Traumatic brain injury is a familiar injury, which can exist solely and also can combined with other organs, the disease is complex and changeable, often shows different degrees of irritability, resulting in brain oxygen consumption increase, intracranial pressure increased and other adverse consequences. Therefore, reasonable, scientific analgesic and sedative treatment is particularly important to relieve pain, anxiety and restlessness, reduce stress response and its damage to the body, facilitate diagnosis, care and treatment operations, and reduce complications, especially for severe patients. The pathological physiology, commonly used sedative, analgesic drugs, and the new progress of analgesic and sedative therapy are sum up in this paper.