Application of thromboelastography in detection of coagulation disorder in patients with traumatic brain injury

doi:10.3877/cma.j.issn.2095-9141.2018.02.002

Abstract

Abstract:

Objective

Investigated the feasibility of thrombelastogram (TEG) in detection coagulation disorder in patients with traumatic brain injury (TBI).

Methods

According to GCS scores, 78 cases gathered in Department of Neurosurgery, the Shanxi Academy of Medical Sciences, were divide into two groups: heavy group (GCS≤8 scores), 38 cases: light group (GCS>8 scores) 22 cases, and 16 healthy persons were selected as the control group. Comparing the difference of coagulation system functional changes performed within 24 h after injury in the three groups and analyzing the correlation between TEG and traditional coagulation.

Results

In each group, the differences of all indicators in TEG and traditional coagulation were statistically significant (P<0.05), but the differences of APTT and PLT were not statistically significant (P>0.05). And the correlation between the results reported by two methods existed in a certain degree. R value was positively correlated with PT and APTT, fibrinogen was positively correlated with α angle, but negatively correlated with K value, MA value was positively correlated with platelet count.

Conclusion

Coagulation disorder of patients with severe TBI appears more severe than that of those with mild one. Combined use of TEG and traditional coagulation can evaluate comprehensively the early coagulation status of patients with TBI.

Key words: Brain injury, Thrombelastography, Coagulation disorders

Xiaocong Wei, Haibo Tong. Application of thromboelastography in detection of coagulation disorder in patients with traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2018, 04(02): 68-72.

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References 17

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组别	PT(s)	APTT(s)	Fib(g/L)	PLT(×10⁹/L)
对照组	11.69±1.08	28.05±4.91	3.30±0.52	218.67±74.77
轻型组	12.64±0.92^a	22.70±2.50	2.61±1.23^a	194.87±72.03^a
重型组	13.63±1.95^ab	29.05±5.35^ab	2.14±1.20^ab	190.46±71.56^a
F值	18.363	0.860	11.891	1.411
Ρ值	<0.001	0.375	0.001	0.239

组别	PT(s)	APTT(s)	Fib(g/L)	PLT(×10⁹/L)
对照组	11.69±1.08	28.05±4.91	3.30±0.52	218.67±74.77
轻型组	12.64±0.92^a	22.70±2.50	2.61±1.23^a	194.87±72.03^a
重型组	13.63±1.95^ab	29.05±5.35^ab	2.14±1.20^ab	190.46±71.56^a
F值	18.363	0.860	11.891	1.411
Ρ值	<0.001	0.375	0.001	0.239

凝血指标	R值(min)	K值(min)	α角（°）	MA值(mm)
对照组	5.35±1.06	1.65±0.37	67.22±4.04	63.71±6.73
轻型组	4.92±0.69^a	1.85±0.37	65.20±3.97^a	59.11±3.94^a
重型组	4.01±1.75^ab	3.44±3.15^ab	57.02±16.44^ab	56.01±13.55^ab
F值	12.016	8.591	9.831	6.290
Ρ值	0.001	0.004	0.002	0.014

凝血指标	R值(min)	K值(min)	α角（°）	MA值(mm)
对照组	5.35±1.06	1.65±0.37	67.22±4.04	63.71±6.73
轻型组	4.92±0.69^a	1.85±0.37	65.20±3.97^a	59.11±3.94^a
重型组	4.01±1.75^ab	3.44±3.15^ab	57.02±16.44^ab	56.01±13.55^ab
F值	12.016	8.591	9.831	6.290
Ρ值	0.001	0.004	0.002	0.014

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