Meta-analysis of the relationship between drinking and cerebral hemorrhage

doi:10.3877/cma.j.issn.2095-9141.2019.05.008

Abstract

Abstract:

Objective

To study on the relationship between drinking and cerebral hemorrhage by systematic review and meta-analysis.

Methods

By using the method of systematic evaluation, online searches were conducted on English databases such as Ovid, MEDLINE, EMBASE and Chinese databases such as CNKI and Wanfang to retrieve the literature related to the risk of drinking and cerebral hemorrhage collected from the self-established database to May 2019. The quality of the literature was evaluated and the data were extracted. Meta-analysis was carried out using RevMan 5.3 and Stata12.0 software.

Results

The study included 10 articles in total. Meta-analysis showed statistically significant differences between drinking and cerebral hemorrhage (OR=0.85, 95%CI: 0.73-0.98, P=0.02). There were significant differences in the incidence of small to medium amount of alcohol drinking and cerebral hemorrhage (OR=0.69, 95%CI: 0.60-0.79, P<0.001). There was a statistically significant difference in the incidence of heavy drinking and cerebral hemorrhage (OR=1.41, 95%CI: 1.06-1.89, P=0.02). There was a statistically significant difference between female drinking and cerebral hemorrhage (OR=0.59, 95%CI: 0.48-0.72, P<0.001), there was no significant difference in male drinking and cerebral hemorrhage (OR=0.10, 95%CI: 0.89-1.14, P=0.95). In the Caucasian population, drinking is a protective factor in the occurrence of cerebral hemorrhage (OR=0.77, 95%CI: 0.61-0.97, P=0.03).

Conclusion

Drinking and cerebral hemorrhage have a correlation, a large number of alcohol drinking can significantly increase the incidence of cerebral hemorrhage.

Key words: Alcohol, Cerebral hemorrhage, Meta-analysis

Yong Zou, Yingjiang Gu, Jianwei Zhu, Tao Xu, Yu Cai, Guangwei Yang. Meta-analysis of the relationship between drinking and cerebral hemorrhage[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2019, 05(05): 289-294.

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Figures/Tables 6

References 38

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作者	研究参与人数	国家	研究类型	出血组数量	NOS评分	随访年限
Nielsen等^[20](2005)	12096	美国	队列研究	94	7	16
Leppala等^[14](1999)	26556	芬兰	队列研究	156	6	6.1
Bazzano等^[16](2007)	64338	中国	队列研究	326	6	10
Ikehara等^[11](2013)	47100	日本	队列研究	709	7	19
Costa等^[13](2018)	6328	意大利	病例对照研究	3173	7	12
Rist等^[18](2010)	21860	美国	队列研究	156	7	21.6
Jones等^[17](2015)	12433	美国	队列研究	81	7	22.6
Jimenez等^[19](2012)	114928	美国	队列研究	439	7	4
Sankai等^[15](2000)	12372	日本	队列研究	71	7	9.4
Lu等^[12](2008)	45449	瑞典	队列研究	47	7	11

作者	研究参与人数	国家	研究类型	出血组数量	NOS评分	随访年限
Nielsen等^[20](2005)	12096	美国	队列研究	94	7	16
Leppala等^[14](1999)	26556	芬兰	队列研究	156	6	6.1
Bazzano等^[16](2007)	64338	中国	队列研究	326	6	10
Ikehara等^[11](2013)	47100	日本	队列研究	709	7	19
Costa等^[13](2018)	6328	意大利	病例对照研究	3173	7	12
Rist等^[18](2010)	21860	美国	队列研究	156	7	21.6
Jones等^[17](2015)	12433	美国	队列研究	81	7	22.6
Jimenez等^[19](2012)	114928	美国	队列研究	439	7	4
Sankai等^[15](2000)	12372	日本	队列研究	71	7	9.4
Lu等^[12](2008)	45449	瑞典	队列研究	47	7	11

组别	饮酒人群（出血人数/未出血人数）	无饮酒人群（出血人数/未出血人数）	OR值	95%CI	P值
亚洲人群	672/396 886	1 964/1 031 683	0.96	0.88~1.05	0.38
高加索人群	1 089/320 497	738/128 135	0.77	0.61~0.97	0.03

组别	饮酒人群（出血人数/未出血人数）	无饮酒人群（出血人数/未出血人数）	OR值	95%CI	P值
亚洲人群	672/396 886	1 964/1 031 683	0.96	0.88~1.05	0.38
高加索人群	1 089/320 497	738/128 135	0.77	0.61~0.97	0.03

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