Research progress on the mechanism of mitochondria related to secondary brain injury after intracerebral hemorrhage

doi:10.3877/cma.j.issn.2095-9141.2024.02.008

Abstract

Abstract:

Intracerebral hemorrhage is a cerebrovascular disease with high disability rate, high mortality rate and low cure rate. The brain injury caused by intracerebral hemorrhage will cause very serious damage to the patient's brain tissue, one of the main pathological mechanisms is the destruction of the patient's mitochondrial structure and functional homeostasis, the changes of mitochondrial structure and function in patients with secondary brain injury after intracerebral hemorrhage are of great significance for the protection of neurons. In recent years, with the deepening of the research on mitochondrial homeostasis imbalance such as mitochondrial permeability transition pore, mitochondrial autophagy and mitochondrial oxidative stress, the related mechanism between it and secondary brain injury after intracerebral hemorrhage has become more and more clear. This paper summarizes and summarizes the related mechanisms between secondary brain injury and mitochondria after intracerebral hemorrhage, in order to provide new ideas and methods for the clinical application of secondary brain injury after intracerebral hemorrhage.

Key words: Intracerebral hemorrhage, Secondary brain injury, Mitochondrion, Mechanism, Research progress

Nan Miao, Ziyu Zong. Research progress on the mechanism of mitochondria related to secondary brain injury after intracerebral hemorrhage[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2024, 10(02): 107-111.

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