Correlation of serum GFAP, NSE and national institute of health stroke scale in patients with traumatic brain injury

doi:10.3877/cma.j.issn.2095-9141.2018.06.004

Abstract

Abstract:

Objective

To investigate the serum glial fibrillary acidic protein (GFAP) and neuron specific enolase (NSE) level changes in traumatic brain injury (TBI) patients, and according to the prognosis of national institute of health stroke scale (NIHSS) scores for correlation analysis.

Methods

One hundred and forty cases of TBI were selected, 140 patients were divided into control group (20 cases, NIHSS 0-1 scores), mild injury group (40 cases, NIHSS 2-15 scores), moderate injury group (40 cases, NIHSS 16-20 scores), and severe injury grou (40 cases, NIHSS 21-42 scores) according to NIHSS. The corresponding treatments were given in the hospital, the concentrations of GFAP and NSE at different time points by enzyme-linked immunosorbent assay were monitored. The change trend between the two indicators in patients with different injury levels (NIHSS score) was compared, and the correlation between the two indicators and the NIHSS level was analyzed.

Results

Serum GFAP and NSE levels were significantly higher in the patients with the three groups than the control group (P<0.05). There were significant differences in GFAP and NSE levels among mild, moderate and severe groups at different time periods (P<0.05), and significant increases in GFAP and NSE concentrations in the severe group. The levels of serum GFAP and NSE were positively correlated with NHISS scores (r=0.484, 0.447, P<0.05).

Conclusion

The levels of serum GFAP and NSE in patients with TBI are closely related to the degree of NIHSS scores, which can be used to assess the severity of disease progression and neurological deficits with dynamic monitoring.

Key words: Traumatic brain injury, Glial fibrillary acidic protein, Neuron specific enolase, National institute of health stroke scale

Zongpei Guo, Hongtian Zhang, Xifa Wei, Likun Xiang, Yinshan Zhang, Zhiying Zhao, Dacheng Ma. Correlation of serum GFAP, NSE and national institute of health stroke scale in patients with traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2018, 04(06): 333-336.

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组别	例数	GFAP	NSE
对照组	20	8.4±3.2	23.6±8.7
轻度组	40	10.5±3.6^a	21.9±5.7^a
中度组	40	15.1±4.1^ab	39.4±8.5^ab
重度组	40	17.5±4.6^abc	46.8±6.7^abc
F值	?	4.325	9.827
P值	?	0.001	0.001

组别	例数	GFAP	NSE
对照组	20	8.4±3.2	23.6±8.7
轻度组	40	10.5±3.6^a	21.9±5.7^a
中度组	40	15.1±4.1^ab	39.4±8.5^ab
重度组	40	17.5±4.6^abc	46.8±6.7^abc
F值	?	4.325	9.827
P值	?	0.001	0.001

组别	GFAP（ng/mL）				NSE（ng/mL）
组别	24 h内	48 h	72 h	120 h	24 h内	48 h	72 h	120 h
轻度组	8.1±2.4	10.3±3.7	12.2±4.2	11.6±3.2	19.3±5.8	22.3±3.5	24.7±4.8	21.1±8.3
中度组	10.3±4.5^a	13.7±4.2^a	16.5±3.7^a	19.8±5.2^a	31.5±7.2^a	36.1±8.3^a	48.6±9.2^a	41.3±7.2^a
重度组	10.5±4.6^ab	16.1±3.6^ab	20.3±3.7^ab	23.5±4.1^ab	32.4±3.5^ab	40.5±6.7^ab	53.9±7.6^ab	60.3±6.8^ab
F值	0.729	2.271	4.598	5.583	4.823	6.383	9.813	22.434
P值	0.043	0.023	0.013	0.008	0.024	0.007	0.003	0.001

组别	GFAP（ng/mL）				NSE（ng/mL）
组别	24 h内	48 h	72 h	120 h	24 h内	48 h	72 h	120 h
轻度组	8.1±2.4	10.3±3.7	12.2±4.2	11.6±3.2	19.3±5.8	22.3±3.5	24.7±4.8	21.1±8.3
中度组	10.3±4.5^a	13.7±4.2^a	16.5±3.7^a	19.8±5.2^a	31.5±7.2^a	36.1±8.3^a	48.6±9.2^a	41.3±7.2^a
重度组	10.5±4.6^ab	16.1±3.6^ab	20.3±3.7^ab	23.5±4.1^ab	32.4±3.5^ab	40.5±6.7^ab	53.9±7.6^ab	60.3±6.8^ab
F值	0.729	2.271	4.598	5.583	4.823	6.383	9.813	22.434
P值	0.043	0.023	0.013	0.008	0.024	0.007	0.003	0.001

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