CEACAM1 in the regulation of tumor immunity

doi:10.3877/cma.j.issn.2095-9141.2016.01.011

Abstract

Abstract:

Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) is a kind of Ig-like membrane protein, which belongs to the immunoglobulin superfamily and can be widely detected on endothelia, epithelia, granulocytes, lymphocytes and tumor cells. Over the years, with the rapid development of tumor immunology, it is now recognized that CEACAM1 plays an important role in multiple malignant tumors, includes non-small cell lung cancer, melanoma, colorectal cancer and pancreatic cancer. This protein can mediate anti-tumor immune ability of the body and assist the immune escape of the tumors. Thus, we need to get a full understand of the functions of CEACAM1 in immunology, to reveal the mechanism of its role and to explore its possibility as a target of tumor immunotherapy.

Key words: CEACAM1, Tumor immunology

Yazhou Wang, Jinhu Li, Wang Miao, Yimin Fan. CEACAM1 in the regulation of tumor immunity[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(01): 41-44.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsjcswkdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9141.2016.01.011

https://zhsjcswkdzzz.cma-cmc.com.cn/EN/Y2016/V02/I01/41

References 37

[1]	Beauchemin N,Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis[J]. Cancer and Metastasis Reviews, 2013, 32(3-4): 643-671.
[2]	Dupuis ML,Fiori V,Soriani A, et al. The Human Antibody Fragment DIATHIS1 Specific for CEACAM1 Enhances Natural Killer Cell Cytotoxicity Against Melanoma Cell Lines In Vitro[J]. J immunother, 2015, 38(9): 357-370.
[3]	Ling Y,Wang J,Wang L, et al. Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseases[J]. Cancer and Metastasis Rev, 2015, 34(2): 347-357.
[4]	Zippel D,Barlev H,Ortenberg R, et al. A longitudinal study of CEACAM1 expression in melanoma disease progression[J]. Oncol Rep, 2015, 33(3): 1314-1318.
[5]	Lu R,Kujawski M,Pan H, et al. Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1[J]. Cancer Res, 2012, 72(9): 2239-2250.
[6]	Gebauer F,Wicklein D,Horst J, et al. Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAM) 1, 5 and 6 as Biomarkers in Pancreatic Cancer[J]. Plos One, 2014, 9(11): e113023.
[7]	Duxbury MS. CEACAM1 Cytoplastic Expression Is Closely Related to Tumor Angiogenesis and Poorer Relapse-free Survival After Curative Resection of Hepatocellular Carcinoma[J]. World J Surg, 2011, 35(10): 2266-2267.
[8]	Berardi R,Morgese F,Onofri A, et al. Role of maspin in cancer[J]. Clin Transl Med, 2013, 2(1): 8.
[9]	Chen CJ,Kirshner J,Sherman MA, et al. Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation[J]. J Biol Chem, 2007, 282(8): 5749-5760.
[10]	Gaur S,Shively JE,Yen Y, et al. Altered splicing of CEACAM1 in breast cancer: identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms[J]. Mol Cancer, 2008, 7(5): 46.
[11]	Müller MM,Klaile E,Vorontsova O, et al. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src[J]. J cell Biol, 2009, 187(4): 569-581.
[12]	Morales VM,Christ A,Watt SM, et al. Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a)[J]. J Immunol, 1999, 163(3): 1363-1370.
[13]	Boulton IC,Gray-Owen SD. Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4⁺ T lymphocytes[J]. Nat immunol, 2002, 3(3): 229-236.
[14]	Markel G,Mussaffi H,Ling KL, et al. The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients[J]. Blood, 2004, 103(5): 1770-1778.
[15]	Markel G,Seidman R,Stern N, et al. Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions[J]. J Immunol, 2006, 177(9): 6062-6071.
[16]	Chen L,Chen Z,Baker K, et al. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction[J]. Immunity, 2012, 37(5): 930-946.
[17]	Chen D,Iijima H,Nagaishi T, et al. Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function[J]. J Immunol, 2004, 172(6): 3535-3543.
[18]	Chen Z,Chen L,Qiao SW, et al. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70[J]. J Immunol, 2008, 180(9): 6085-6093.
[19]	Nagaishi T,Pao L,Lin SH, et al. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms[J]. Immunity, 2006, 25(5): 769-781.
[20]	Ling Y,Wang J,Wang L, et al. Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseases[J]. Cancer and Metastasis Rev, 2015, 34(2): 347-357.
[21]	Huang YH,Zhu C,Kondo Y, et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion[J]. Nature, 2015, 517(7534): 386-390.
[22]	Markel G,Ortenberg R,Seidman R, et al. Systemic dysregulation of CEACAM1 in melanoma patients[J]. Cancer immunol immunother, 2010, 59(2): 215-230.
[23]	Ullrich N,Heinemann A,Nilewski E, et al. CEACAM1-3S drives melanoma cells into NK cell-mediated cytolysis and enhances patient survival[J]. Cancer Res, 2015, 75(9): 1897-1907.
[24]	Kammerer R,Riesenberg R,Weiler C, et al. The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma[J]. J pathol, 2004, 204(3): 258-267.
[25]	Hosomi S,Chen Z,Baker K, et al. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling[J]. Eur J Immunol, 2013, 43(9): 2473-2483.
[26]	Ullrich N,Heinemann A,Nilewski E, et al. CEACAM1-3S drives melanoma cells into NK cell-mediated cytolysis and enhances patient survival[J]. Cancer Res, 2015, 75(9): 1897-1907.
[27]	Satoh Y,Hayashi T,Takahashi T, et al. Expression of CD66a in multiple myeloma[J]. J Clin Lab Anal, 2002, 16(2): 79-85.
[28]	Skubitz KM,Ducker TP,Goueli SA. CD66 monoclonal antibodies recognize a phosphotyrosine-containing protein bearing a carcinoembryonic antigen cross-reacting antigen on the surface of human neutrophils[J]. J Immunol, 1992, 148(3): 852-860.
[29]	Botling J,Oberg F,Nilsson K. CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation[J]. Leukemia, 1995, 9(12): 2034-2041.
[30]	Pan H,Shively JE. Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor[J]. Immunity, 2010, 33(4): 620-631.
[31]	Huang J,Ledford KJ,Pitkin WB, et al. Targeted Deletion of Murine CEACAM 1 Activates PI3K-Akt Signaling and Contributes to the Expression of (Pro) Renin Receptor via CREB Family and NF-κB Transcription Factors[J]. Hypertension, 2013, 62(2): 317-323.
[32]	Nonaka M,Ma BY,Murai R, et al. Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells[J]. J Immunol, 2008, 180(5): 3347-3356.
[33]	Ortenberg R,Sapir Y,Raz L, et al. Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions[J]. Mol Cancer Ther, 2012, 11(6): 1300-1310.
[34]	Sivan S,Ohad H,Rona O, et al. Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms[J]. Clin Dev Immunol, 2012, 2012(4):399-408.
[35]	Inhibiting CTLA-4 and PD-1 boosts response[J]. Cancer discovery, 2013, 3(7): 710-711.
[36]	Liu J,Di G,Wu CT, et al. Development and evaluation of a novel anti-colorectal cancer monoclonal antibody, WL5[J]. Biochem Biophys Res Commun, 2013, 432(2): 370-377.
[37]	Zheng C,Feng J,Lu D, et al. A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity[J]. PloS one, 2011, 6(6): e21146.

Please choose a citation manager

Content to export