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中华神经创伤外科电子杂志 ›› 2016, Vol. 02 ›› Issue (04) : 241 -244. doi: 10.3877/cma.j.issn.2095-9141.2016.04.012

所属专题: 文献

专题笔谈

MicroRNA调控胶质瘤替莫唑胺化疗耐药的研究进展
徐勇明1, 王宏勤1,()   
  1. 1. 030001 太原,山西医科大学第一临床医学院神经外科
  • 收稿日期:2016-03-18 出版日期:2016-08-15
  • 通信作者: 王宏勤
  • 基金资助:
    国家自然科学基金(NO:81470115)

Advances in Glioma Temozolomide-Resistance Regulated by MicroRNA

Yongming Xu1, Hongqin Wang1,()   

  1. 1. Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2016-03-18 Published:2016-08-15
  • Corresponding author: Hongqin Wang
  • About author:
    Corresponding author: Wang Hongqin, Email:
引用本文:

徐勇明, 王宏勤. MicroRNA调控胶质瘤替莫唑胺化疗耐药的研究进展[J]. 中华神经创伤外科电子杂志, 2016, 02(04): 241-244.

Yongming Xu, Hongqin Wang. Advances in Glioma Temozolomide-Resistance Regulated by MicroRNA[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(04): 241-244.

microRNA是一类非编码的内源性小分子RNA,对基因表达进行转录后水平的调控。国内外学者对miRNA在胶质瘤耐药中的作用做了积极的探索和研究,发现miRNA在耐药中起十分重要的作用。本文将阐述miRNA与胶质瘤替莫唑胺化疗耐药基因的关系,促进在胶质瘤中针对特定通路的新靶向治疗的进一步发展。

MicroRNAs(miRNA) are small non-coding RNAs of endogenous small molecules, which are important to regulate the post-transcription of gene expression. MiRNAs in glioma drug resistance has been explored and researched, found that the miRNA plays an important role in drug resistance. Currently, we made a systematic review of the miRNA and Glioma for Temozolomide (TMZ) chemotherapy drug resistance gene for promoting specific pathways in Glioma of new targeted therapy of the further development.

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