Correlational studies of prognosis and plasma HMGB1 concentration in different time of cerebral contusion

doi:10.3877/cma.j.issn.2095-9141.2016.06.004

Abstract

Abstract:

Objective

To explore the correlational studies of prognostic and plasma HMGB1 in different time in patients with cerebral contusion.

Methods

Forty cases from the 153rd Hospital of PLA with cerebral contusion from January 2014 to January 2015 are divided into two groups by the prognosis: the well-prognosis group (GOS 4~5) and bad-prognosis group (GOS 1~3); an analysis and comparision between the two groups were performed focusing on plasma HMGB1 concentration between the two groups.

Results

In early time the plasma HMGB1 concentration is (4.87±1.42) ng/ml in well-prognosis group, (6.32±1.23) ng/ml in bad-prognosis group, the concentration of bad-prognosis group was significantly higher than well-prognosis group (t=3.127, P<0.05); in 6th day the plasma HMGB1 concentration is (9.49±1.57) ng/ml in well-prognosis group, (9.83±1.49) ng/ml in bad-prognosis group, the concentration of bad-prognosis group was not significantly higher than well-prognosis group (t=1.846, P>0.05); in 15th day the plasma HMGB1 concentration is (7.76±1.04) ng/ml in well-prognosis group, (8.67±1.51) ng/ml in well-prognosis group, the concentration of bad-prognosis group was significantly higher than well-prognosis group (t=2.246, P<0.05).

Conclusion

Plasma HMGB1 concentration is a good chemiscal mark of the prognostic of unilateral contision.

Key words: Cerebral contusion, Cerebral injury, High mobility group protein B1

Fuqiang Cao, Benhan Wang, Anhui Yao, Jinglun Li, Mingli Wu. Correlational studies of prognosis and plasma HMGB1 concentration in different time of cerebral contusion[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(06): 338-340.

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Figures/Tables 3

References 11

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组别	挫伤与水肿体积大于30 ml	挫伤与水肿体积小于30 ml
恢复不良组	11（57.9%）	8（42.1%）
恢复良好组	6（28.6%）	15（71.4%）
χ²值	5.963
P值	0.017

组别	挫伤与水肿体积大于30 ml	挫伤与水肿体积小于30 ml
恢复不良组	11（57.9%）	8（42.1%）
恢复良好组	6（28.6%）	15（71.4%）
χ²值	5.963
P值	0.017

组别	轻型颅脑损伤	中性颅脑损伤	重型颅脑损伤
恢复不良组	3（15.8%）	6（31.6%）	10（52.6%）
恢复良好组	11（52.4%）	8（38.1%）	2（9.5%）
χ²值	?	7.912	?
P值	?	0.021	?

组别	轻型颅脑损伤	中性颅脑损伤	重型颅脑损伤
恢复不良组	3（15.8%）	6（31.6%）	10（52.6%）
恢复良好组	11（52.4%）	8（38.1%）	2（9.5%）
χ²值	?	7.912	?
P值	?	0.021	?

组别	入院时血浆HMGB1浓度	第6天血浆HMGB1浓度	第15天血浆HMGB1浓度
恢复不良组	6.32±1.23	9.49±1.57	8.67±1.51
恢复良好组	4.87±1.42	9.83±1.49	7.76±1.04
t值	3.127	1.846	2.246
P值	0.003	0.073	0.034

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