To investigate the efficacy of transsphenoidal endoscopic functional pituitary tumor resection, and to analyze the postoperative changes in pituitary hormone levels and their impact on visual function.

A total of 58 patients with functional pituitary tumors who underwent surgical treatment at Neurosurgery Dpartment of Yibin Second People's Hospital from April 2018 to April 2022 were retrospectively analyzed. According to different surgical methods, the control group (n=28) underwent transsphenoidal microscopic pituitary tumor resection, while the study group (n=30) underwent transsphenoidal neuroendoscopic pituitary tumor resection. Pituitary hormone levels, visual function, surgical time, intraoperative blood loss, postoperative hospital stay, recurrence rate, and resection rate were compared between the two groups.

The postoperative levels of human growth hormone (HGH) in patients with HGH tumors, pattern standard deviation of visual field, and mean deviation of visual field in the study group were significantly lower than those in the control group, while the visual field indexwas significantly higher than that in the control group (P<0.05). The study group also demonstrated shorter surgical duration, reduced postoperative hospital stay, and lower tumor recurrence rates compared to the control group, with a higher total tumor resection rate compared to the control group (P<0.05). However, no statistically significant differences were observed between the two groups in postoperative prolactin levels among prolactinoma patients, postoperative adrenocorticotropic hormone levels among adrenocorticotropic hormone patients, or intraoperative blood loss (P>0.05).

Transsphenoidal neuroendoscopic resection is effective for functional pituitary adenomas, offering significant advantages in reducing serum growth hormone levels, improving visual function, and increasing the gross-total resection rate.