Effect of hyperbaric oxygen treatment on neurological function and serum hs-CRP in patients with hypertensive intracerebral hemorrhage

doi:10.3877/cma.j.issn.2095-9141.2018.01.008

Abstract

Abstract:

Objective

To observe the effect of hyperbaric oxygen (HBO) treatment applied to patients with hypertensive intracerebral hemorrhage (HICH) on neurological function and serum hypersensitive C-reactive protein (hs-CRP).

Methods

Seventy-eight patients with HICH were randomly divided into hyperbaric oxygen (HBO) treatment group (n=42) and routine treatment (control) group (n=36). The control group was treated with conventional treatment, including craniotomy, blood pressure control, dehydration to reduce intracranial pressure and nerves nutrition. On the basis of control group, the HBO treatment group was treated with HBO therapy at the fifth day after craniotomy and lasted 20 d. The curative effects and serum hs-CRP were compared between the HBO therapy and control groups before and after treatment.

Results

After treatment, the curative effects were significantly higher in HBO treatment group than those in the control group (P<0.05). As compared with that before treatment, cerebral edema volume and serum hs-CRP level were obviously reduced after treatment (P<0.05) both in HBO treatment group and control group. And there were statistically significant difference in HBO treatment group and control group after treatment. Additionally, there were significant positive correlation between cerebral edema volume and serum hs-CRP levels (P<0.05).

Conclusion

Early treatment with hyperbaric oxygen can significantly promote the recovery of neurological function, alleviate the degree of cerebral edema and reduce the level of serum hs-CRP in patients with HICH.

Key words: Hypertensive intracerebral hemorrhage, Hyperbaric oxygen, Neurological function, Hypersensitive C-reactive protein

Junqing Shao, Xiaofei Chen, Yi Li, Junlin Mo, Shunjiang Lin. Effect of hyperbaric oxygen treatment on neurological function and serum hs-CRP in patients with hypertensive intracerebral hemorrhage[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2018, 04(01): 29-32.

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References 15

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组别	例数	基本痊愈	显著进步	进步	无效	恶化	总有效率
高压氧组	42	10	19	9	3	1	90.48%
对照组	36	6	9	14	5	2	80.56%
Z值	?	?	?	?	?	?	-2.081
P值	?	?	?	?	?	?	0.037

组别	例数	基本痊愈	显著进步	进步	无效	恶化	总有效率
高压氧组	42	10	19	9	3	1	90.48%
对照组	36	6	9	14	5	2	80.56%
Z值	?	?	?	?	?	?	-2.081
P值	?	?	?	?	?	?	0.037

组别	例数	入院时(mL)	术后第5天(mL)	疗程结束后(mL)
高压氧组	42	12.67±3.23	20.31±4.35	9.13±2.22^a
对照组	36	11.94±3.19	19.67±4.59	10.39±2.86^a
t值	?	1.001	0.631	2.188
P值	?	0.320	0.530	0.032

组别	例数	入院时(mL)	术后第5天(mL)	疗程结束后(mL)
高压氧组	42	12.67±3.23	20.31±4.35	9.13±2.22^a
对照组	36	11.94±3.19	19.67±4.59	10.39±2.86^a
t值	?	1.001	0.631	2.188
P值	?	0.320	0.530	0.032

组别	例数	入院时(mg/L)	术后第5天(mg/L)	疗程结束后(mg/L)
高压氧组	42	16.06±2.74	49.31±8.39	13.53±2.12^a
对照组	36	16.42±2.89	48.87±7.62	14.97±2.73^a
t值	?	0.564	0.241	2.619
P值	?	0.574	0.810	0.011

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