Neuropeptide Y expression differences of Palmini pathological subtypes in human brain focal cortical dysplasia

doi:10.3877/cma.j.issn.2095-9141.2021.05.008

Abstract

Abstract:

Objective

To explore neuropeptide Y (NPY) expression differences in different pathological subtypes of human brain focal cortical dysplasia (FCD) and in normal human brain, and the mechanism by which FCD induced epilepsy.

Methods

Fifty-eight patients with FCD were collected from the Department of Neurosurgery of Hebei Provincial People’s Hospital from May 2007 to October 2011. According to Palmini classification criteria of different pathological subtypes, they were divided into 4 groups: 9 cases in group ⅠA, 26 cases in group ⅠB, 10 cases in group ⅡA and 13 cases in group ⅡB. While 10 normal human brain tissues were taken as the control group. The clinical characteristics of epilepsy in patients with FCD and the differences in the number of positive NPY immunoreactive cells between patients with FCD and normal human brain were observed.

Results

The frequency of seizures in FCDⅡB group was significantly higher than in the other pathological subtypes. The number of NPY immunoreactive cells in FCDⅡB group was significantly increased compared with the control group, the difference was statistically significant (P<0.05); There was no significant difference in FCDⅠA, FCDⅠB and FCDⅡA subtypes between FCD group and control group (P>0.05).

Conclusion

The NPY immunoreactive cells of FCDⅡB were significantly positive in all pathological subtypes of FCD. FCDⅡB epileptogenic mechanism may be related to the increased expression of NPY.

Key words: Focal cortical dysplasia, Neuropeptide Y, Pathological subtypes, Epilepsy

Hui Liu, Jixiang Liu, Shaoping Zhan, Wenling Li, Jiang Wu, Yongjun Liu, Peng Zhang, Lun Shen, Jianhua Li. Neuropeptide Y expression differences of Palmini pathological subtypes in human brain focal cortical dysplasia[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2021, 07(05): 293-296.

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References 16

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组别	例数	发病年龄（岁，±s）	发作形式[例（%）]			发作频率（次/月，±s）
组别	例数	发病年龄（岁，±s）	简单部分性发作	复杂部分性发作	继发全面强直阵挛发作	发作频率（次/月，±s）
FCDⅠA组	9	9.4±1.3	6（66.7）	5（55.6）	5（55.6）	1.2±0.7^a
FCDⅠB组	26	9.2±1.7	16（61.5）	16（61.5）	14（53.8）	1.3±0.8^a
FCDⅡA组	10	9.3±1.1	6（60.0）	6（60.0）	5（50.0）	2.1±0.9^a
FCDⅡB组	13	9.3±1.5	8（61.5）	8（61.5）	6（46.2）	4.1±1.2
F/χ²值		0.040	1.567	0.592	1.009	30.660
P值		0.988	0.667	0.898	0.799	<0.001

组别	例数	发病年龄（岁，±s）	发作形式[例（%）]			发作频率（次/月，±s）
组别	例数	发病年龄（岁，±s）	简单部分性发作	复杂部分性发作	继发全面强直阵挛发作	发作频率（次/月，±s）
FCDⅠA组	9	9.4±1.3	6（66.7）	5（55.6）	5（55.6）	1.2±0.7^a
FCDⅠB组	26	9.2±1.7	16（61.5）	16（61.5）	14（53.8）	1.3±0.8^a
FCDⅡA组	10	9.3±1.1	6（60.0）	6（60.0）	5（50.0）	2.1±0.9^a
FCDⅡB组	13	9.3±1.5	8（61.5）	8（61.5）	6（46.2）	4.1±1.2
F/χ²值		0.040	1.567	0.592	1.009	30.660
P值		0.988	0.667	0.898	0.799	<0.001

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