To explore the early clinical treatment strategy of open traumatic brain injury (TBI).

The clinical data of 50 patients with open TBI treated in Neurosurgery Department of the 900^th Hospital of Joint Logistics Team from June 2010 to January 2020 were selected. According to the operation time, they were divided into the early group (<6 h, 25 cases) and the late group (6-12 h, 25 cases). Twelve patients with skull base fracture phaseⅠ were treated with skull base reconstruction. After 72 h, the GOS score, clinical deterioration outcome and postoperative complications were compared between the two groups.

All 12 patients with skull base fracture underwent skull base reconstruction in phase Ⅰ, and there were no complications such as meningoencephalocele and cerebrospinal fluid leakage. The postoperative 72 h GOS score in the early group was higher than in the late group. The incidence of postoperative 72 h death, severe TBI, intracranial infection, stress ulcer, epilepsy and pulmonary infection in the early group was lower than in the late group (P<0.05).

For open TBI, eraly operation and skull base reconstruction in phase Ⅰ can effectively reduce the postoperative complications and improve the prognosis of patiens.