Anti-inflammatory mechanism of nerve growth factor in traumatic brain injury

doi:10.3877/cma.j.issn.2095-9141.2020.06.012

Abstract

Abstract:

Traumatic brain injury (TBI) is a common traumatic disease in neurosurgery. TBI patients will suffer secondary injury in the local injury caused by immune-inflammatory waterfall reaction, and even some patients will have severe symptoms of nerve function loss. Therefore, in the treatment of TBI patients, it is particularly important to combine injury repair therapy with anti-inflammatory repair therapy. Nerve growth factor (NGF) is the first discovered and most widely studied neurogenic growth factor, which was widely believed to play an important role in nerve regeneration and injury repair. Meanwhile, more and more studies have shown that NGF can interact with receptors on the surface of immune cells to play a corresponding anti-inflammatory role in recent years. Therefore, this paper focuses on the anti-inflammatory effect of NGF in the treatment of TBI, in order to provid some reference for the follow-up study and treatment.

Key words: Nerve growth factor, Traumatic brain injury, Anti-inflammatory, Signaling pathway

Wenhao Zhu, Wenchen Li, Bo Chen, Haifeng Wang. Anti-inflammatory mechanism of nerve growth factor in traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(06): 377-380.

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