sci, 2004, 117(Pt24): 5721-5729.
|
| [31] |
Spires-Jones TL,Stoothoff WH. Tau pathophysiology in neurodegeneration: A tangled issue[J]. Trends Neurosci, 2009, 32(3): 150-159.
|
| [32] |
Billingsley ML,Kincaid RL. Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction intracellular trafficking and neurodegeneration[J]. Biochem J, 2009, 16(Pt3): 409-427.
|
| [33] |
Zemlan FP,Rosenberg WS,Luebbe PA, et al. Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau proteins[J]. J Neuro Chem, 1999, 72(2): 741-750.
|