Acute carbon monoxide poisoning is a common disease in the north of China, and the mortality rate and disability rate are very high. Acute carbon monoxide poisoning can lead to multiple organ damage in cardiovascular system and central nervous system damage in patients. Although most patients can be cured by clinical comprehensive effective treatment, but severe carbon monoxide poisoning patients prone to delayed encephalopathy after the false, its incidence is about 10%-30%. The pathogenisis is not elucidated well, but comprehensive risk factors, early prediction and proper diagnosis and treatment of delayed encephalopathy is a difficult problem to be solved in clinical work. The pathogenesis, risk factors, diagnosis and treatment of delayed encephalopathy after acute carbon monoxide poisoning were described in this paper.