Research progress of mechanism about the secondary coagulation dysfunction following the traumatic brain injury

doi:10.3877/cma.j.issn.2095-9141.2016.05.010

Abstract

Abstract:

Coagulant abnormality can occur secondary to traumatic brain injury (TBI) . The mechanism includes platelet dysfunction, abnormal activation of UPA/TPA, brain-derived microparticulars (BDMP) , activation of protein C system, release of tissue factors (TF) , change of blood coagulation factor Ⅶ activity, etc. In this review, recently researches were briefly reviewed to illuminate the possible mechanisms of this secondary coagulant abnormality in the different phases of TBI.

Key words: Traumatic brain injury, Coagulation abnormalities, Research progress

Tianfei Li, Jun Li, Liangfeng Wei, Shousen Wang. Research progress of mechanism about the secondary coagulation dysfunction following the traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(05): 302-304.

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