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中华神经创伤外科电子杂志 ›› 2026, Vol. 12 ›› Issue (02) : 113 -117. doi: 10.3877/cma.j.issn.2095-9141.2026.02.008

综述

胶质淋巴系统在创伤性颅脑损伤病理进程中的研究进展与挑战
王麒浩, 李文臣, 陈勃, 王海峰()   
  1. 130022 长春,吉林大学第二医院神经外科
  • 收稿日期:2025-06-20 出版日期:2026-04-15
  • 通信作者: 王海峰

Research progress and challenges of the glymphatic system in the pathological process of traumatic brain injury

Qihao Wang, Wenchen Li, Bo Chen, Haifeng Wang()   

  1. Department of Neurosurgery, The Second Hospital of Jilin University, Changchun 130022, China
  • Received:2025-06-20 Published:2026-04-15
  • Corresponding author: Haifeng Wang
  • Supported by:
    National Natural Science Foundation of China(82372505)
引用本文:

王麒浩, 李文臣, 陈勃, 王海峰. 胶质淋巴系统在创伤性颅脑损伤病理进程中的研究进展与挑战[J/OL]. 中华神经创伤外科电子杂志, 2026, 12(02): 113-117.

Qihao Wang, Wenchen Li, Bo Chen, Haifeng Wang. Research progress and challenges of the glymphatic system in the pathological process of traumatic brain injury[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2026, 12(02): 113-117.

胶质淋巴系统(GS)作为脑内重要的废物清除通路,近年来在创伤性颅脑损伤(TBI)中的研究日益增多。TBI后GS功能受损,可导致脑水肿、炎症反应及神经退行性病变的发生。近年研究虽已初步揭示了GS在TBI病理进程中的重要性,但目前对水通道蛋白-4极性调控、硬脑膜淋巴引流等具体作用机制的理解仍不充分,且缺乏标准化的多模态影像学定量评估方法。本文通过系统梳理GS的解剖生理基础,深入探讨TBI后脑水肿与睡眠障碍加剧GS功能障碍的病理机制,并重点总结当前的无创评估技术及靶向调节GS的新兴干预策略,旨在为TBI继发性损伤的临床诊疗与未来神经保护研究提供参考。

The glymphatic system (GS), a key brain waste clearance pathway, has seen growing research interest in traumatic brain injury (TBI) in recent years. Post-TBI GS impairment triggers cerebral edema, inflammatory responses, and neurodegenerative lesions. Although recent studies have revealed its importance in the pathological process of TBI, there are still problems such as an insufficient understanding of specific action mechanisms, including aquaporin-4 polarization regulation and dural lymphatic drainage, as well as the lack of standardized, multimodal neuroimaging quantitative evaluation methods. This article systematically reviews the anatomical and physiological basis of GS, deeply explores the pathological mechanisms by which post-TBI cerebral edema and sleep disorders exacerbate GS dysfunction, and highlights current non-invasive evaluation technologies and emerging targeted interventions. This review aims to provide a comprehensive reference for the clinical diagnosis and treatment of secondary TBI injury and future targeted neuroprotective research.

图1 胶质淋巴系统示意图[6]CSF:脑脊液;ISF:间质液
Fig.1 Schematic diagram of the glymphatic system[6]
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