Research advances in neuroimmunomodulatory function of exosomes in spinal cord injury repair

doi:10.3877/cma.j.issn.2095-9141.2021.05.011

Abstract

Abstract:

Spinal cord injury (SCI) is a temporary or permanent loss of motor, sensory and autonomic nerve functions below the body due to the destruction of the integrity of the spinal cord under the action of external factors. Exosomes are extracellular vesicles with a diameter of 40 to 100 nm secreted by cells themselves. They can be used as transport carriers to participate in intercellular signal transduction in immune response and effectively reduce spinal cord nerve cell injury. At present, the specific role of immune cells and exosomes in SCI and the mechanism of their effect on subsequent inflammation remain unclear. The purpose of this review is to explore the mechanism of neuro-immune regulation of immune cells and exosomes after SCI, as well as new therapeutic targets and new schemes for improved healing.

Key words: Spinal cord injury, Exosomes, Neuro-immune

Hua Ding, Lei Zhang, Jishan Yuan, Xiaochen Fan, Xiang Yao, Bin Lyu. Research advances in neuroimmunomodulatory function of exosomes in spinal cord injury repair[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2021, 07(05): 305-309.

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