Research progress of lncRNA in traumatic brain injury

doi:10.3877/cma.j.issn.2095-9141.2022.06.010

Abstract

Abstract:

Traumatic brain injury (TBI) has a very high morbidity, disability and mortality rate in global. Due to the complexity, multi-level, heterogeneity and other factors of its pathological mechanism, poor effect of conventional clinical treatment brings a huge burden to individuals, families and society. Long noncoding RNA (lncRNA) is a type of RNA with a length of more than 200 nt, which is closely related to the occurrence and development of various signal transduction, inflammation pathways, immune response, ion channels and cell cycle in TBI. This article mainly reviews the role of lncRNA in TBI through inflammatory pathway and immune-related inflammation in TBI, in order to bring new opportunities for the treatment of TBI patients by regulating the expression level of lncRNA.

Key words: Traumatic brain injury, Long noncoding RNA, Inflammatory pathway, Immune response

Jianpeng Wang, Yongshi Liao, Wencong Ding, Chong Li, Rui Chen. Research progress of lncRNA in traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2022, 08(06): 365-370.

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