评估丙戊酸钠治疗小儿颅脑创伤后继发性癫痫的治疗效果。

选取自吉林大学第一医院从2014年3月至2016年3月收治的70例小儿颅脑创伤后继发性癫痫患儿作为研究对象，并按随机抽签方式分组，治疗组（35例）采用丙戊酸钠治疗，对照组（35例）采用苯妥英钠治疗，比较2组患儿治疗效果以及治疗前后脑电图变化。

（1）治疗组患者的治疗总有效率（94.29%）高于对照组（74.29%），差异有统计学意义（P<0.05）；（2）治疗前，治疗组患者、对照组患者的脑电图正常率、广泛性异常率、局灶性异常率的组间对比差异均无统计学意义（P>0.05）；治疗后，治疗组患者的脑电图正常率（88.57%）高于对照组（57.14%），差异有统计学意义（P<0.05），而脑电图广泛性异常率明显低于对照组，差异有统计学意义（P<0.05）。

丙戊酸钠对于小儿颅脑创伤后继发性癫痫有显著的治疗效果，并且与传统的抗癫痫药物苯妥英钠相比可获得更高的治疗有效率。

Pediatric traumatic brain injury (TBI) is a common disease in neurosurgery department. Some patients would complicate with secondary epilepsy. Frequent epilepsy attack would impact brain function of child who is in the growth and development period, which would result in secondary brain injury. For these reasons, the treatment of complicated secondary epilepsy has great clinical meaning. The aim of the study is to evaluate the effect of sodium valproate on the treatment of pediatric post-traumatic Epilepsy (PTE).

A prospective study was conducted in 70 patients who had undergone pediatric PTE from March 2014 to March 2016 in our hospital. The patients were grouped on the basis of random draw group. Treatment group (n=35) is treated with sodium valproate while control group (n=35) is treated with phenytoin sodium. Comparation is performed in electroencephalogram (EEG) between two groups.

The total effect rate of treatment group (94.29%, P<0.05) is higher than that of control group (74.29%). There is no significant difference in pre-operation EEG normalization rate, widespread abnormal rate, focal abnormal rate between treatment group and control group (P>0.05). Comparably, there is significant difference in post-operation EEG normalization rate (88.57% of treatment group vs 57.14% of control group, P<0.05), widespread abnormal rate between treatment group and control group (P<0.05).

Sodium valproate has significant treatment effect on the treat of epilepsy secondary from pediatric TBI. Moreover, sodium valproate has more treatment effect compared with phenytoin sodium.