To investigate the clinical effect of β-aescinate sodium combined with glycerin fructose in the treatment of cerebral hemorrhage.

A total of 87 patients with cerebral hemorrhage diagnosed and treated by Neurosurgery Department of Ya'an Hospital of Traditional Chinese Medicine from May 2018 to May 2020 were prospectively selected as research objects. According to the random number table method, they were randomly divided into the observation group (treated with β-aescinate sodium combined with glycerol fructose, n=43) and the control group (treated with glycerol fructose, n=44). The National Institute of Health stroke scale (NIHSS) score, GCS score, Barthel index (BI), NO, matrix metalloproteinase-9 (MMP-9), tumor necrosis factor-α (TNF-α), and cerebral hematoma volume of the two groups were compared.

The total effective rate of the observation group (90.70%) was higher than that of the control group (63.64%), and the difference was statistically significant (P<0.05). Repeated-measures analysis of variance showed that the comparison of time effect, intergroup effect, time and group interaction of NIHSS score, GCS score, BI score, NO, TNF-α, MMP-9, cerebral hematoma volume between the two groups was statistically significant (P<0.05). Pairwise comparison showed that before treatment, there was no significant difference in NIHSS score, GCS score, BI score, NO, TNF-α, MMP-9, and cerebral hematoma volume between the two groups (P>0.05); after 1 and 2 weeks of treatment, the NIHSS score, TNF-α, MMP-9, and cerebral hematoma volume in the observation group were lower than those in the control group, while the GCS score, BI score, and NO were higher than those in the control group (P<0.05).

β-Aescinate sodium combined with glycerol fructose has a significant effect on the treatment of cerebral hemorrhage, which can not only improve nerve function, but also reduce the expression of TNF-α and MMP-9.