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中华神经创伤外科电子杂志 ›› 2023, Vol. 09 ›› Issue (06) : 321 -324. doi: 10.3877/cma.j.issn.2095-9141.2023.06.001

述评

脊髓损伤的治疗新进展
郭莉丽, 高谋, 徐如祥()   
  1. 610030 成都,电子科技大学附属医院·四川省人民医院神经外科
    100700 北京,解放军总医院第一医学中心神经外科医学部
  • 收稿日期:2023-11-03 出版日期:2023-12-15
  • 通信作者: 徐如祥

Recent progress in the treatment of spinal cord injury

Lili Guo, Mou Gao, Ruxiang Xu()   

  1. Department of Neurosurgery, Affiliated Hospital of University of Electronic Science and Technology of China/Sichuan Provincial People's Hospital, Chengdu 610030, China
    Department of Neurosurgery, First Medical Center of General Military Hospital, Beijing 100700, China
  • Received:2023-11-03 Published:2023-12-15
  • Corresponding author: Ruxiang Xu
  • Supported by:
    National Natural Science Foundation of China(81671189, 81971295)
引用本文:

郭莉丽, 高谋, 徐如祥. 脊髓损伤的治疗新进展[J/OL]. 中华神经创伤外科电子杂志, 2023, 09(06): 321-324.

Lili Guo, Mou Gao, Ruxiang Xu. Recent progress in the treatment of spinal cord injury[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(06): 321-324.

脊髓损伤属于中枢神经系统的重大疾病之一,患者常遗留永久性截瘫及膀胱直肠括约肌功能障碍,终身丧失劳动及生活自理能力,给家庭及社会带来沉重压力和经济负担。近年来,神经干细胞移植治疗、神经外泌体治疗、脑机接口-神经调控治疗、3D打印定制脊髓类器官修复等新技术快速发展,为脊髓损伤患者提供了更有效、更个性化的治疗新策略和新方法。本文针对脊髓损伤的治疗新进展作一述评。

Spinal cord injury is one of the major diseases of central nervous system. The patients suffered from permanent paraplegia and bladder and rectal sphincter dysfunction, and involved with life-long loss of the ability to work and self-care. The family and society were gone through heavy pressure and economic burden. In recent years, new technologies such as neural stem cells transplantation, neuroexosome therapy, brain-computer interface-neural regulation therapy and 3D-printed customized spinal cord organoid repair have been developed rapidly. It will provide more effective and personalized treatment for spinal cord injury patients with new strategies and new methods. This article provides a review of recent progress in the treatment of spinal cord injury.

[1]
Ke H, Yang H, Zhao Y, et al. 3D gelatin microsphere scaffolds promote functional recovery after spinal cord hemisection in rats[J]. Adv Sci (Weinh), 2023, 10(3): e2204528. DOI: 10.1002/advs.202204528.
[2]
Tetzlaff W, Okon EB, Karimi-Abdolrezaee S, et al. A systematic review of cellular transplantation therapies for spinal cord injury[J]. J Neurotrauma, 2011, 28(8): 1611-1682. DOI: 10.1089/neu.2009.1177.
[3]
Fan L, Liu C, Chen X, et al. Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair[J]. ACS Appl Mater Interfaces, 2018, 10(21): 17742-17755. DOI: 10.1021/acsami.8b05293.
[4]
Karimi-Abdolrezaee S, Eftekharpour E. Stem cells and spinal cord injury repair[J]. Adv Exp Med Biol, 2012, 76053-73. DOI: 10.1007/978-1-4614-4090-1_4.
[5]
Assinck P, Duncan GJ, Hilton BJ, et al. Cell transplantation therapy for spinal cord injury[J]. Nat Neurosci, 2017, 20(5): 637-647. DOI: 10.1038/nn.4541.
[6]
Xi K, Gu Y, Tang J, et al. Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery[J]. Nat Commun, 2020, 11(1): 4504. DOI: 10.1038/s41467-020-18265-3.
[7]
Vasanthan LT, Nehrujee A, Solomon J, et al. Electrical stimulation for people with spinal cord injury[J]. Cochrane Database Syst Rev, 2019, 2019(11): CD013481. DOI: 10.1002/14651858.CD013481
[8]
Mak JN, Wolpaw JR. Clinical applications of brain-computer interfaces: current state and future prospects[J]. IEEE Rev Biomed Eng, 2009, 2: 187-199. DOI: 10.1109/rbme.2009.2035356.
[9]
Sui Y, Yu H, Zhang C, et al. Deep brain-machine interfaces: Sensing and modulating the human deep brain[J]. Natl Sci Rev, 2022, 9(10): nwac212. DOI: 10.1093/nsr/nwac212.
[10]
O'Doherty JE, Lebedev MA, Ifft PJ, et al. Active tactile exploration using a brain-machine-brain interface[J]. Nature, 2011, 479(7372): 228-231. DOI: 10.1038/nature10489.
[11]
Griffin JM, Bradke F. Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem[J]. EMBO Mol Med, 2020, 12(3): e11505. DOI: 10.15252/emmm.201911505.
[12]
Han Q, Jin W, Xiao Z, et al. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody[J]. Biomaterials, 2010, 31(35): 9212-9220. DOI: 10.1016/j.biomaterials.2010.08.040.
[13]
Liu W, Xu B, Zhao S, et al. Spinal cord tissue engineering via covalent interaction between biomaterials and cells[J]. Sci Adv, 2023, 9(6): eade8829. DOI: 10.1126/sciadv.ade8829.
[14]
Phang I, Zoumprouli A, Papadopoulos MC, et al. Microdialysis to optimize cord perfusion and drug delivery in spinal cord injury[J]. Ann Neurol, 2016, 80(4): 522-531. DOI: 10.1002/ana.24750.
[15]
Ren H, Chen X, Tian M, et al. Regulation of inflammatory cytokines for spinal cord injury repair through local delivery of therapeutic agents[J]. Adv Sci (Weinh), 2018, 5(11): 1800529. DOI: 10.1002/advs.201800529.
[16]
Chen S, Li R, Li X, et al. Electrospinning: an enabling nanotechnology platform for drug delivery and regenerative medicine[J]. Adv Drug Deliv Rev, 2018, 132: 188-213. DOI: 10.1016/j.addr.2018.05.001.
[17]
Bonizzato M, James ND, Pidpruzhnykova G, et al. Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury[J]. Nat Commun, 2021, 12(1): 1925. DOI: 10.1038/s41467-021-22137-9.
[18]
Griffin JM, Bradke F. Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem[J]. EMBO Mol Med, 2020, 12(3): e11505. DOI: 10.15252/emmm.201911505.
[19]
Girgis J, Merrett D, Kirkland S, et al. Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery[J]. Brain, 2007, 130(Pt 11): 2993-3003. DOI: 10.1093/brain/awm245.
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