To explore the efficacy of 3D-slicer assisted neuroendoscopy in the treatment of cerebral hemorrhage in basal ganglia at different periods.

A retrospective analysis of 96 patients with hypertensive basal ganglia cerebral hemorrhage admitted to Neurosurgery Department of The Third Hospital of Xingtai from January 2017 to January 2019. According to the operation time, they were divided into ultra-early group (onset time less than 6 h, n=50) and early-stage group (onset time 6-24 h, n=46). Both groups were performed neuroendoscopic surgery assisted by 3D-slicer. The complications, clinical prognosis and changes of neuron-specific enolase (NSE) in cerebrospinal fluid were compared between the two groups.

There was no significant difference in rebleeding and intracranial infection between the ultra-early group and the early-stage group (P>0.05), but the number of pneumonia and lower extremity venous thrombosis in the ultra-early group was less than that in the early-stage group (P<0.05). The patients of mild disability in GOS score of the ultra-early group were more than that of the early-stage group, and the patients of severe disability in GOS score were less than that of the early-stage group, the differences were statistically significant (P<0.05). The content of NSE in cerebrospinal fluid of the ultra-early group was lower than that of early-stage group on the 7^th and 14^th day after operation, the differences were statistically significant (P<0.05).

Ultra-early application of 3D-slicer assisted neuroendoscopy to treat cerebral hemorrhage in the basal ganglia can effectively improve the clinical prognosis of patients, reduce the incidence of related complications after cerebral hemorrhage, and not increase the rebleeding rate.