Neural network hyperactivity in Alzheimer’s disease

doi:10.3877/cma.j.issn.2095-9141.2015.04.010

Abstract

Abstract:

Alzheimer’s Disease(AD)is a common neurological disease,whose specific pathogenesis is still unclear.There are still no effective treatments to prevent,halt,or reverse Alzheimer’s disease.AD patients have an increase dincidence of epileptic seizures.Hyperexcitability has also been observed in various AD transgenic mice.Such aberrant network activity is closely related to cognitive deficits and the pathogenesis of AD.Recent studies suggest that the aberrant network activity is upstream and contributes causally to synaptic,cognitive,and behavioral dysfunctions in AD transgenic mice.Blocking the network hyperactivity with LEV,an antiepileptic drugs(AEDs),which inhibits voltage-dependent sodium channels,reversed synaptic dysfunction and cognitive deficits in hAPPmice.These studies have been paid great attention,especially the potential application of AEDs,in AD therapy.This Review highlights the relationship between the aberrant network activity and AD in AD research,and raises major unresolved issues,especially the potential application of AEDs,in AD therapy.

Key words: Alzheimer disease, Network hyperactivity, Anticonvulsants

Maoying Zhang, Weiqiang Jia, Quanhong Ma, Ruxiang Xu. Neural network hyperactivity in Alzheimer’s disease[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2015, 01(04): 232-236.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsjcswkdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9141.2015.04.010

https://zhsjcswkdzzz.cma-cmc.com.cn/EN/Y2015/V01/I04/232

References 49

［1］	Selkoe DJ.Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein［J］.Journal of Alzheimer'sdisease,2001,3(1):75-80.
［2］	Amatniek JC,Hauser WA,DelCastillo-Castaneda C,et al.Incidence and predictors of seizures in patients with Alzheimer's disease［J］.Epilepsia,2006,47(5):867-872.
［3］	Palop JJ,Mucke L.Epilepsy and cognitive impairments in Alzheimer disease［J］.Archives of neurology.2009,66(4):435-440.
［4］	Harris JA,Devidze N,Verret L,et al.Transsynaptic progression of amyloid-beta-induced neuronal dysfunction within the entorhinal-hippocampal network［J］.Neuron,2010,68(3):428-441.
［5］	Minkeviciene R,Rheims S,Dobszay MB,et al.Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy［J］.The Journal of Neuroscience,2009,29(11):3453-3462.
［6］	Roberson ED,Halabisky B,Yoo JW,et al.Amyloid-beta/Fyninduced synaptic,network,and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease［J］.The Journal of Neuroscience,2011,31(2):700-711.
［7］	Palop JJ,Chin J,Roberson ED,et al.Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease［J］.Neuron,2007,55(5):697-711.
［8］	Vogt DL,Thomas D,Galvan V,et al.Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain［J］.Neurobiology of aging,2011,32(9):1725-1729.
［9］	Ziyatdinova S,Gurevicius K,Kutchiashvili N,et al.Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels［J］.Epilepsy research,2011,94(1-2):75-85.
［10］	Sanchez PE,Zhu L,Verret L,et al.Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model［J］.Proc Natl Acad Sci USA,2012,109(42):2895-2903.
［11］	Cumbo E,Ligori LD.Levetiracetam,lamotrigine,and phenobarbital in patients withepileptic seizures and Alzheimer’sdisease［J］.Epilepsy Behav,2010,17(4):461-466.
［12］	Huang Y,Mucke L.Alzheimer mechaisms and therapeutic strategies［J］.Cell,2012,148(6):1204-1222.
［13］	Cai H,Wang D,McCarthy H,et al.BACE1 is the major beta-secretase for generation of Abeta peptides by neurons［J］.Nat Neurosci,2001,4(3):233-234.
［14］	Hsieh H,Boehm J,Sato C,et al.AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss［J］.Neuron,2006,52(5):831-843.
［15］	Palop J.J,Chin J,Mucke L.A network dysfunction perspective on neurodegenerative diseases［J］.Nature,2006,443(7113):768-773.
［16］	Verret L,Mann EO,Hang GB,et al.Inhibitory interneuron de ficit links altered networkactivity and cognitive dysfunction in Alzheimer model［J］.Cell,2012,149(3):708-721.
［17］	Meilandt WJ,Yu GQ,Chin J,et al.Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer’s disease［J］.J.Neurosci,28(19):5007-5017.
［18］	Palop JJ,Jones B,Kekonius L,et al.Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits［J］.Proc Natl Acad Sci U SA,2003,100(16):9572-9577.
［19］	Palop JJ,Chin J,Bien Ly N,et al.Vulnerability of dentate granule cells to disruption of Arc expressionin human amyloid precursor protein transgenic mice［J］.J Neurosci,2005,25(42):9686-9693.
［20］	Chin J,Palop JJ,Puoliväli J,et al.Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer'sdisease［J］.JNeurosci,2005,25(42):9694-9703.
［21］	Bero AW,Yan P,Roh JH,et al.Neuronal activity regulates the regional vulnerability to amyloid deposition［J］.Nat Neurosci,2011,14(6):750-756.
［22］	Hong Qing,Guiqiong He,PhilipT.T.Ly,et al.Valproic acid inhibits Aβproduction,neuritic plaque formation,and behavioral deifcits in Alzheimer’s disease mouse models［J］.J.Exp.Med,2008,205(12):2781-2789.
［23］	The Alzheimer disease and frontotemporal dementia mutation database.Flanders Interuniversity Institute for Biotechnology Department of Molecular Genetics Web site;2008.
［24］	Amatniek JC,Hauser WA,Delcastillo-Castaneda C,et al.Incidence and predictors of seizures in patients with Alzheimer’sdisease［J］.Epilepsia,2006,47(5):867-872.
［25］	Larner AJ,Doran M.Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of thepresenilin-1 gene［J］.JNeurol,2006,253(2):139-158.
［26］	Snider BJ,Norton J,Coats MA,et al.Novel presenilin 1 mutation(S170F)causing Alzheimer disease with Lewy bodies in the third decade of life［J］.Arch Neurol,2005,62(12):1821-1830.
［27］	Palop JJ,Mucke L.Amyloid-βInduced Neuronal Dysfunction in Alzheimer’s Disease:From Synapses toward Neural Networks［J］.Nat Neurosci,2010,13(7):812-818.
［28］	Mahley RW,Weisgraber KH,Huang Y.Apolipoprotein E4:a causative factor and therapeutic target in neuropathology,including Alzheimer's disease［J］.Proc Natl Acad Sci U S A,2006,103(15):5644-5651.
［29］	Ponomareva NV,Korovaitseva GI,Rogaev EI.EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease［J］.Neurobiol Aging,2008,29(6):819-827.
［30］	Ponomareva NV,Selesneva ND,Jarikov GA.EEG alterations in subjects at high familial risk for Alzheimer's disease.Neuropsychobiology,2003,48(3):152-159.
［31］	Vossel KA,Beagle AJ,Rabinovici GD,et al.Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease［J］.JAMA Neurol,2013,70(9):1158-1566.
［32］	Koh MT,Haberman RP,Foti S,et al.Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment［J］.Neuropsychopharmacology,2010,35(4):1016-1025.
［33］	Bakker A,Krauss GL,Albert MS,et al.Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitiveimpairment［J］.Neuron,2012,74(3):467-474.
［34］	Cumbo E,Ligori LD.Levetiracetam,lamotrigine,and phenobarbital in patients withepileptic seizures and Alzheimer’sdisease［J］.Epilepsy Behav,2010,17(4):461-466.
［35］	Mendez M,Lim G.Seizures in elderly patients with dementia:epidemiology and management［J］.Drugs Aging,2003,20(11):791-803.
［36］	Fleisher AS,Truran D,Mai JT,et al.Alzheimer’s Disease Cooperative Study.Chronic divalproex sodium use and brain atrophy in Alzheimer disease［J］.Neurology,2011,77(13):1263-1271.
［37］	Tariot PN,Schneider LS,Cummings J,et al.Alzheimer’s Disease Cooperative Study Group.Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease［J］.Arch Gen Psychiatry,2011,68(8):853-861.
［38］	Irizarry MC,Jin S,He F,et al.Incidence of new-onset seizures in mild to moderate Alzheimer disease［J］.Arch Neurol,2012,69(3):368-372.
［39］	Bakker A,Krauss GL,Albert MS,et al.Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitiveimpairment［J］.Neuron,2012,74(3):467-474.
［40］	Meehan AL,Yang X,McAdams BD,et al.A new mechanism for antiepileptic drug action:vesicular entry may mediate the effects of levetiracetam［J］.J Neurophysiol,2011,106(3):1227-1239.
［41］	Shi JQ,Wang BR,Tian YY,et al.Antiepileptics topiramate and levetiracetam alleviate behavioral deficits and reduce neuropathology in APPswe/PS1dE9 transgenic mice［J］.CNS Neurosci Ther,2013,19(11):871-881.
［42］	Cardinale JP,Sriramula S,Pariaut R,et al.HDAC inhibition attenuates inflammatory,hypertrophic,and hypertensive responses in spontaneously hypertensive rats［J］.Hypertension,2010,56(3):437-444.
［43］	Kochanek AR,Fukudome EY,Li Y,et al.Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model［J］.JSurg Res2011,176(1):185-194.
［44］	Kim HJ,Rowe M,Ren M,et al.Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke:Multiple mechanisms of action［J］.JPharmacol Exp Ther,2007,321(3):892-901.
［45］	Suh HS,Choi S,Khattar P,et al.Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes［J］.J Neuroimmune Pharmacol,2010,5(4):521-532.
［46］	Mark RJ,Ashford JW,Goodman Y,et al.Anticonvulsants attenuate amyloid beta-peptide neurotoxicity,Ca2+deregulation,and cytoskeletalpathology［J］.Neurobiol Aging,1995,16(2):187-198.
［47］	Angehagen M,Margineanu DG,Ben-Menachem E,et al.Levetiracetam reduces caffeine-induced Ca2+transients and epileptiform potentials in hippocampal neurons［J］.Neuroreport,2003,14(3):471-475.
［48］	Pisani A,Bonsi P,Martella G,et al.Intracellular calcium increase in epileptiform activity:Modulation by levetiracetam and lamotrigine［J］.Epilepsia,2004,45(7):719-728.
［49］	Chen PS,Wang CC,Bortner CD,et al.Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide induced dopaminergic neurotoxicity［J］.Neuroscience,2007,149(1):203-212.

[1]	Yao Deng, Tao Yu, Xiaolu Chen, Rong Luo. Clinical and follow-up analysis of children with febrile infection-related epilepsy syndrome [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(06): 645-651.
[2]	Junjie Ning, Lina Qiao. Atypical benign familial neonatal epilepsy: a case report and literature review [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(03): 307-314.
[3]	Dongxiao Li, Yupeng Liu, Yuan Ding, Xiyuan Li, Xun Wu, Jinqing Song, Yanling Yang. A patient with initial symptom of epilepsy from age of 12 years old due to early-onset Alzheimer disease caused by presenilin 1 mutation [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(06): 621-626.
[4]	Chunsong Yang, Lingli Zhang, Hong Huang, Cairong Zhu. Research progress on antiepileptic drugs in the treatment of Tourette's syndrome in children [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(03): 407-410.
[5]	Qingshang Deng, Quanhong Ma, Ruxiang Xu. Human beta-secretase and Alzheimer's disease [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2015, 01(04): 237-240.
[6]	Xinna Zhang, Tao Wang, Hongjun Li, Baomin Sun, Xinping Zhang. Humanin and its derivatives with cognitive impairment [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2017, 07(01): 32-35.
[7]	Zhuyu Li, Zilian Wang. Management of epileptic seizures in labor [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2017, 06(01): 28-31.
[8]	Xiaojing Hu, Hongbo Qi. Epilepsy in pregnancy [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2016, 05(02): 102-106.
[9]	Yunchen Xu, Liaoyao Wang, Jian Pei. Correlation between apolipoprotein E gene polymorphism and Alzheimer′s disease syndrome type in traditional Chinese medicine [J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2020, 09(04): 142-145.
[10]	Lin Liu, Wenhuan Zhang, Yaru Song, Yunlu Jiang. Research advances of the neuroprotective mechanism of apelin-13 in Alzheimer disease [J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(04): 276-280.
[11]	Qian Liu, Xin Li, Xin Liu, Jinxiang Yuan. Research progress of ferroptosis in the pathogenesis of Alzheimer′s disease [J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(03): 211-215.
[12]	Mengyang Zhang, Yue Wang. Research situation on the role of glycogen synthase kinase-3β in the pathogenesis and treatment of Alzheimer′s disease [J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 98-102.
[13]	Lei Qiao, Yinyi Sun, Zhongsen Qu. Research situation of tau proteins and β-amyloid protein in the pathological process and autophagic mechanisms in Alzheimer′s disease [J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 94-97.
[14]	Yuzhen Xu, Qian Wang, Min Shan, Tao Wang, Weixia Yang, Xinping Zhang. Effect of hyperbaric oxygen therapy on cognitive function and serum Humanin level in patients with Alzheimer′s disease [J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 83-86.
[15]	Hao He, Qing Guan, Haobo Zhang, Yuejia Luo. Summary of the latest practice guideline on mild cognitive impairment [J]. Chinese Journal of Diagnostics(Electronic Edition), 2018, 06(03): 145-150.

Please choose a citation manager

Content to export