To investigate the mechanism and related risk factors for massive infarction in patients with severe traumatic brain injury.

Retrospectively reviewed the clinical data of the 113 paients with severe traumatic brain injury in department of neurosurgery, Shenzhen second people's hospital from January 2012 to June 2014, from which the qualified cases of severe craniocerebral injury were selected, and then divided into PTCI group and non PTCI group according to the head CT examination results whether the occurrence of PTCI. The risk factors were evaluated by univariate and multivariate study, SPSS 19.0 statistical software was applicated for analyzing, univariate analysis by Chi-square examination, multivariate analysis by Logistic regression.

By univariate analysis, the differences of these six risk factors, Low GCS scores, cerebral hernia, hypotension, Preoperative coagulation dysfunction, subarachnoid hemorrhage, the application of hemostatic agents after injury, between the two groups was statistically significant(P<0.05), they were important risk factors for PTCI. By multivariate logistic analysis, Low GCS scores, cerebral hernia, hypotension, the application of hemostatic agents after injury were the independent risk factors for PTCI.

Low GCS scores, cerebral hernia, hypotension, Preoperative coagulation dysfunction, subarachnoid hemorrhage, the application of hemostatic agents after injury are the important risk factors of PTCI, Low GCS scores, cerebral hernia, hypotension, Preoperative coagulation dysfunction,subarachnoid hemorrhage, the application of hemostatic agents after injury are the independent risk factors for PTCI. It has important clinical significance for the prevention and treatment of PTCI to focus on these risk factors assessment and reasonable intervention.