Clinical application effect of hyperbaric oxygen combined with nalmefene on diffuse axonal injury

doi:10.3877/cma.j.issn.2095-9141.2021.05.010

Abstract

Abstract:

Objective

To study the clinical application effect of hyperbaric oxygen (HBO) combined with nalmefene on wake-promoting therapy in patients with diffuse axonal injury (DAI).

Methods

A total of 160 patients with DAI admitted to the Neurosurgery and Emergency Department of Affiliated Hospital 2 of Nantong University from August 2012 to August 2019 were randomly divided into routine treatment group, HBO treatment group, nalmefene treatment group and HBO combined with nalmefene treatment group, with 40 cases in each group. The patients were followed up for 3 months. The treatment effect was evaluated by GOS score, and the good prognosis rate of 4 groups was compared.

Results

The good prognosis rate of HBO combined with nalmefene treatment group was higher than in routine treatment group, the difference was statistically significant (P<0.05).

Conclusion

HBO combined with nalmefene could promote the recovery of consciousness, accelerate waking up and improve their living condition of the patients with a DAI coma.

Key words: Diffuse axon injury, Hyperbaric oxygen, Nalmefene, Coma, Wake-promoting

Xuejian Wang, Zhifeng Wang, Feng Li. Clinical application effect of hyperbaric oxygen combined with nalmefene on diffuse axonal injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2021, 07(05): 301-304.

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References 15

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组别	例数	良好	轻残	重残及以上	良好率（%）
常规治疗组	37	9	15	13	24.3
HBO治疗组	37	13	17	7	35.1
纳美芬治疗组	36	12	15	9	33.3
HBO联合纳美芬治疗组	38	19	12	7	50.0^a
H值					13.447
P值					0.004

组别	例数	良好	轻残	重残及以上	良好率（%）
常规治疗组	37	9	15	13	24.3
HBO治疗组	37	13	17	7	35.1
纳美芬治疗组	36	12	15	9	33.3
HBO联合纳美芬治疗组	38	19	12	7	50.0^a
H值					13.447
P值					0.004

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