Carcinoembryonic antigenrelated cell adhesion molecule 1 and tumor

doi:10.3877/cma.j.issn.2095-9141.2015.05.012

Abstract

Abstract:

Carcinoembryonic antigenrelated cell adhesion molecule 1 (CEACAM1) is one of members of the carcinoembryonic antigen superfamily, and it is closely related with angiogenesis and lymphangion genesis of tumor, tumor cell proliferation, apoptosis, and other biological processes; in addition CEACAM1 also could be used as a biological marker of diagnosis and prognosis of multiple malignant tumor; recently, researches has found that CEACAM1 could negatively regulate immunity to suppress the anti-tumor immunocompetence, lead to tumor escapes immune surveillance and immune killing. This review summarizes the function of CEACAM1 in tumor progress.

Key words: CEACAM1, Tumor, Angiogenesis, Immunotherapy

Guotao Zhuang, Jinhu Li, Yimin Fan. Carcinoembryonic antigenrelated cell adhesion molecule 1 and tumor[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2015, 01(05): 46-49.

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