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Chinese Journal of Neurotraumatic Surgery(Electronic Edition) ›› 2016, Vol. 02 ›› Issue (03): 136-139. doi: 10.3877/cma.j.issn.2095-9141.2016.03.003

Special Issue:

• Clinical Research • Previous Articles     Next Articles

Effect of atorvastatin in the treatment of postoperative recurrent chronic subdural hematoma

Chuhua Fu1, Bo Chen1, Ning Wang1, Wangwang Liu1, Zhibin Tan1, Yanwei Dang1, Peihai Fang1, Hongquan Wang1, Jun Wang1, Lijun Liu1,()   

  1. 1. Department of Neurosurgery, The First People’s Hospital of Xiangyang, Xiangyang, Hubei 441000, China
  • Received:2015-07-28 Online:2016-06-15 Published:2016-06-15
  • Contact: Lijun Liu
  • About author:
    Corresponding author: Liu Lijun, Email:

Abstract:

Objective

To investigate the clinical effects of atorvastatin in the treatment of postoperative recurrent chronic subdural hematoma.

Methods

From January 2014 to September 2015, 17 patients in the first people’s hospital of xiangyang were selected as research objects. These patients received oral atorvastatin and the patient’s symptoms, daily life ability ADL score, the degree of absorption of the hematoma were observed to determine the efficacy on admission and 1th, 2th week, 1th, 3th month after the therapy.

Results

On 1th week the symptoms improved in 13 (13/16, 81.25%) cases, ADL score increased in (15/16, 93.75%) cases (P<0.05). On 2th week the hematoma were began to reduce (P<0.05). On 3th month, ADL score returned to normal, the symptoms improved completely, and the intracranial hematoma was completely absorbed in 15 cases. ADL score returned to normal, the symptoms improved significantly, most of the intracranial hematoma was absorbed in one case. One patient complicated with acute cholecystitis and abnormal liver function, his condition deteriorated with an enlarged hematoma during the 2th week of treatment and was cured by skull drilling drainage and postoperative oral atorvastatin again.

Conclusion

Atorvastatin in the treatment of postoperative recurrent chronic subdural hematoma has a significant effect, but caution is needed for patients with abnormal liver function.

Key words: Atorvastatin, Chronic subdural hematoma, Effect

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