Effects of hyperbaric oxygen combined with Oxiracetam on cognitive function and related cytokines in patients after brain trauma

doi:10.3877/cma.j.issn.2095-9141.2019.06.007

Abstract

Abstract:

Objective

To investigate the effect of hyperbaric oxygen combined with Oxiracetam on cognitive function and related cytokines in patients with post-traumatic cognitive impairment.

Methods

Sixty patients with post-traumatic cognitive impairment hospitalized from January 2017 to October 2018 in neurosurgery department of Xuzhou Central Hospital were randomly divided into control group and treatment group, 30 cases in each group. The control group received conventional routine treatment, and the treatment group was treated with hyperbaric oxygen combined with Oxiracetam on the basis of routine treatment. The course of treatment is 3 weeks. The concentration of angiopoietin-1 (Ang-1), brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were measured, and the Chinese version of the Monterey’s cognitive-score scale (MOCA) was used to evaluate the cognitive functions before treatment and 3 weeks after treatment.

Results

Before treatment there was no significant difference in the levels of Ang-1, VEGF and BDNF between the two groups (P>0.05). After 3 weeks of treatment, the serum levels of Ang-1, VEGF and BDNF in the two groups increased. The levels of serum Ang-1, VEGF and BDNF in the treatment group were significantly higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in MOCA score between the two groups before treatment (P>0.05). After 3 weeks of treatment, the MOCA score of the treatment group was higher than that of the control group (P<0.05), and the difference was statistically significant.

Conclusion

Compared with conventional therapy, hyperbaric oxygen combined with oxiracetam can promote the secretion of Ang-1, VEGF and BDNF in patients with post-traumatic cognitive impairment, thus improving the cognitive function of patients with post-traumatic cognitive impairment.

Key words: Post-traumatic cognitive impairment, Angiopoietin-1, Vascular endothelial growth factor, Brain-derived neurotrophic factor, Hyperbaric oxygen, Oxiracetam

Yongnan Wang, Jie Yin, Changtong Tang. Effects of hyperbaric oxygen combined with Oxiracetam on cognitive function and related cytokines in patients after brain trauma[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2019, 05(06): 349-352.

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References 22

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组别	例数	男/女	年龄（岁）	受教育年限（年）	MOCA（分）	高血压病	糖尿病
治疗者	30	18/12	42.35±3.18	8.93±1.20	13.50±3.90	10	8
对照组	30	17/13	43.21±2.44	9.13±1.36	13.60±4.50	12	6
χ²/t值	?	0.069	2.002	0.474	0.478	0.287	0.373
P值	?	0.793	0.245	0.494	0.092	0.592	0.542

组别	例数	男/女	年龄（岁）	受教育年限（年）	MOCA（分）	高血压病	糖尿病
治疗者	30	18/12	42.35±3.18	8.93±1.20	13.50±3.90	10	8
对照组	30	17/13	43.21±2.44	9.13±1.36	13.60±4.50	12	6
χ²/t值	?	0.069	2.002	0.474	0.478	0.287	0.373
P值	?	0.793	0.245	0.494	0.092	0.592	0.542

组别	例数	Ang-1(pg/mL)		VEGF(nmol/mL)		BDNF(ng/mL)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	30	108.70±10.24	121.96±15.69	8.81±0.70	9.33±1.12	19.02±4.42	25.02±5.76
治疗组	30	108.40±13.29	163.65±14.03	8.70±0.66	11.11±1.46	19.68±4.49	30.07±6.03
t值	?	0.098	9.250	0.667	5.318	0.574	3.316
P值	?	0.922	0.000	0.508	0.000	0.568	0.002

组别	例数	Ang-1(pg/mL)		VEGF(nmol/mL)		BDNF(ng/mL)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	30	108.70±10.24	121.96±15.69	8.81±0.70	9.33±1.12	19.02±4.42	25.02±5.76
治疗组	30	108.40±13.29	163.65±14.03	8.70±0.66	11.11±1.46	19.68±4.49	30.07±6.03
t值	?	0.098	9.250	0.667	5.318	0.574	3.316
P值	?	0.922	0.000	0.508	0.000	0.568	0.002

组别	例数	治疗前	治疗3周后
对照组	30	13.60±4.50	14.93±3.96
治疗组	30	13.50±3.90	18.03±4.16
t值	?	0.478	2.953
P值	?	0.092	0.005

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