切换至 "中华医学电子期刊资源库"
高级检索
中华神经创伤外科电子杂志

中华神经创伤外科电子杂志 ›› 2026, Vol. 12 ›› Issue (01) : 15 -23. doi: 10.3877/cma.j.issn.2095-9141.2026.01.003

临床研究

脑出血患者去骨瓣减压术后总胆红素与神经功能恢复的相关性研究
董广佩, 陶俊, 沈斌, 陈浩东, 方九强, 翟雨†()   
  1. 211500　南京市六合区人民医院神经外科
  • 收稿日期:2025-03-12 出版日期:2026-02-15
  • 通信作者: 翟雨

Study on the correlation between total bilirubin and neurological function recovery in patients with intracerebral hemorrhage after decompressive craniectomy

Guangpei Dong, Jun Tao, Bin Shen, Haodong Chen, Jiuqiang Fang, Yu Zhai†()   

  1. Department of Neurosurgery, Nanjing Luhe People's Hospital, Nanjing 211500, China
  • Received:2025-03-12 Published:2026-02-15
  • Corresponding author: Yu Zhai
全文 ( ) 下载PDF ( ) 导出引用
引用本文：

董广佩, 陶俊, 沈斌, 陈浩东, 方九强, 翟雨. 脑出血患者去骨瓣减压术后总胆红素与神经功能恢复的相关性研究[J/OL]. 中华神经创伤外科电子杂志, 2026, 12(01): 15-23.

Guangpei Dong, Jun Tao, Bin Shen, Haodong Chen, Jiuqiang Fang, Yu Zhai. Study on the correlation between total bilirubin and neurological function recovery in patients with intracerebral hemorrhage after decompressive craniectomy[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2026, 12(01): 15-23.

目的

研究脑出血（ICH）患者去骨瓣减压术（DC）后总胆红素（TBil）与神经功能恢复的关系。

方法

选取南京市六合区人民医院神经外科自2020年1月至2024年1月行DC治疗的120例ICH患者为研究对象，根据术后神经功能的恢复效果将患者分为恢复良好组（n=74）和恢复不良组（n=46）。对比2组患者的临床资料、血清学指标、血管内皮功能指标。采用重复测量方差分析评估2组患者的血管内皮功能指标及TBil的时间效应、组间效应及交互效应。采用多因素Logistic回归分析筛选ICH患者术后神经功能恢复不良的危险因素，采用局部加权回归（Lowess）分析TBil水平与血管内皮功能的相关性，建立限制性立方样条（RCS）模型分析TBil与ICH患者术后神经功能恢复不良的剂量-反应关系，采用Bootstrap法检验TBil水平对血管内皮功能与神经功能恢复不良的中介效应。

结果

2组患者的年龄、GCS评分、吸烟史、糖尿病、高血压、术前出血量、ICU住院时长、载脂蛋白B（ApoB）、载脂蛋白B/载脂蛋白A1（ApoB/ApoA1）和C反应蛋白（CRP），以及术前、术后7 d及术后14 d的一氧化氮（NO）、内皮素-1（ET-1）、降钙素基因相关肽（CGRP）、血管内皮生长因子（VEGF）、TBil水平及日常生活活动能力（ADL）评分比较，差异均具有统计学意义（P<0.05）。重复测量方差分析显示，2组患者NO、ET-1、CGRP、VEGF、TBil的时间效应、组间效应和交互效应差异均有统计学意义（P<0.05）。多因素Logistic回归分析显示，吸烟、糖尿病、高血压、年龄（>50岁）、GCS评分（≤9分）、术前出血量（>44.8 mL）、ICU住院时长（>8 d）、ADL评分（≤65分）、ApoB（>1.37 g/L）、ApoB/ApoA1（>0.99）、CRP（>12.30 mg/L）、NO（≤12.35 μmol/L）、ET-1（>47.30 ng/L）、CGRP（≤52.05 ng/L）、VEGF（>233.85 μg/L）和TBil（>13.64 μmol/L）是ICH患者术后神经功能恢复不良的独立危险因素（P<0.05）。Lowess分析显示，TBil与NO、CGRP呈负相关，与ET-1、VEGF呈正相关（均P<0.05）。RCS模型分析显示，TBil与术后神经功能恢复不良风险的关联强度呈非线性剂量-反应关系（Pfor non linear<0.05）。中介效应模型分析显示，TBil在NO、ET-1、CGRP、VEGF和神经功能恢复不良间发挥部分中介效应。

结论

ICH患者DC后TBil与神经功能恢复指标存在明显线性相关性，TBil>13.64 μmol/L是神经功能恢复不良的独立危险因素，术后TBil水平越低，神经功能恢复效果越好。

关键词: 脑出血, 去骨瓣减压术, 总胆红素, 神经功能
Objective

To explore the correlation between total bilirubin (TBil) and neurological function recovery in patients with intracerebral hemorrhage (ICH) after decompressive craniectomy (DC).

Methods

A total of 120 patients with ICH who underwent DC in Neurosurgery Department of Nanjing Luhe People's Hospital from January 2020 to January 2024 were selected as the research subjects. The patients were divided into a good recovery group (n=74) and a poor recovery group (n=46) according to the effect of nerve function recovery. The clinical data, serological indicators, vascular endothelial function indicators and TBil of two groups of patients were compared. The time effect, intergroup effect and interaction effect of vascular endothelial function indicators and TBil were analyzed by repeated measurement of variance. The multivariate Logistic was used to analyze the factors of poor recovery of neurological function. The locally weighted regression (Lowess) was used to analyze the correlation between TBil level and vascular endothelial function indicators. The restricted cubic spline (RCS) model was established to analyze the dose-response relationship between TBil and poor recovery of neurological function in patients with ICH. The Bootstrap method was used to examine the mediating effect of TBil level on vascular endothelial function and poor recovery of neurological function.

Results

The age, GCS score, smoking, diabetes, hypertension, preoperative blood loss, length of ICU stay, apolipoprotein B (ApoB), apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) and C-reactive protein (CRP) in the two groups were statistically significant (P<0.05); and the levels of nitric oxide (NO), endothelin-1 (ET-1), calcitonin gene related peptide (CGRP), vascular endothelial growth factor (VEGF), TBil and activity of daily living (ADL) score in the two groups before surgery and at 7 and 14 d after surgery were statistically significant (P<0.05). The repeated measurement of variance showed that the time effect, intergroup effect and interaction effect of NO, ET-1, CGRP, VEGF and TBil in the two groups were statistically significant (P<0.05). The multivariate Logistic analysis showed that smoking, diabetes, hypertension, age (>50 years), GCS score (≤9 scores), preoperative blood loss (>44.8 mL), length of ICU stay (>8 d), ADL score (≤65 scores), ApoB (>1.37 g/L), ApoB/ApoA1 (>0.99), CRP (>12.30 mg/L), NO (≤12.35 μmol/L), ET-1 (>47.30 ng/L), CGRP (≤52.05 ng/L), VEGF (>233.85 μg/L) and TBil (>13.64 μmol/L) were risk factors for poor neurological recovery in patients with ICH (P<0.05). The Lowess analysis showed that TBil was negatively correlated with NO and CGRP, and positively correlated with ET-1 and VEGF, and all the correlations were statistically significant (P<0.05). The RCS model analysis showed that TBil was correlated with the risk of poor postoperative neurological function recovery in a nonlinear dose-response relationship (P for non linear<0.05). The mediation effect model showed that TBil played a partial mediating effect between NO, ET-1, CGRP, VEGF and poor neurological function recovery.

Conclusions

After DC, there is a significant linear correlation between TBil and function recovery index in patients with ICH. TBil (>13.64 μmol/L) is an independent risk factor for poor neurological recovery, and the lower the postoperative TBil level, the better the neurological function recovery effect.

Key words: Intracerebral hemorrhage, Decompressive craniectomy, Total bilirubin, Neurological function
表1 2组ICH患者临床资料比较
Tab.1 Comparison of clinical data of ICH patients in two groups
项目 恢复良好组（n=74） 恢复不良组（n=46） χ2/t/Z值 P值
性别[例（%）]     0.167 0.683
男 39（52.70） 26（56.52）    
女 35（47.30） 20（43.48）    
年龄（岁，±s） 47.05±8.47 53.70±7.79 4.310 <0.001
BMI（kg/m2，±s） 22.47±2.39 22.72±1.85 0.605 0.546
GCS评分（分，±s） 9.39±1.87 7.28±1.49 6.477 <0.001
吸烟史[例（%）] 25（33.78） 24（52.17） 3.971 0.046
饮酒史[例（%）] 26（35.14） 18（39.13） 0.195 0.659
糖尿病[例（%）] 10（13.51） 15（32.61） 6.271 0.012
冠心病[例（%）] 12（16.22） 9（19.57） 0.220 0.639
高血压[例（%）] 9（12.16） 13（28.26） 4.910 0.027
受伤距入院时间（h，±s） 2.24±0.74 2.42±0.81 1.249 0.214
术前出血量（mL，±s） 43.05±6.44 47.79±7.27 3.730 <0.001
ICU住院时长（d，±s） 7.53±1.77 9.87±2.07 3.776 <0.001
ADL评分（分，±s） 71.18±4.56 54.46±6.08 17.150 <0.001
WBC（×109/L，±s） 10.56±3.26 11.48±3.49 1.463 0.146
NEU（×109/L，±s） 5.17±1.62 5.51±1.84 1.061 0.291
LYM[×109/L，M（P25，P75）] 1.97（1.16，2.66） 1.85（1.27，2.65） 0.221 0.825
PLT（×109/L，±s） 209.56±42.87 196.94±41.64 1.585 0.166
Hb（g/L，±s） 140.31±17.68 134.69±16.53 1.735 0.085
TC（mmol/L，±s） 4.93±1.02 4.58±0.93 1.889 0.061
TG（mmol/L，±s） 1.66±0.53 1.74±0.56 0.787 0.433
ApoB（g/L，±s） 1.31±0.35 1.47±0.36 2.408 0.018
ApoA1（g/L，±s） 1.38±0.38 1.32±0.40 0.824 0.412
ApoB/ApoA1（±s） 0.99±0.27 1.20±0.39 3.483 0.001
CRP（mg/L，±s） 11.24±2.73 13.96±2.47 5.500 <0.001
表2 2组ICH患者TBil水平比较（μmol/L，±s）
Tab.2 Comparison of TBil levels in two groups of ICH patients (μmol/L, Mean±SD)
组别 例数 术前 术后7 d 术后14 d F值 P值
恢复良好组 74 20.39±3.06 17.78±3.12a 12.89±2.17ab 17.371 <0.001
恢复不良组 46 22.35±3.41 20.36±3.20a 15.47±2.67ab 59.653 <0.001
t值   3.264 4.361 5.086    
P值   0.001 <0.001 <0.001    
表3 2组ICH患者血管内皮功能指标比较（±s）
Tab.3 Comparison of vascular endothelial function indicators in two groups of ICH patients (Mean±SD)
组别 例数 NO（μmol/L） ET-1（ng/L）
术前 术后7 d 术后14 d F值 P值 术前 术后7 d 术后14 d F值 P值
恢复良好组 74 7.41±0.54 10.71±0.83a 12.74±0.65ab 1145.070 <0.001 87.59±8.84 74.63±6.19a 44.30±5.75ab 732.926 <0.001
恢复不良组 46 7.16±0.61 9.56±0.91a 10.98±0.76ab 289.393 <0.001 91.22±9.25 83.31±7.82a 55.25±6.02ab 269.502 <0.001
t值   2.345 7.111 13.507     2.149 6.742 9.962    
P值   0.021 <0.001 <0.001     0.034 <0.001 <0.001    
组别 例数 CGRP（ng/L） VEGF（μg/L）
术前 术后7 d 术后14 d F值 P值 术前 术后7 d 术后14 d F值 P值
恢复良好组 74 35.88±5.87 47.45±5.26a 55.68±6.11ab 220.846 <0.001 310.44±18.99 270.54±16.64a 224.31±14.56ab 485.532 <0.001
恢复不良组 46 33.14±5.36 42.61±5.08a 46.44±5.83ab 73.070 <0.001 317.62±19.12 293.57±17.86a 257.78±16.78ab 129.511 <0.001
t值   2.569 4.965 8.196     2.008 7.145 11.542    
P值   0.011 <0.001 <0.001     0.047 <0.001 <0.001    
表4 血管内皮功能指标与TBil水平的重复测量方差分析
Tab.4 Repeated measures analysis of variance for vascular endothelial function indicators and TBil
指标 时间效应 组间效应 交互效应
F值 P值 F值 P值 F值 P值
NO 456.980 <0.001 444.370 <0.001 210.214 <0.001
ET-1 288.851 <0.001 312.930 <0.001 137.765 <0.001
CGRP 274.999 <0.001 317.831 <0.001 83.095 <0.001
VEGF 165.816 <0.001 93.959 <0.001 49.092 <0.001
TBil 316.518 <0.001 336.597 <0.001 98.048 <0.001
表5 ICH患者去骨瓣减压术后神经功能恢复不良影响因素的多因素Logistic回归分析
Tab.5 Multivariate Logistic regression analysis of factors affecting poor neurological recovery after decompressive craniectomy in ICH patients
项目 偏回归系数 标准误 Wald χ2值 OR值 95%CI值 P值
临床模型一            
吸烟 0.377 0.169 5.001 1.458 1.048~2.030 0.027
糖尿病 0.456 0.160 8.118 1.578 1.153~2.159 0.005
高血压 0.402 0.177 5.162 1.495 1.057~2.115 0.025
年龄（>50岁） 0.578 0.269 4.606 1.783 1.051~3.023 0.034
GCS评分（≤9分） 0.646 0.263 6.043 1.908 1.140~3.193 0.015
术前出血量（>44.8 mL） 0.662 0.304 4.736 1.939 1.068~3.519 0.031
ICU住院时长（>8 d） 0.508 0.243 4.373 1.662 1.032~2.675 0.039
ADL评分（≤65分） 0.586 0.278 4.449 1.798 1.042~3.101 0.037
ApoB（>1.37 g/L） 0.576 0.252 5.233 1.778 1.086~2.912 0.024
ApoB/ApoA1（>0.99） 0.600 0.260 5.339 1.821 1.095~3.029 0.023
CRP（>12.30 mg/L） 0.669 0.274 5.963 1.952 1.141~3.339 0.016
临床模型二            
吸烟 0.385 0.180 4.578 1.469 1.033~2.090 0.034
糖尿病 0.463 0.171 7.332 1.588 1.136~2.221 0.008
高血压 0.410 0.187 4.782 1.506 1.043~2.175 0.031
年龄（>50岁） 0.585 0.281 4.340 1.794 1.035~3.111 0.039
GCS评分（≤9分） 0.652 0.273 5.691 1.919 1.123~3.279 0.019
术前出血量（>44.8 mL） 0.668 0.315 4.490 1.950 1.051~3.618 0.036
ICU住院时长（>8 d） 0.515 0.254 4.117 1.673 1.018~2.751 0.045
ADL评分（≤65分） 0.593 0.290 4.184 1.809 1.025~3.193 0.043
ApoB（>1.37 g/L） 0.582 0.263 4.889 1.789 1.068~2.996 0.029
ApoB/ApoA1（>0.99） 0.606 0.270 5.047 1.833 1.080~3.109 0.026
CRP（>12.30 mg/L） 0.674 0.286 5.565 1.963 1.121~3.437 0.020
NO（≤12.35 μmol/L） 0.606 0.231 6.878 1.833 1.165~2.882 0.010
ET-1（>47.30 ng/L） 0.536 0.221 5.871 1.709 1.108~2.638 0.017
CGRP（≤52.05 ng/L） 0.611 0.235 6.751 1.842 1.162~2.922 0.011
VEGF（>233.85 μg/L） 0.572 0.269 4.519 1.771 1.046~3.001 0.036
TBil（>13.64 μmol/L） 0.509 0.220 5.337 1.664 1.079~2.563 0.023
图1 TBil水平与血管内皮功能指标的Lowess相关性分析A：NO；B：ET-1；C：CGRP；D：VEGF；NO：一氧化氮；ET-1：内皮素-1；CGRP：降钙素基因相关肽；VEGF：血管内皮生长因子；TBil：总胆红素
Fig.1 Lowess correlation analysis between TBil level and vascular endothelial function indicators
图2 TBil水平与ICH患者术后神经功能恢复不良风险的剂量-反应关系ICH：脑出血；TBil：总胆红素
Fig.2 Dose-response relationship between TBil levels and the risk of poor postoperative neurological function recovery in ICH patients
表6 TBil水平对血管内皮功能及神经功能恢复不良的中介效应
Tab.6 Mediating effect of TBil levels on poor recovery of vascular endothelial function and neurological function
血管内皮功能 步骤 因变量 自变量 β值 SE t值 P值
NO 第1步 神经功能恢复不良 NO 0.356c 0.037 9.622 <0.001
  第2步 TBil NO 0.412a 0.041 10.049 <0.001
  第3步 神经功能恢复不良 NO 0.524c' 0.035 14.974 <0.001
      TBil 0.408b 0.043 9.488 <0.001
ET-1 第1步 神经功能恢复不良 ET-1 0.301c 0.051 5.902 <0.001
  第2步 TBil ET-1 0.374a 0.036 10.389 <0.001
  第3步 神经功能恢复不良 ET-1 0.464c' 0.045 10.321 <0.001
      TBil 0.437b 0.040 10.925 <0.001
CGRP 第1步 神经功能恢复不良 CGRP 0.311c 0.043 7.233 <0.001
  第2步 TBil CGRP 0.385a 0.033 11.667 <0.001
  第3步 神经功能恢复不良 CGRP 0.477c' 0.037 12.890 <0.001
      TBil 0.431b 0.046 9.370 <0.001
VEGF 第1步 神经功能恢复不良 VEGF 0.319c 0.034 9.382 <0.001
  第2步 TBil VEGF 0.403a 0.032 12.594 <0.001
  第3步 神经功能恢复不良 VEGF 0.475c' 0.039 12.168 <0.001
      TBil 0.386b 0.044 8.773 <0.001
[1]
Larsson SC, Chen J, Gill D, et al. Risk factors for intracerebral hemorrhage: genome-wide association study and Mendelian randomization analyses[J]. Stroke, 2024, 55(6): 1582-1591. DOI: 10.1161/strokeaha.124.046249.
[2]
Wolsink A, Cliteur MP, van Asch CJ, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage, according to age, sex, and country income level: a systematic review and meta-analysis[J]. Lancet Reg Health Eur, 2025, 49: 101180. DOI: 10.1016/j.lanepe.2024.101180.
[3]
Yang S, Liu Y, Wang S, et al. Association between high serum blood glucose lymphocyte ratio and all-cause mortality in non-traumatic cerebral hemorrhage: a retrospective analysis of the MIMIC-IV database[J]. Front Endocrinol (Lausanne), 2023, 14: 1290176. DOI: 10.3389/fendo.2023.1290176.
[4]
丁锦荣,张寒,管义祥.联合监测颅内压力参数ICP、PRx、MWA对高血压脑出血去骨瓣减压术后患者预后的预测价值[J].新疆医科大学学报, 2023, 46(11): 1457-1462. DOI: 10.3969/j.issn.1009-5551.2023.11.008.
[5]
Zhang Y, Luan H, Song P. Bilirubin metabolism and its application in disease prevention: mechanisms and research advances[J]. Inflamm Res, 2025, 74(1): 81. DOI: 10.1007/s00011-025-02049-w.
[6]
Chen J, Chen Y, Lin Y, et al. Roles of bilirubin in hemorrhagic transformation of different types and severity[J]. J Clin Med, 2023, 12(4): 1471. DOI: 10.3390/jcm12041471.
[7]
Sheng X, Du H, Tang Y. Decreased serum total bilirubin level predicts early neurological deterioration in patients with acute ischemic stroke[J]. Neuropsychiatr Dis Treat, 2021, 17: 1977-1982. DOI: 10.2147/ndt.S315330.
[8]
林振飞,陈世洁.立体定向穿刺引流术治疗基底节区脑出血的价值探究[J].中华神经创伤外科电子杂志, 2022, 8(1): 34-38. DOI: 10.3877/cma.j.issn.2095-9141.2022.01.007.
[9]
唐芷晴,苏文龙,党辉,等.恢复期脑外伤患者日常生活活动能力的预测模型研究[J].中国康复医学杂志, 2024, 39(7): 952-958. DOI: 10.3969/j.issn.1001-1242.2024.07.006.
[10]
Dasari R, Bonsack F, Sukumari-Ramesh S. Brain injury and repair after intracerebral hemorrhage: the role of microglia and brain-infiltrating macrophages[J]. Neurochem Int, 2021, 142: 104923. DOI: 10.1016/j.neuint.2020.104923.
[11]
Zhang C, Zhang S, Yin Y, et al. Clot removAl with or without decompRessive craniectomy under ICP monitoring for supratentorial IntraCerebral Hemorrhage (CARICH): a randomized controlled trial[J]. Int J Surg, 2024, 110(8): 4804-4809. DOI: 10.1097/js9.0000000000001466.
[12]
Chen Y, Chen S, Chang J, et al. Perihematomal edema after intracerebral hemorrhage: an update on pathogenesis, risk factors, and therapeutic advances[J]. Front Immunol, 2021, 12: 740632. DOI: 10.3389/fimmu.2021.740632.
[13]
Peng Q, Bi R, Chen S, et al. Predictive value of different bilirubin subtypes for clinical outcomes in patients with acute ischemic stroke receiving thrombolysis therapy[J]. CNS Neurosci Ther, 2022, 28(2): 226-236. DOI: 10.1111/cns.13759.
[14]
Wang X, Wu D, Zhong P. Serum bilirubin and ischaemic stroke: a review of literature[J]. Stroke Vasc Neurol, 2020, 5(2): 198-204. DOI: 10.1136/svn-2019-000289.
[15]
Ungvari A, Kállai A, Stankovics L, et al. Age-related alterations of cerebral autoregulation[J]. Life (Basel), 2025, 15(11): 1669. DOI: 10.3390/life15111669.
[16]
Zhou SY, Du JM, Li WJ, et al. The roles and regulatory mechanisms of cigarette smoke constituents in vascular remodeling[J]. Int Immunopharmacol, 2024, 140: 112784. DOI: 10.1016/j.intimp.2024.112784.
[17]
Hashmat A, Ya J, Kadir R, et al. Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function[J]. Tissue Barriers, 2025, 13(1): 2350821. DOI: 10.1080/21688370.2024.2350821.
[18]
Osman A, Kanaan A, Azeroual S, et al. Hypertension and cerebral small vessel disease: a review of the pathophysiology, progression, and prevention[J]. Cureus, 2025, 17(9): e92760. DOI: 10.7759/cureus.92760.
[19]
Wang S, Zhang W, Li J, et al. Nomogram based on pan-immune-inflammation value to predict short-term prognosis in spontaneous intracerebral hemorrhage[J]. Front Neurol, 2025, 16: 1606436. DOI: 10.3389/fneur.2025.1606436.
[20]
Lei C, Li C, Chen X, et al. Comparison of neurofactor changes and prognosis in elderly patients with spontaneous intracerebral hemorrhage treated with endoscopic versus conventional craniotomy surgery[J]. Ther Clin Risk Manag, 2025, 21: 1509-1519. DOI: 10.2147/tcrm.S521299.
[21]
Zhang W, Wang R, Shi F. Impact of serum apolipoproteins on the prognosis of acute ischemic stroke after thrombolysis[J]. J Stroke Cerebrovasc Dis, 2024, 33(11): 107944. DOI: 10.1016/j.jstrokecerebrovasdis.2024.107944.
[22]
Alsamani R, Limin Z, Jianwei W, et al. Predictive value of the apolipoprotein B/A1 ratio in intracerebral hemorrhage outcomes[J]. J Clin Lab Anal, 2022, 36(7): e24562. DOI: 10.1002/jcla.24562.
[23]
Bader ER, Pana TA, Barlas RS, et al. Elevated inflammatory biomarkers and poor outcomes in intracerebral hemorrhage[J]. J Neurol, 2022, 269(12): 6330-6341. DOI: 10.1007/s00415-022-11284-8.
[24]
Hao GS, Fan QL, Hu QZ, et al. Research progress on the mechanism of cerebral blood flow regulation in hypoxia environment at plateau[J]. Bioengineered, 2022, 13(3): 6353-6358. DOI: 10.1080/21655979.2021.2024950.
[25]
范真真,孙鲁琨,彭霈,等.康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP的影响[J].现代生物医学进展, 2024, 24(5): 882-886. DOI: 10.13241/j.cnki.pmb.2024.05.014.
[26]
Song Q, Liang Y, Zhang Y, et al. Effect of mild therapeutic hypothermia combined with stereotactic aspiration on patients with severe cerebral hemorrhage[J]. Mol Biotechnol, 2024, 66(10): 2804-2815. DOI: 10.1007/s12033-023-00882-0.
[27]
王晓毅,黄海林,成刚.血清Lp(a)、MBP、CGRP在预测脑出血术后早期颅内感染的效能研究[J].临床神经外科杂志, 2022, 19(5): 574-578, 582. DOI: 10.3969/j.issn.1672-7770.2022.05.021.
[28]
刘显国,李胜利,黄国祥,等.尼莫地平片治疗急性脑出血患者的临床研究分析[J].中国临床药理学杂志, 2022, 38(4): 296-299. DOI: 10.13699/j.cnki.1001-6821.2022.04.002.
[29]
郑海军,戴凯茜,娄晓辉,等.缺氧诱导因子-1α/血管内皮生长因子通路表达与高血压脑出血破入脑室患者颅内压及预后的相关性[J].中华高血压杂志, 2022, 30(3): 283-286. DOI: 10.16439/j.issn.1673-7245.2022.03.014.
[30]
Chen S, Li L, Peng C, et al. Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage[J]. Antioxid Redox Signal, 2022, 37(1-3): 115-134. DOI: 10.1089/ars.2021.0072.
[31]
邹辉,杜鑫.血清D-二聚体和间接胆红素水平在预测缺血性脑卒中溶栓后脑出血转化的临床价值[J].实用医院临床杂志, 2022, 19(6): 130-133. DOI: 10.3969/j.issn.1672-6170.2022.06.037.
[32]
Zhu M, He H, Yu D, et al. Prediction of prognosis in patients with ischemic stroke combined with type 2 diabetes mellitus based on serum total bilirubin levels[J]. Medicine (Baltimore), 2024, 103(12): e37468. DOI: 10.1097/MD.0000000000037468.
[1] 李运帷, 段晓春, 齐文涛. 重型颅脑损伤术后创伤性脑梗死的危险因素与发病机制研究进展[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(06): 398-404.
[2] 李毅, 姚略, 侯相见. 颅脑损伤去骨瓣减压术后新发出血的风险预测列线图模型构建[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(05): 307-313.
[3] 马剑波, 许浩, 陈一笑. 人脐带间充质干细胞来源外泌体对脑出血后炎症反应和神经损伤的作用机制[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(05): 280-289.
[4] 陈靓, 曾义, 高安亮, 冯杰, 李春玲, 陈隆益, 徐如祥, 何永生. NICU自发性脑出血患者急诊开颅术后医院获得性肺炎的危险因素分析[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(04): 250-255.
[5] 世界华人神经外科协会颅脑创伤专业委员会, 颅骨缺损修补术专家共识协作组. 颅骨缺损修补术专家共识（2025版）[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(04): 210-219.
[6] 方九强, 翟雨, 杨俊峰, 沈斌. 颅内血肿清除术联合去骨瓣减压术治疗创伤性颅脑损伤患者的效果分析[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(03): 160-166.
[7] 周颖, 张琳琳, 陈光强, 石广志, 周建新. 阵发性交感神经过度兴奋四例临床特征分析[J/OL]. 中华重症医学电子杂志, 2025, 11(03): 302-310.
[8] 李新宇, 梁建锋. 神经内镜治疗基底节区脑出血技术探讨[J/OL]. 中华脑科疾病与康复杂志(电子版), 2025, 15(05): 317-320.
[9] 赵金凤, 王凌毅, 姜东春. 体外冲击波刺激足三里及肩髃对糖尿病性胃轻瘫患者胃肠动力及自主神经功能的调节作用[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(05): 539-545.
[10] 王旭, 陈炳伟. 冠状动脉介入治疗后脑出血致尖顶军盔征心电图一例[J/OL]. 中华心脏与心律电子杂志, 2025, 13(03): 186-188.
[11] 卓玛, 陈玉秀, 连雨晴, 周立新, 郝渝, 季士勇, 胡亚雄, 丁志杰, 赵伟伟, 次旦卓嘎, 袁晶, 赵玉华. 久居高原地区高血压脑出血患者脑出血量与血清C反应蛋白水平的相关性[J/OL]. 中华脑血管病杂志(电子版), 2026, 20(01): 57-60.
[12] 钱海舟, 张珊珊, 殷琳玲, 吴智强, 汪露, 杨欢. 经颅多普勒超声在急性前循环大血管闭塞性脑梗死机械取栓后的应用价值[J/OL]. 中华脑血管病杂志(电子版), 2026, 20(01): 61-67.
[13] 李敏, 钟孟飞, 胡孟良, 巴莎莎. 穿支动脉粥样硬化性疾病相关卒中患者静脉溶栓后早期神经功能恶化的危险因素分析[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(04): 304-311.
[14] 闫江婷, 王静茹, 杨莹, 林莉瑶, 杨叶, 黄晓松, 曾贵荣. L-茶氨酸对大鼠脑缺血模型神经功能的影响[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(04): 324-331.
[15] 黄秋慧, 梁志坚. 人类免疫缺陷病毒感染患者并发脑出血的研究进展[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(03): 255-259.
阅读次数
全文


摘要

版权所有 中华医学会 中华医学电子音像出版社有限责任公司  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号

AI
小
编
AI小编
你好！我是《中华医学电子期刊资源库》AI小编，有什么可以帮您的吗？