To explore the clinical application value of stereotactic puncture drainage in the treatment of basal ganglia cerebral hemorrhage.

Retrospective analysis was performed on the clinical data of 66 patients with basal ganglia cerebral hemorrhage treated in Craniocerebral Surgery Department of Jingzhou First People's Hospital Affiliated to Yangtze University between June 2019 and June 2020. According to different surgical methods, 33 patients undergoing traditional craniotomy were selected as control group, and another 33 patients treated with stereotactic puncture drainage during the same period were enrolled as drainage group. Perioperative indicators, efficacy, serum aquaporin 4 (AQP4), thrombospondin (TSP) 1 and TSP2 and cerebral edema volume were observed and compared between the two groups.

The surgical time and hospital stay of drainage group were shorter than those of control group, and the intraoperative blood loss was lower than that of control group while the hematoma clearance rate was higher than that of control group (P<0.05). The postoperative efficacy was better in drainage group than that in control group (P<0.05). The levels of serum AQP4, TSP1 and TSP2 of patients in drainage group were lower than those of control group, the volume of cerebral edema in drainage group was lower than that in the control group (P<0.05).

Stereotactic puncture drainage can improve the perioperative indicators, enhance the efficacy, lower the level of serum AQP4 and reduce the volume of cerebral edema of patients with basal ganglia cerebral hemorrhage.