目的

比较两种血糖目标值的胰岛素强化治疗方案治疗神经外科应激性高血糖患者的疗效。

方法

对2010年1月至2014年10月收住北京军区261医院神经外科的56例符合应激性高血糖诊断标准的颅脑外伤患者分为两组给予不同血糖目标值的胰岛素强化治疗，低目标值组(Leuven方案组)将血糖控制在4.4～6.1 mmol/L水平，高目标值组将血糖控制在6.2～8.9 mmol/L水平。

结果

比较两组患者的死亡率、MOF发病率、ICU住院日、感染发生率均无明显差别，高目标值组低血糖发生率明显降低。

结论

两种血糖目标值的胰岛素强化治疗方法的初步临床疗效比较并无统计学差异，但低目标值组低血糖发生率明显较高。高目标值法更适于临床应用。

Objective

To compare the curative effects of two intensive insulin therapies with different blood glucose target on patients with stress hyperglycemia after craniocerebral trauma.

Methods

Fifty-six traumatic patients enrolled from January 2010 to October 2014 were divided randomly in two groups with different blood glucose targets:4.4～6.1mmol/L in the low-target group(Leuven Method)and 6.2～8.9mmol/L in the high～target group.

Results

The mortality rates,incidence of MOF,duration in ICU and Infection incidences of the two groups have no significant difference,and the incidence of hypoglycemia is low in high-target group.

Conclusions

There is no significant difference in the two group of target-valued intensive insulin therapy methods as far as preliminary clinical curative effect is concerned.Because the incidence of hypoglycemia is high in low-target group,the high-target-valued method is more suitable for clinical appliance.