To compare the clinical efficacy of neuroendoscopy and neuronavigation assisted microscopy in the treatment of pituitary tumors by transnasal transsphenoidal approach.

One hundred and sixty patients with pituitary adenoma admitted to Xiangyang First People’s Hospital Affiliated to Hubei Medical College from January 2016 to July 2018 were selected. The patients were randomly divided into neural endoscopic group (neural endoscopic nasal adjustment approach resection of pituitary adenoma) and neural navigation group (neural navigation AIDS microscope nasal adjustment approach resection of pituitary adenoma), 80 patients in each group. comparing two groups of patients before and after the treatment of growth hormone, prolactin (PRL), growth hormone (GH) and adrenocorticotropic hormone (ACTH) content difference, comparing two groups of patients with operation indicators, clinical curative effect and complications of statistical difference.

The operation time in the neuroendoscopic group was shorter than that in the neuronavigation group, the intraoperative blood loss in the neuroendoscopic group was less than that in the neuronavigation group, and the postoperative hospitalization time in the neuroendoscopic group was shorter than that in the neuronavigation group. After treatment, PRL, GH and ACTH contents in patients in the neuronavigation group were significantly higher than those in the neuroendoscopy group. The effective rate of patients in the neuroendoscopic group (92.50%) was higher than that in the neuronavigation group (81.25%). The incidence of diabetes insipidus, visual impairment and nasal bleeding in the neuronavigation group was significantly higher than that in the neuroendoscopy group (P<0.05) .

Compared with neuronavigation-assisted microscopy for the resection of pituitary tumor through nasal transsphenoidal approach, neuroendoscopy has better clinical efficacy, fewer complications and better recovery of pituitary function.