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中华神经创伤外科电子杂志 ›› 2025, Vol. 11 ›› Issue (03) : 185 -191. doi: 10.3877/cma.j.issn.2095-9141.2025.03.008

综述

创伤后应激障碍的生物标志物研究进展
张泽瀚1, 费晓炜1, 吕伟豪1, 蔡敏1, 庄茁2, 王化宁1, 费舟1,†()   
  1. 1710032　西安，解放军空军军医大学西京医院神经外科
    2100084　北京，清华大学航天航空学院
  • 收稿日期:2025-01-01 出版日期:2025-06-15
  • 通信作者: 费舟

Research progress on biomarkers of post-traumatic stress disorder

Zehan Zhang1, Xiaowei Fei1, Weihao Lyu1, Min Cai1, Zhuo Zhuang2, Huaning Wang1, Zhou Fei1,†()   

  1. 1Department of Neurosurgery, Xijing Hospital, Air Force Medical University, Chinese People's Liberation Army, Xi'an 710032, China
    2School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
  • Received:2025-01-01 Published:2025-06-15
  • Corresponding author: Zhou Fei
  • Supported by:
    National Key Research and Development Program(2020-JCJQ-ZD-254-04); Major Science and Technology Research Project on Military Medicine and Aviation Medicine of the Air Force Medical University in 2023(2023JSYX04)
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张泽瀚, 费晓炜, 吕伟豪, 蔡敏, 庄茁, 王化宁, 费舟. 创伤后应激障碍的生物标志物研究进展[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(03): 185-191.

Zehan Zhang, Xiaowei Fei, Weihao Lyu, Min Cai, Zhuo Zhuang, Huaning Wang, Zhou Fei. Research progress on biomarkers of post-traumatic stress disorder[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2025, 11(03): 185-191.

创伤后应激障碍（PTSD）源于个体经历创伤性事件后所产生的精神健康障碍，常因爆炸或冲击等外部因素所触发，在军事战争中其患病率异常显著，对患者及社会造成极大危害。目前对PTSD的诊断仍缺乏客观标准，对其进行筛查和定性诊断存在困难。本文总结了最新生物标志物的研究进展，包括PTSD相关遗传易感性生物标志物、神经影像学发现的大脑结构及功能改变相关的生物标志物、外周自主神经系统功能变化及特异性外周体液生物标志物等，并探讨这些生物标志物在临床中的潜在应用，旨在为PTSD的早期识别、诊断和个性化治疗提供科学依据，推动生物标志物在临床实践中的应用。

关键词: 创伤后应激障碍, 生物标志物, 蛋白质组学, 遗传易感性, 核磁共振

Post-traumatic stress disorder (PTSD) is a mental health condition that arises following an individual's exposure to traumatic events, often triggered by external factors such as explosions or shock, particularly evident in military conflicts, where its prevalence is significantly high, causing severe repercussions for both patients and society. Currently, the diagnosis of PTSD lacks objective standards, making screening and qualitative assessment challenging. This paper summarizes the latest research progress on genetic susceptibility biomarkers related to PTSD, biomarkers associated with structural and functional changes in the brain as revealed by neuroimaging findings, alterations in peripheral autonomic nervous system function, and specific peripheral fluid biomarkers, while also exploring the potential clinical applications of these biomarkers. The aim of this review is to provide a scientific basis for the early recognition, diagnosis, and personalized treatment of PTSD, thereby promoting the application of biomarkers in clinical practice.

Key words: Post-traumatic stress disorder, Biomarkers, Proteomics, Genetic susceptibility, Magnetic resonance
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