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中华神经创伤外科电子杂志 ›› 2020, Vol. 06 ›› Issue (06) : 373 -376. doi: 10.3877/cma.j.issn.2095-9141.2020.06.011

所属专题: 文献

综述

雌激素作用下神经干细胞移植治疗创伤性脑损伤的研究进展
梁雨婷1, 胡悦1, 赵安琪1, 王沐榕1, 孙建1, 李力卓1,()   
  1. 1. 100053 北京,首都医科大学宣武医院急诊科
  • 收稿日期:2020-06-20 出版日期:2020-12-15
  • 通信作者: 李力卓
  • 基金资助:
    国家自然科学基金(81660329); 首都医科大学本科生科研项目(XSKY2019)

Research progress of neural stem cells with estrogen treating on traumatic brain injury

Yuting Liang1, Yue Hu1, Anqi Zhao1, Murong Wang1, Jian Sun1, Lizhuo Li1,()   

  1. 1. Department of Emergency, Capital Medical University Xuanwu Hospital, Beijing 100053, China
  • Received:2020-06-20 Published:2020-12-15
  • Corresponding author: Lizhuo Li
  • About author:
    Corresponding author: Li Lizhuo, Email:
引用本文:

梁雨婷, 胡悦, 赵安琪, 王沐榕, 孙建, 李力卓. 雌激素作用下神经干细胞移植治疗创伤性脑损伤的研究进展[J]. 中华神经创伤外科电子杂志, 2020, 06(06): 373-376.

Yuting Liang, Yue Hu, Anqi Zhao, Murong Wang, Jian Sun, Lizhuo Li. Research progress of neural stem cells with estrogen treating on traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(06): 373-376.

众所周知,雌激素是神经系统中一种十分重要的信号分子。近几年研究证实,雌激素对神经干细胞(NSCs)的生长发育、增殖分化具有促进作用,并且对其分化方向具有控制作用。NSCs移植治疗创伤性脑损伤(TBI)的实验研究众多,表明了NSCs的水平与TBI的恢复程度和预后密切相关。为了详细阐述最新的研究发现,本文就雌激素对NSCs的控制作用和分化方向的调控作用,以及NSCs移植治疗TBI的临床应用作一综述。

It is well known that estrogen is a very important signal molecule in the nervous system. In recent years, studies have proved that estrogen has a promoting effect on the growth and development, proliferation as well as differentiation of neural stem cells (NSCs), which having a controlling effect on the direction of their differentiation. There have also been numerous experimental studies on the treatment of traumatic brain injury (TBI) by NSCs transplantation, indicating that the level of NSCs is closely related to the recovery degree and prognosis of TBI. In order to elaborate on the latest findings, the authors will review the effects of estrogen on the control and differentiation of NSCs, as well as the clinical application of NSCs transplantation in the treatment of TBI.

[1]
Arnold AP, Breedlove SM. Organizational and activational effects of sex steroids on brain and behavior: a reanalysis[J]. Horm Behav, 1985, 19(4): 469-498.
[2]
Ismail FY, Fatemi A, Johnston M. The quest for neuroprotection for injuries in the developing brain[J]. J Inter Child Neurol Asso, 2017, 17: 79-95.
[3]
Calzolari F, Michel J, Baumgart EV, et al. Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone[J]. Nat Neurosci, 2015, 18(4): 490-492.
[4]
Deroo BJ, Buensuceso AV. Minireview: estrogen receptor-beta: mechanistic insights from recent studies[J]. Mol Endocrinol, 2010, 24(9): 1703-1714.
[5]
周红利,邓其跃,苏炳银,等.雌激素受体β在成年C57小鼠脑内的表达与性别差异[J].解剖学杂志, 2012, 35(4): 423-426, 435.
[6]
Pan Q, Guo K, Xue M, et al. Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling[J]. Neurochem Int, 2020, 135: 104685.
[7]
刘晓东,张夏南,郝宁,等.雌二醇对大鼠海马神经干细胞增殖的影响[J].解剖学报, 2014, 35(5): 627-632.
[8]
Simoncini T, Mannella P, Fornari L, et al. Genomic and non-genomic effects of estrogens on endothelial cells[J]. Steroids, 2004, 69(8-9): 537-542.
[9]
Murashov AK, Pak ES, Hendricks WA, et al. 17β-estradiol enhances neuronal differentiation of mouse embryonic stem cells[J]. FEBS Lett, 2004, 569(1-3): 165-168.
[10]
Murphy GG, Glanzman DL. Enhancement of sensorimotor connections by conditioning-related stimulation in Aplysia depends on postsynaptic Ca2+[J]. Proc Natl Acad Sci, 1996, 93: 9931-9936.
[11]
杨春.突触素的若干研究[J].河南医学研究, 2004, 13(1): 85-89.
[12]
张广侠,陆阳,叶银萍,等.环境雌激素双酚A对海马神经元树突和突触发育的影响[J].中国药理学与毒理学杂志, 2013, 27(S1): 28-29.
[13]
Zhang L, Ma Y, Liu M, et al. The effects of various estrogen doses on the proliferation and differentiation of cultured neural stem cells[J]. Gen Physiol Biophys, 2019, 38(5): 417-425.
[14]
McEwen B. Estrogen actions throughout the brain[J]. Recent Prog Horm Res, 2002, 57: 357-384.
[15]
Salli U, Reddy AP, Salli N, et al. Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons[J]. Exp Neurol, 2004, 188(2): 351-364.
[16]
Gundlah C, Lu NZ, Mirkes SJ, et al. Estrogen receptor beta (ERbeta) mRNA and protein in serotonin neurons of macaques[J]. Brain Res Mol Brain Res, 2001, 91(1-2): 14-22.
[17]
Lu NZ, Bethea CL. Ovarian steroid regulation of 5-HT1A receptor binging and G protein activation in female monkeys[J]. Neuropsychopharmacology, 2002, 27(1): 12-24.
[18]
Kishi Y, Takahashi J, Koyanagi M, et al. Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells[J]. J Neurosci Res, 2005, 79(3): 279-286.
[19]
Estakhr J, Abazari D, Frisby K, et al. Differential control of dopaminergic excitability and locomotion by cholinergic inputs in mouse substantia nigra[J]. Curr Biol, 2017, 27(13): 1900.e4-1914.e4.
[20]
Bedard P, Langelier P, Villeneuve A. Oestrogens and extrapyramidal system[J]. Lancet, 1997, 2(8052-8053): 1367-1368.
[21]
Miller DB, Ali SF, O’Callaghan JP, et al. The impact of gender and estrogen on striatal dopaminergic neurotoxicity[J]. Ann N Y Acad Sci, 1998, 844(1): 153-165.
[22]
Sawada H, Ibi M, Kihara T, et al. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons[J]. FASEB J, 2000, 14(9): 1202-1214.
[23]
Sawada H, Ibi M, Kihara T, et al. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death[J]. J Neurosci Res, 1998, 54(5): 707-719.
[24]
Poser SW, Androutsellis-Theotokis A. Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration[J]. Stem Cell Res Ther, 2014, 5(6): 127.
[25]
Shear DA, Tate CC, Tate MC, et al. Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location[J]. Restor Neurol Neurosci, 2011, 29(4): 215-225.
[26]
Pang AL, Xiong LL, Xia QJ, et al. Neural stem cell transplantation is associated with Iinhibition of apoptosis, Bcl-xL upregulation, and recovery of neurological function in a rat model of traumatic brain injury[J]. Cell Transplant, 2017, 26(7): 1262-1275.
[27]
Spurlock MS, Ahmed AI, Rivera KN, et al. Amelioration of penetrating ballistic-like brain injury induced cognitive deficits after neuronal differentiation of transplanted human neural stem cells[J]. J Neurotrauma, 2017, 34(11): 1981-1995.
[28]
Rabenstein M, Hucklenbroich J, Willuweit A, et al. Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4[J]. Stem Cell Res Ther, 2015, 6(1): 99.
[29]
Addington CP, Dharmawaj S, Heffernan JM, et al. Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1α[J]. Matrix Biol, 2016, 16: 30210-30214.
[30]
Cao T, Thomas TC, Ziebell JM, et al. Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat[J]. Neuroscience, 2012, 225: 65-75.
[31]
Zhang Q, Wu HH, Wang Y, et al. Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer’s disease[J]. J Neurochem, 2016, 136(4): 815-825.
[32]
Su P, Zhang J, Zhao F, et al. The interaction between microglia and neural stem/precursor cells[J]. Brain Res Bull, 2014, 109: 32-38.
[33]
Wang LQ, Lin ZZ, Zhang HX, et al. Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke[J]. CNS Neurosci Ther, 2014, 20(4): 317-326.
[34]
Lee ST, Chu K, Jung KH, et al. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke[J]. Brain, 2008, 131(Pt 3): 616-629.
[35]
Marsh SE, Blurton-Jones M. Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support[J]. Neurochem Int, 2017, 106: 94-100.
[36]
Gölz C, Kirchhoff FP, Westerhorstmann J, et al. Sex hormones modulate pathogenic processes in experimental traumatic brain injury[J]. J Neurochem, 2019, 150(2): 173-187.
[37]
Khaksari M, Abbasloo E, Dehghan F, et al. The brain cytokine levels are modulated by estrogen following traumatic brain injury: which estrogen receptor serves as modulator?[J]. Int Immunopharmacol, 2015, 28(1): 279-287.
[38]
Lord JM, Midwinter MJ, Chen YF, et al. The systemic immune response to trauma: an overview of pathophysiology and treatment[J]. Lancet, 2014, 384(9952): 1455-1465.
[39]
Slowik A, Beyer C. Inflammasomes are neuroprotective targets for sex steroids[J]. J Steroid Biochem Mol Biol, 2015, 153: 135-143.
[40]
Estakhr J, Abazari D, Frisby K, et al. Differential control of dopaminergic excitability and locomotion by cholinergic inputs in mouse substantia nigra[J]. Curr Biol, 2017, 27(13): 1900.e4-1914.e4.
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