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中华神经创伤外科电子杂志 ›› 2015, Vol. 01 ›› Issue (03) : 173 -177. doi: 10.3877/cma.j.issn.2095-9141.2015.03.012

专题笔谈

高迁移率族蛋白B1与脑损伤研究进展
孙恺1, 王翀2,()   
  1. 1.261053 潍坊,潍坊医学院
    2.272011 济宁,山东济宁市第一人民医院
  • 收稿日期:2015-04-26 出版日期:2015-06-15
  • 通信作者: 王翀
  • 基金资助:
    山东省自然科学基金面上项目(ZR2011HM061)济南市科技局2008科技发展计划项目(20087032-3)

Research progress on high mobility group protein B1 and craniocerebral injury

Kai Sun1, Chong Wang2,()   

  1. 1.Department of Neurosurgery, Weifang Medical University, Weifang 261053, Shandong, China
    2.Department of Neurosurgery, Shandong Jining No.1 People's Hospital, Jining 272011,Shandong,China
  • Received:2015-04-26 Published:2015-06-15
  • Corresponding author: Chong Wang
引用本文:

孙恺, 王翀. 高迁移率族蛋白B1与脑损伤研究进展[J]. 中华神经创伤外科电子杂志, 2015, 01(03): 173-177.

Kai Sun, Chong Wang. Research progress on high mobility group protein B1 and craniocerebral injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2015, 01(03): 173-177.

高迁移率族蛋白B1(HMGB1)为真核细胞核内的一种高度保守的非组蛋白,既可以由坏死的细胞释放出来,也可以由炎症细胞主动释放到细胞外来发挥致炎作用。近来,越来越多的研究发现,HMGB1在创伤性脑损伤、缺血性脑损伤和出血性脑损伤的发生发展过程中起到多种重要作用。本文就HMGB1的概述及其在脑损伤病理机制当中发挥的作用予以综述。

High mobility group box-1 (HMGB1) is a highly conserved nonhistone nuclear protein that contributes to the architecture of chromatin DNA. HMGB1 is actively secreted by inflammatory cells or released by necrotic cells into the extracellular milieu,where it might be involved in the triggering of inflammation. Nowadays, an increasing number of researches discovered that HMGB1 do play an important role in the genesis and development process of traumatic brain injury,ischemic brain injury and hemorrhagic brain injury.This review summarized the overview of HMGB1 and its roles playing in the mechanism of brain injury.

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